High levels of multiple antibiotic resistance among 938  Haemophilus influenzae type b meningitis isolates from Cuba(1990-2002)

Tamargo, Isis; Fuentes, Kiomy; Llop, Alina; Oteo, Jesús; Campos, José

doi:10.1093/jac/dkg395

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…In the present study the reduction in penicillin resistance was particularly significant among children (Fig. 4), suggesting that vaccination may play a key role in preventing antimicrobial resistance in S. pneumoniae (32), as has been the case for Haemophilus influenzae type b (28).…”

Section: Discussionsupporting

confidence: 62%

Trends in Antimicrobial Resistance in 1,968 Invasive Streptococcus pneumoniae Strains Isolated in Spanish Hospitals (2001 to 2003): Decreasing Penicillin Resistance in Children's Isolates

et al. 2004

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Section: Discussionsupporting

confidence: 62%

Trends in Antimicrobial Resistance in 1,968 Invasive Streptococcus pneumoniae Strains Isolated in Spanish Hospitals (2001 to 2003): Decreasing Penicillin Resistance in Children's Isolates

et al. 2004

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“…Our results are in agreement with findings from a previous study conducted in Dakar (10) and in other countries such as Italia (2), Northen Taiwan (14), Cuba (13), and South Africa (5). This suggests that beta-lactamase production could be the major mechanism of antibiotic resistance for these organisms.…”

Section: Discussionsupporting

confidence: 93%

Antibiotic resistance of bacteria responsible of acute respiratory tract infections in children

et al. 2017

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SummaryBackground and aims. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the most common causative agents of acute respiratory tract infections (RTIs). The objective of this study was to assess their susceptibility to several antibiotics.Materials and methods. A total of 58 strains (16 S. pneumoniae, 19 H. influenzae and 23 M. catarrhalis) were isolated from samples collected in two paediatric centres, and their susceptibility to commonly used antibiotics tested by E-test.Results. Among H. influenzae isolates, 10.5% were resistant to ampicillin (all β-lactamase-positive), and 88.9% were susceptible to cefaclor. High β-lactam resistance rates (penicillin: 31.3% and cephalosporins: 18.7 to 31.3%) had been observed among S. pneumonia strains. Only 50% of isolates were susceptible to azithromycine. 91.3% of M. catarrhalis isolates β-lactamases producers were resistant to ampicillin while susceptible to the most tested antibiotics.Conclusions. Except M. catarrhalis β-lactamases producing strains, frequency of antibiotic resistance was mainly observed among S. pneumoniae, and to a lesser extent among H. influenzae clinical isolates, suggesting the need for continuous surveillance of antimicrobial resistance patterns in the management of RTIs.

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“…The observation that antibiotic resistance is more prevalent in encapsulated isolates, responsible for the majority of meningitis cases, than in nontypeable H. influenzae was also revealed by other authors (4,10,32). The results of some studies showed that there is also an increasing number of H. influenzae isolates resistant to chloramphenicol (e.g., Bangladesh, 21.5%; Paraguay, 20%; Cuba, 44%) and an increasing number of isolates resistant simultaneously to both mentioned antibiotics (2,26,31). Although in our study nonsusceptibility to chloramphenicol was present in less than 2% of the isolates, all of them were simultaneously resistant to ampicillin.…”

Section: Discussionmentioning

confidence: 68%

“…Although we did not find any meningitis BLNAR isolates, the prevalence of such isolates, although rare until recently, is increasing among those responsible for lower respiratory tract infections in Poland, as well as in some other European countries (8). Many countries, such as the United States before the vaccination era and presently Cuba, Bangladesh, and Paraguay, reported a high percentage of ␤-lactamase-producing isolates: 32%, 46.5%, 32.5%, and 30%, respectively (2,26,31,34). In the light of the above data, the percentage of ␤-lactamase producers among Polish meningitis isolates is not very high, although it is three times higher than found among H. influenzae isolates responsible for lower respiratory tract infections in Poland (28).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Haemophilus influenzae Type b Responsible for Meningitis in Poland from 1997 to 2004

et al. 2005

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Two hundred forty-five H. influenzae isolates responsible for meningitis in Poland from 1997 to 2004 were studied. Among these, 233 (95.1%) belonged to serotype b (Hib), 2 belonged to serotype f, and 10 were noncapsulated. The relatedness of all isolates was evaluated by pulsed-field gel electrophoresis (PFGE), and selected representatives were evaluated by multilocus sequence typing. Resistance to ampicillin was identified in 34 (14.6%) of the Hib isolates and was associated with the production of ␤-lactamase only. Except for four isolates nonsusceptible to chloramphenicol, all isolates were susceptible to cefotaxime, ciprofloxacin, and rifampin. The PFGE analysis divided the Hib isolates into five PFGE types; however, all of them were possibly related. The most common PFGE type, with 25 subtypes, was characteristic for 97.4% of the isolates. The most prevalent PFGE subtype found in our study was also the most common among the Hib isolates responsible for invasive disease in Italy and the Czech Republic and was found among isolates causing lower respiratory tract infections in Poland. The most prevalent sequence types (STs) in the studied group were ST6 and ST92. Four new STs were found: ST188, ST189, ST190, and ST268. Results of this study support the evidence that the genetic structure of encapsulated H. influenzae is clonal. The continuing high number of meningitis cases due to Hib in Poland underlines the need for mass vaccination against Hib in Poland.

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High levels of multiple antibiotic resistance among 938 Haemophilus influenzae type b meningitis isolates from Cuba(1990-2002)

Abstract: In Cuba, the widespread vaccination against Haemophilus influenzae type b prevented a large number of meningitis cases in children caused by strains resistant to multiple antibiotics.

Cited by 9 publications

References 8 publications

Trends in Antimicrobial Resistance in 1,968 Invasive Streptococcus pneumoniae Strains Isolated in Spanish Hospitals (2001 to 2003): Decreasing Penicillin Resistance in Children's Isolates

Trends in Antimicrobial Resistance in 1,968 Invasive Streptococcus pneumoniae Strains Isolated in Spanish Hospitals (2001 to 2003): Decreasing Penicillin Resistance in Children's Isolates

Antibiotic resistance of bacteria responsible of acute respiratory tract infections in children

Characteristics of Haemophilus influenzae Type b Responsible for Meningitis in Poland from 1997 to 2004

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