High levels of inosine monophosphate in the erythrocytes of elasmobranchs

Coates, Michael; Paton, Barbara C.; Thompson, Judith

doi:10.1002/jez.1402030217

Cited by 11 publications

References 5 publications

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Isolation of O‐phosphorylethanolamine from the erythrocytes of an elasmobranch (the Southern Fiddler Ray — Trygonorhina fasciata guanerius)

Coates¹,

Thompson²,

Tate³

1979

J. Exp. Zool.

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An amphoteric organic phosphate, which represents 20% of erythrocyte acid soluble phosphate components from an elasmobranch (the Southern Fiddler Ray — Trygonorhina fasciata guanerius) has been isolated as a colourless crystalline solid. Its phosphorus content, melting point behaviour, chromatographic, electrophoretic and ion‐exchange properties, together with its infrared and electron impact mass spectra are consistent with its formulation as O‐phosphorylethanolamine. Assuming minimal degradation in the isolation procedure, the calculated erythrocyte intracellular concentrations of characterised phosphates from the Southern Fiddler Ray are as follows: O‐phosphorylethanolamine (1.89 mM), adenosine triphosphate (1.61 mM), inorganic phosphate (0.26 mM), inosine monophosphate (0.47 mM), guanosine triphosphate (0.34 mM) and adenosine diphosphate (0.11 mM). On a molar basis O‐phosphorylethanolamine is the major acid soluble phosphate of the Southern Fiddler Ray erythrocyte, but examination of the literature suggests its concentration may vary considerably among other elasmobranchs and possible reasons for such variance are considered.

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Isolation of O‐phosphorylethanolamine from the erythrocytes of an elasmobranch (the Southern Fiddler Ray — Trygonorhina fasciata guanerius)

Coates¹,

Thompson²,

Tate³

1979

J. Exp. Zool.

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Cardiovascular and Respiratory Systems

Butler

Metcalfe²

1988

Physiology of Elasmobranch Fishes

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Haemoglobin function and respiratory status of the Port Jackson shark, Heterodontus portusjacksoni , in response to lowered salinity

Cooper

Morris

2004

Journal of Comparative Physiology B: Biochemical, Systemic, and

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Haemoglobin function and respiratory status of sub-adult sharks, Heterodontus portusjacksoni was investigated for up to 1 week following transfer from 100% to either 75% or 50% seawater. Metabolic rates were unusually low and arterial-venous differences in blood O2 small. Haemodilution from osmotic inflow lowered haematocrit and reduced blood O2 content by up to 50%. There was no change in O2 consumption rate, blood O2 partial pressure, cardiac output, or the arterial-venous O2 content difference, and thus O2 delivery was maintained. Ventilation was acutely elevated but returned to normal within 24 h. The O2 delivery to the tissues was facilitated by decreased blood O2-affinity that could not be simply ascribed to changes in the osmolyte concentration. The Hb was unaffected by changes in intra-erythrocyte fluid urea or trimethylamine-N-oxide (TMAO) but was sensitive to changes in NaCl. The Bohr shifts in whole blood were low and there was little role for pH in modulating O2 transport. Venous Hb saturation remained close to 65%, at the steepest part of the in vivo O2 equilibrium curve, such that O2 unloading could be facilitated by small reductions in pressure without increasing cardiac or ventilatory work. H. portusjacksoni tolerated 50% seawater for at least 1 month, but there was little evidence of respiratory responses being adaptive which instead appeared to be consequential on changes in osmotic and ionic status.

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High levels of inosine monophosphate in the erythrocytes of elasmobranchs

Cited by 11 publications

References 5 publications

Isolation of O‐phosphorylethanolamine from the erythrocytes of an elasmobranch (the Southern Fiddler Ray — Trygonorhina fasciata guanerius)

Isolation of O‐phosphorylethanolamine from the erythrocytes of an elasmobranch (the Southern Fiddler Ray — Trygonorhina fasciata guanerius)

Cardiovascular and Respiratory Systems

Haemoglobin function and respiratory status of the Port Jackson shark, Heterodontus portusjacksoni , in response to lowered salinity

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