High levels of glucose at time of diagnosing venous thrombosis: a case‐control study

Tichelaar, Ynse Ieuwe Gerardus Vladimir; Lijfering, Willem M.; Maaten, ter Jan; Kluin-Nelemans, Hanneke C.; Meijer, Karina

doi:10.1111/j.1538-7836.2011.04226.x

Cited by 8 publications

(13 citation statements)

References 9 publications

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“…Consistent with our study, a previous study indicated that smoking, obesity, and hypertension promoted the occurrence of DVT . Recent studies have shown that high glucose level is involved in the activation of coagulation system in healthy men and excess body weight is a significant risk factor for VTE . FVII triggers coagulation and hemostasis in the extrinsic coagulation pathway and initiates key pathogenetic mechanisms in cell proliferation and invasion through interacting with tissue factor, an essential cofactor of FVII activity .…”

Section: Discussionsupporting

confidence: 92%

“…19 Recent studies have shown that high glucose level is involved in the activation of coagulation system in healthy men and excess body weight is a significant risk factor for VTE. 20,21 FVII triggers coagulation and hemostasis in the extrinsic coagulation pathway and initiates key pathogenetic mechanisms in cell proliferation and invasion through interacting with tissue factor, an essential cofactor of FVII activity. 22 Some studies suggested that fibrinogen plays an important role in thrombotic process and that fibrinogen, and FVII play an essential role in hemostasis and their plasma levels are related to the risk of arterial and venous thrombosis.…”

Section: Discussionmentioning

confidence: 99%

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Genetic polymorphisms in the FVII gene is associated with lower extremity deep venous thrombosis: A case‐control study

Liu¹,

Chen

2018

J of Cellular Biochemistry

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This study aims to explore the associations between FVII gene polymorphisms (R353Q, 5'F7, and -402G/A) and lower extremity deep venous thrombosis (LEDVT) in a Chinese Han population. LEDVT patients (153) and healthy people (174) were, respectively, as case and control groups and evaluated related biochemical indicators. Gene polymorphisms of R353Q, 5'F7, and -402G/A of FVII, serum FVII level, antithrombin activity, plasma fibrinogen content, and plasma D-dimer (D-D) level were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), ELISA, chromogenic substrate assay, coagulating assay, and Immunoturbidimetry assay, respectively. Compared with the control group, the case group had a higher level of body mass index (BMI), glucose, and fibrinogen, and lower level of total cholesterol (TC). Notable differences were found in GG genotype, G and A alleles, as well as distribution of recessive model of -402G/A. The serum FVII level of GG genotype was higher than that of GA and AA genotypes. FIB and D-D had a higher level had a lower level in GG genotype when compared with GA and AA genotypes. Smoking, drinking, serum FVII level, and -402G/A-GG were the independent risk factors for LEDVT. This study demonstrates that -402G/A of FVII may be a risk factor for LEDVT patients in a Chinese Han population.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms in the FVII gene is associated with lower extremity deep venous thrombosis: A case‐control study

Liu¹,

Chen

2018

J of Cellular Biochemistry

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“…Our findings contribute to ongoing discussions about whether stress hyperglycemia solely results from the physical stress induced by the venous thrombo-embolic event itself or whether it may reflect a pre-existent disturbed glucose homeostasis [4,8]. Although disturbed glucose homeostasis will be present in a proportion of patients with PE, the present findings suggest that overall, PE patients do not carry an elevated risk of developing DM.…”

supporting

confidence: 58%

“…, is estimated at nearly 100%; its reported specificity, however, varies between 30% and 40% [7,8]. Standardized clinical decision rules (CDRs) are therefore additionally used in suspected PE.…”

Section: Disclosure Of Conflict Of Interestsmentioning

confidence: 99%

The incidence of diabetes mellitus following pulmonary embolism: a retrospective cohort study

Sechterberger

Hutten

Hermanides

et al. 2012

Journal of Thrombosis and Haemostasis

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“…In contrast to our findings, a case–control study suggested that hyperglycemia was related to an increased risk of VTE, independently of known diabetes. However, in this study, non‐fasting glucose levels were measured on admission for a suspected DVT , and the elevated glucose levels in VTE patients could potentially be attributable to the inflammatory and counter‐regulatory hormone action initiated by the VTE event itself .…”

Section: Discussionmentioning

confidence: 95%

Hyperglycemia, assessed according to HbA1c, and future risk of venous thromboembolism: the Tromsø study

Lerstad

Brodin

Enga

et al. 2014

Journal of Thrombosis and Haemostasis

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NorwayTo cite this article: Lerstad G, Brodin EE, Enga KF, Jorde R, Schirmer H, Njølstad I, Svartberg J, Braekkan SK, Hansen J-B. Hyperglycemia, assessed according to HbA 1c , and future risk of venous thromboembolism: the Tromsø study. J Thromb Haemost 2014; 12: 313-9.Summary. Background: HbA 1c , a marker of average plasma glucose level during the previous 8-12 weeks, is associated with the future risk of cardiovascular disease and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed according to HbA 1c , and the future risk of venous thromboembolism (VTE) in a population-based cohort. Methods: HbA 1c was measured in 16 156 unique subjects (25-87 years) who participated in one or more surveys of the Tromsø study (Tromsø 4, 1994(Tromsø 4, -1995 Tromsø 5, 2001 Tromsø 5, -2002 and Tromsø 6, 2007-2008). All subjects were followed, and incident VTE events were recorded up to 31 December 2010. Results: There were 333 validated first VTE events, of which 137 were unprovoked, during a median followup of 7.1 years. HbA 1c was not associated with the future risk of VTE in analyses treating HbA 1c as a continuous variable, or in categorized analyses. The risk of VTE increased by 5% per one standard deviation (0.7%) increase in HbA 1c (multivariable-adjusted hazard ratio [HR] 1.05; 95% confidence interval [CI] 0.97-1.14), and subjects with HbA 1c ≥ 6.5% had a 27% higher risk than those with HbA 1c < 5.7% (multivariable-adjusted HR 1.27; 95% CI 0.72-2.26). There was no significant linear trend for an increased risk of VTE across categories of HbA 1c (P = 0.27). Conclusions: Serum levels of HbA1c were not associated with the future risk of VTE in multivariable analysis. Our findings suggest that hyperglycemia does not play an important role in the pathogenesis of VTE.

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High levels of glucose at time of diagnosing venous thrombosis: a case‐control study

Cited by 8 publications

References 9 publications

Genetic polymorphisms in the FVII gene is associated with lower extremity deep venous thrombosis: A case‐control study

Genetic polymorphisms in the FVII gene is associated with lower extremity deep venous thrombosis: A case‐control study

The incidence of diabetes mellitus following pulmonary embolism: a retrospective cohort study

Hyperglycemia, assessed according to HbA1c, and future risk of venous thromboembolism: the Tromsø study

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