1995
DOI: 10.1172/jci117733
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High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes.

Abstract: The regenerating liver after partial hepatectomy is one of the few physiologic models of cellular proliferation in the adult animal. During hepatic regeneration, the animal is able to maintain metabolic homeostasis despite the acute loss of two thirds of hepatic tissue. In examining the molecular mechanisms regulating hepatic regeneration, we isolated novel immediate-early genes that are rapidly induced as the remnant liver undergoes the transition from its normal quiescent state into the G1 phase of the cell … Show more

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Cited by 137 publications
(121 citation statements)
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“…On the other hand, increased hepatic G6Pase-a activity has been found in human diabetes 33 and in experimental rodent diabetic models. 34,35 Thus, constitutively high-level hepatic G6Pase-a expression may lead to the development of diabetes, and warrants further investigation.…”
Section: Raav1-mediated Gene Therapy For Gsd-iamentioning
confidence: 99%
“…On the other hand, increased hepatic G6Pase-a activity has been found in human diabetes 33 and in experimental rodent diabetic models. 34,35 Thus, constitutively high-level hepatic G6Pase-a expression may lead to the development of diabetes, and warrants further investigation.…”
Section: Raav1-mediated Gene Therapy For Gsd-iamentioning
confidence: 99%
“…However, from animal studies it is clear that hepatic glucose-6-phosphatase is regulated. Hepatic glucose-6-phosphatase enzyme activity [1,8], protein levels [8], and mRNA levels [9] all increase greatly in animal models of diabetes mellitus. Administration of glucocorticoids, insulin, thyroid hormone or glucagon to animals has been shown to alter glucose-6-phosphatase activity in microsomes [1,[10][11][12][13].…”
Section: Introductionmentioning
confidence: 99%
“…Administration of glucocorticoids, insulin, thyroid hormone or glucagon to animals has been shown to alter glucose-6-phosphatase activity in microsomes [1,[10][11][12][13]. In addition, liver glucose-6-phosphatase enzyme activity, protein and mRNA levels are developmentally regulated in mammals [9,14,15]. It therefore seems likely that a number of cis-acting elements will be present in the promoter regulatory region of the glucose-6-phosphatase gene to confer these multiple modes of regulation but to date the 5' region of the gene has not been characterised and very little is known about the mechanisms of hormonal regulation of glucose-6-phosphatase gene expression [16].…”
Section: Introductionmentioning
confidence: 99%
“…Triton X-1002, CHAPS, Serva Blue R-250 and Western-light chemiluminescence detection kit and all other materials for electrophoresis were from Serva (Heidelberg, Germany). Antibodies raised against glucose-6-phosphatase were kindly provided by Dr. Rebecca Taub (University of Pennsylvania, Philadelphia, PA, U.S.A.) [25]. Polyclonal anti-(glucose-6-phosphate translocase) antibodies were generated in rabbit by Eurogentec (Lie!…”
Section: Experimental Materialsmentioning
confidence: 99%