High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222

Brognara, Eleonora; Fabbri, Enrica; Montagner, Giulia; Gasparello, Jessica; Manicardi, Alex; Corradini, Roberto; Bianchi, Nicoletta; Finotti, Alessia; Breveglieri, Giulia; Borgatti, Monica; Milani, Roberta; Dechecchi, Maria Cristina; Cabrini, Giulio; Gambari, Roberto

doi:10.3892/ijo.2015.3308

Cited by 60 publications

(55 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antisense technology also has proven successful in blocking miRNA activity: synthetic oligonucleotides of different chemistries targeted to known oncogenic miRNAs, such as miR-17, miR-21, miR-155, and miR-221/222 promoted not only induction of apoptosis and inhibition of proliferation, but also tumour regression and metastasis suppression in vivo [32][33][34][35][36][37][38]. The drugs Miravirsen and Regulus RG-101, aimed at suppressing miRNA-122 for the treatment of hepatitis C, have successfully progressed into clinical trials, and thus provide grounds to believe that, in the near future, effective antisense-based anti-miRNA therapies will be developed to combat oncopathology [39,40].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

et al. 2017

View full text Add to dashboard Cite

Please cite this article as: Patutina OA, Bichenkova EV, Miroshnichenko SK, Mironova NL, Trivoluzzi LT, Burusco KK, Bryce RA, Vlassov VV, Zenkova MA, miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells, Biomaterials (2017Biomaterials ( ), doi: 10.1016Biomaterials ( / j.biomaterials.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…; Brognara et al. ). In addition, there is also information suggesting a physiological role of these miRNAs in various aspects of skeletogenesis and bone differentiation targeting RUNX2, which is a master transcription factor of osteogenesis (Zhang et al.…”

Section: Resultsmentioning

confidence: 96%

“…miR-222a, miR-205a and miR-205b were expressed at high levels in 6 id interdigits, but their expression was significantly lower at 7.5 id. As for most miRNAs identified in this study, the functional significance of these miRNAs has been associated with oncogenesis, but their function involves inhibition of apoptosis (Zhang et al 2015;Brognara et al 2016). In addition, there is also information suggesting a physiological role of these miRNAs in various aspects of skeletogenesis and bone differentiation targeting RUNX2, which is a master transcription factor of osteogenesis (Zhang et al 2012;Yan et al 2016).…”

Section: Highly Expressed Interdigital Mirnasmentioning

confidence: 90%

Interdigital tissue remodelling in the embryonic limb involves dynamic regulation of the miRNA profiles

et al. 2017

View full text Add to dashboard Cite

Next-generation sequencing in combination with quantitative polymerase chain reaction analysis revealed a dynamic miRNA signature in the interdigital mesoderm of the chick embryonic hinlimb in the course of interdigit remodelling. During this period, 612 previously known chicken miRNAs (gga-miRNAs) and 401 non-identified sequences were expressed in the interdigital mesoderm. Thirty-six microRNAs, represented by more than 750 reads per million, displayed differential expression between stages HH29 (6 id) and HH32 (7.5 id), which correspond to the onset and the peak of interdigital cell death. Twenty miRNAs were upregulated by at least 1.5-fold, and sixteen were downregulated by at least 0.5-fold. Upregulated miRNAs included miRNAs with recognized proapoptotic functions in other systems (miR-181 family, miR-451 and miR-148a), miRNAs associated with inflammation and cell senescence (miR-21 and miR-146) and miRNAs able to induce changes in the extracellular matrix (miR-30c). In contrast, miRNAs with known antiapoptotic effects in other systems, such as miR-222 and miR-205, became downregulated. In addition, miR-92, an important positive regulator of cell proliferation, was also downregulated. Together, these findings indicate a role for miRNAs in the control of tissue regression and cell death in a characteristic morphogenetic embryonic process based on massive apoptosis.

show abstract

“…There is also evidence to the contrary. Peptide nucleic acids (PNAs) targeting either or both miRNA-221 or -222, resulting in a decrease of their levels, were found to be cytotoxic to three glioma cell lines [91]. The temozolomide-resistant cell line, T98G, was re-sensitised to this treatment in the presence of either or both of these PNAs.…”

Section: Mirna-221 and -222 Influence Treatment Sensitivity In Glioblmentioning

confidence: 99%

MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients

Withers

Dewhurst

Hammond

et al. 2020

ncRNA

View full text Add to dashboard Cite

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel class of adipokine, due to their capacity to regulate gene expression in tissues other than fat. Circulating levels of adipokines are known to be altered in obese individuals compared with typical weight individuals and are linked to poorer health outcomes. For example, obese individuals are known to be more prone to the development of some cancers, and less likely to achieve event-free survival following chemotherapy. The purpose of this review was twofold; first to identify circulating miRNAs which are reproducibly altered in obesity, and secondly to identify mechanisms by which these obesity-linked miRNAs might influence the sensitivity of tumors to treatment. We identified 8 candidate circulating miRNAs with altered levels in obese individuals (6 increased, 2 decreased). A second literature review was then performed to investigate if these candidates might have a role in mediating resistance to cancer treatment. All of the circulating miRNAs identified were capable of mediating responses to cancer treatment at the cellular level, and so this review provides novel insights which can be used by future studies which aim to improve obese patient outcomes.

show abstract

High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222

Cited by 60 publications

References 48 publications

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

Interdigital tissue remodelling in the embryonic limb involves dynamic regulation of the miRNA profiles

MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients

Contact Info

Product

Resources

About