High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis

Aubart, F. Cohen; Crestani, Bruno; Nicaise-Roland, Pascale; Tubach, Florence; Bollet, Caroline; Dawidowicz, Karen; Quintin, Emilie; Hayem, Gilles; Palazzo, Élisabeth; Meyer, Olivier; Chollet‐Martin, Sylvie; Dieudé, Philippe

doi:10.3899/jrheum.101261

Cited by 103 publications

(76 citation statements)

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“…These antibodies may be present in the serum for several years before clinical disease onset [15,16]. Both rheumatoid factor and anti-CCP have been linked to the development of ILD, particularly when present in high titres [4,[17][18][19][20][21]. Anti-CCP antibodies have also been associated with the development of airway disease [2].…”

Section: Pathogenesismentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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Section: Pathogenesismentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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“…Recently, Aubart and colleagues reported that high anti-CCP2 levels were independent risk factors for and associated with lung diseases in patients with RA 1 . However, other authors reported no association between anti-CCP and rheumatic lung disease 2,3 .…”

Section: To the Editormentioning

confidence: 99%

Level of Anticitrullinated Peptide/Protein Antibody Is Not Associated with Lung Diseases in Rheumatoid Arthritis

Jearn¹,

Kim²

2012

J Rheumatol

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“…Numerous studies have found that BR precedes RA often by 20-30 years 1,8,13,14 , supporting the hypothesis that BR may be involved in the pathogenesis of RA 1,8,13,14 8,13,18,19 . Initially no link between anti-CCP and lung disease was found 20 , but two studies have reported an association between anti-CCP and airways disease 21 and interstitial lung disease 22 in patients with established RA.…”

Section: Introductionmentioning

confidence: 99%

Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co‐existent bronchiectasis

et al. 2015

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AimPatients with rheumatoid arthritis (RA) and co‐existent bronchiectasis (BRRA) have a five‐fold increased mortality compared to rheumatoid arthritis alone. Yet previous studies have found no difference in clinical and serological markers of RA disease severity between BRRA patients and RA alone. However, RA disease activity measures such as Disease Activity Score of 28 joints – C‐reactive protein (DAS28‐CRP) and anti‐cyclic citrullinated peptide antibodies (anti‐CCP) have not been studied, so we assessed these parameters in patients with BRRA and RA alone.MethodsBRRA patients (n = 53) had high‐resolution computed tomography proven bronchiectasis without any interstitial lung disease and ≥ 2 respiratory infections/year. RA alone patients (n = 50) had no clinical or radiological evidence of lung disease. DAS28‐CRP, rheumatoid factor (immunoglobulin M) and anti‐CCP were measured in all patients, together with detailed clinical and radiology records.ResultsIn BRRA, bronchiectasis predated RA in 58% of patients. BRRA patients had higher DAS28 scores (3.51 vs. 2.59), higher levels of anti‐CCP (89% vs. 46%) and rheumatoid factor (79% vs. 52%) (P = 0.003) compared to RA alone. Where hand and foot radiology findings were recorded, 29/37 BRRA (78%) and 13/30 (43%) RA alone had evidence of erosive change (P = 0.003). There were no significant differences between groups in smoking history or disease‐modifying anti‐rheumatic drug/biologic therapy.ConclusionsIncreased levels of RA disease activity, severity and RA autoantibodies are demonstrated in patients with RA and co‐existent bronchiectasis compared to patients with RA alone, despite lower tobacco exposure. This study demonstrates that BRRA is a more severe systemic disease than RA alone.

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High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis

Abstract: High anti-CCP2 levels are associated with lung disease in the RA population.

Cited by 103 publications

References 15 publications

Rheumatoid arthritis-associated lung disease

Rheumatoid arthritis-associated lung disease

Level of Anticitrullinated Peptide/Protein Antibody Is Not Associated with Lung Diseases in Rheumatoid Arthritis

Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co‐existent bronchiectasis

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