M ultiple Sclerosis (MS) is a chronic, progressive, demyelinating disorder of the Central Nervous System (CNS), seen mostly in young adolescents and early adulthood and it may result in physical disability. [1] Neuropsychiatric symptoms such as depression, fatigue, anxiety, cognitive impairment and alterations in personality can be seen in MS patients. They are usually seen concomitantly, and it is important to discriminate these symptoms in order to give the appropriate treatment. [1,2] Depression is the most prominent symptom seen in these patients and the prevalence was found to be %30.5 in a recent meta analyses. [2] There are many studies investigating the role of alexithymia in depression. [3] Although there are several studies reporting a close relationship between alexithymia and depression , there is no clear opinion whether these two are distinctive from one another or overlapping. [3] Alexithymia means 'Greek a(α-)= absence, inadequacy; lexis(λεξιζ)=-word; thymos (θυμοζ)=feeling'. Sifneos was the first to define alexithymia in patients with psychosomatic disorders. He defined that these patients as patients having difficulty in defining, discriminating and putting their feelings and thoughts in words; had limited fantasy worlds and mostly focused on outer world realities than their own feelings during the therapy. Alexithymia prevalence in multiple sclerosis is not clear since it is mostly seen together with other psychological conditions. [4] The aim of this study is to investigate the relationship between depression and alexithymia in MS. Objectives: A number of psychiatric disorders emerge during the disease course in Multiple Sclerosis (MS). Depression being the most reported disorder; up to date studies showed no clear relationship between alexithymia and depression in these patients. The aim of this study is to investigate the relationship between alexithymia and depression in MS. Methods: 40 patients between ages 18 and 55 admitted to the Neurology Clinic in Okmeydani Training and Research Hospital who were diagnosed with Relapsing Remitting Multiple Sclerosis (RRMS) according to 2010 Mc Donald's criteria and 40 healthy volunteers participated in this study. All subjects had given written consent. Depression and alexithymia status were assessed with Beck Depression Scale (BDS) and Toronto Alexithymia Scale (TAS) respectively. Results: BDS and TAS scores were found significantly higher in MS group especially in women compared to men (p<0.05). It was also observed that alexithymia levels showed increase with high EDSS scores and longer disease period (p<0.05). Conclusion: In this study, it was observed that depression and alexithymia were related with MS.