High Levels of 25-OH-Vitamin D and Copper in Pregnant Women with Abnormal Glucose Challenge Test

Chiang, Chien-Hua; Kung, Wan‐Ju; Lee, Chien-Hung; Zen, Yeong-Hwa; Lee, Cheng-Fa; Yang, Hui-Ru; Lin, Ching‐Chiang; Huang, Yeou‐Lih

doi:10.1007/s12011-021-02920-x

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…A study from Taiwan has even shown opposite results with the higher levels of 25(OH)D in women with abnormal GCT compared to women with normal glucose tolerance during pregnancy [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Growing number of studies have shown the association of vitamin D deficiency with GDM risk [ 8 , 9 , 10 ]. However, some studies did not confirm this association [ 11 , 12 , 13 ] and even revealed a positive association of 25-hydroxyvitamin D (25(OH)D) level with glucose concentration during pregnancy [ 14 ]. Several meta-analyses found an association between low maternal serum 25(OH)D levels and GDM [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Status and Gestational Diabetes in Russian Pregnant Women in the Period between 2012 and 2021: A Nested Case–Control Study

et al. 2022

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Several meta-analyses found an association between low maternal serum 25-hydroxyvitamin D (25(OH)D) level and gestational diabetes mellitus (GDM). However, some of them reported significant heterogeneity. We examined the association of serum 25(OH)D concentration measured in the first and in the second halves of pregnancy with the development of GDM in Russian women surveyed in the periods of 2012–2014 and 2018–2021. We conducted a case–control study (including 318 pregnant women) nested on two previous studies. In 2012–2014, a total of 214 women (83 GDM and 131 controls) were enrolled before 15 weeks of gestation and maternal serum 25(OH)D concentrations were measured twice: at 8th–14th week of gestation and simultaneously with two-hour 75 g oral glucose tolerance test (OGTT) at 24th–32nd week of gestation. In the period of 2018–2021, 104 women (56 GDM and 48 controls) were included after OGTT and 25(OH)D concentrations were measured at 24th–32nd week of gestation. Median 25(OH)D levels were 20.0 [15.1–25.7] vs. 20.5 [14.5–27.5] ng/mL (p = 0.565) in GDM and control group in the first half of pregnancy and 25.3 [19.8–33.0] vs. 26.7 [20.8–36.8] ng/mL (p = 0.471) in the second half of pregnancy, respectively. The prevalence rates for vitamin D deficiency (25(OH)D levels <20 ng/mL) were 49.4% and 45.8% (p = 0.608) in the first half of pregnancy and 26.2% vs. 22.1% (p = 0.516) in the second half of pregnancy in women who developed GDM and in women without GDM, respectively. The frequency of vitamin D supplements intake during pregnancy increased in 2018–2021 compared to 2012–2014 (p = 0.001). However, the third trimester 25(OH)D levels and prevalence of vitamin D deficiency (25.5 vs. 23.1, p = 0.744) did not differ in women examined in the periods of 2012–2014 and 2018–2021. To conclude, there was no association between gestational diabetes risk and maternal 25(OH)D measured both in the first and in the second halves of pregnancy. The increased prevalence of vitamin D supplements intake during pregnancy by 2018–2021 did not lead to higher levels of 25(OH)D.

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“…A study from Taiwan has even shown opposite results with the higher levels of 25(OH)D in women with abnormal GCT compared to women with normal glucose tolerance during pregnancy [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D Status and Gestational Diabetes in Russian Pregnant Women in the Period between 2012 and 2021: A Nested Case–Control Study

et al. 2022

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“…[53,54] A report showed that serum Cu was significantly higher than that in controls only in patients with HbA1c >6.5% but not in patients with T2D with HbA1c <6.5%. [55] Furthermore, in the gestational state, high plasma Cu levels were reported to be associated with a significantly increased risk of gestational diabetes mellitus (GDM), [56][57][58][59] or another study found that serum Cu levels were not significantly different between women with and without GDM, only after adjustment for confounding covariants (including other metals such as manganese, lead, calcium, zinc, magnesium), and that women who were underweight (BMI < 18.5) might have a 25% reduced risk of GDM for every 50% increase in the Cu concentration within safe limits. [60] Moreover, a clinical study showed that in addition to serum copper, urine copper were related to the progression of diabetes and its complications.…”

Section: Plasma Coppermentioning

confidence: 99%

“…A significantly increased odds of GDM in association with higher concentrations of plasma Cu (Li et al, 2019) [58] Plasma Cu concentration GDM patients 106 Abnormal GCT remained the significant contributing factor for the elevated levels of 25-OH-vitamin D and Cu during gestation (Chiang et al, 2022) [59] Plasma Cu concentration…”

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confidence: 99%

Copper and Diabetes: Current Research and Prospect

Chang,

2023

Molecular Nutrition Food Res

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Copper is an essential trace metal for normal cellular functions; a lack of copper is reported to impair the function of important copper‐binding enzymes, while excess copper could lead to cell death. Numerous studies have shown an association between dietary copper consumption or plasma copper levels and the incidence of diabetes/diabetes complications. And experimental studies have revealed multiple signaling pathways that are triggered by copper shortages or copper overload in diabetic conditions. Moreover, studies show that treated with copper chelators improve vascular function, maintain copper homeostasis, inhibit cuproptosis, and reduce cell toxicity, thereby alleviating diabetic neuropathy, retinopathy, nephropathy, and cardiomyopathy. However, the mechanisms reported in these studies are inconsistent or even contradictory. This review summarizes the precise and tight regulation of copper homeostasis processes, and discusses the latest progress in the association of diabetes and dietary copper/plasma copper. Further, the study pays close attention to the therapeutic potential of copper chelators and copper in diabetes and its complications, and hopes to provide new insight for the treatment of diabetes.

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The Association of Prenatal Vitamin D Status With Pregnancy and Neonatal Outcomes

Mao,

Yuen,

et al. 2023

Journal of the Endocrine Society

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Context Vitamin D inadequacy is globally prevalent among pregnant women; however, its impact on pregnancy remains inconclusive. Objective This study aims to explore the associations of maternal and umbilical cord serum 25-hydroxyvitamin D (25(OH)D) levels with pregnancy and neonatal outcomes. Method We used archived serum samples from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study participants in the Hong Kong center and assayed maternal 25(OH)D levels at midgestation and umbilical cord 25(OH)D at birth using liquid chromatography–tandem mass spectroscopy. Data regarding pregnancy and perinatal outcomes were extracted from the HAPO study dataset and the hospital computerized medical system. Results Only 247 (16.4%) mothers and 66 (5.0%) neonates met the criteria for vitamin D sufficiency (ie, 25(OH)D ≥ 75 nmol/L). The ratio of umbilical cord to maternal vitamin D levels was positively associated with maternal age and ambient solar radiation at the month of delivery, while negatively associated with maternal serum total 25(OH)D at midgestation (all P < .001). Umbilical cord serum 25(OH)D was independently associated with a lower primary cesarean section rate (OR 0.990, 95% CI 0.982-0.999; P = .032). There were no associations of maternal and umbilical cord 25(OH)D levels with other adverse pregnancy and neonatal outcomes. Conclusion Placental vitamin D transfer was found to be higher with a lower maternal vitamin D level, older maternal age, and higher ambient solar radiation at the time of the delivery. The protective effect of sufficient vitamin D in a cesarean section will require further studies.

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High Levels of 25-OH-Vitamin D and Copper in Pregnant Women with Abnormal Glucose Challenge Test

Cited by 3 publications

References 36 publications

Vitamin D Status and Gestational Diabetes in Russian Pregnant Women in the Period between 2012 and 2021: A Nested Case–Control Study

Vitamin D Status and Gestational Diabetes in Russian Pregnant Women in the Period between 2012 and 2021: A Nested Case–Control Study

Copper and Diabetes: Current Research and Prospect

The Association of Prenatal Vitamin D Status With Pregnancy and Neonatal Outcomes

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