High Level of Uromodulin Increases the Risk of Hypertension: A Mendelian Randomization Study
Ruilian You,
Lanlan Chen,
Lubin Xu
et al.
Abstract:Background: The association of uromodulin and hypertension has been observed in clinical studies, but not proven by a causal relationship. We conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between uromodulin and blood pressure.
Methods:We selected single nucleotide polymorphisms (SNPs) related to urinary uromodulin (uUMOD) and serum uromodulin (sUMOD) from a large Genome-Wide Association Studies (GWAS) meta-analysis study and research in PubMed. Six datasets… Show more
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