High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

Iyevleva, Aglaya G.; Kuligina, Ekatherina Sh.; Mitiushkina, Natalia V.; Togo, Alexandr V.; Miki, Yoshio; Imyanitov, Evgeny N.

doi:10.1007/s10549-011-1845-z

Cited by 26 publications

(20 citation statements)

References 48 publications

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“…MicroRNAs of the let-7 family were also reportedly down-regulated in several types of cancer [30]. We also found that miR-21-5p, the sole up-regulated miRNA in our list, was also previously found to be up-regulated [14,31]. However, changes in the expression of most of the miRNAs in our down-regulated list have not been reported in the literature.…”

Section: Resultssupporting

confidence: 61%

MicroRNA-Regulated Protein-Protein Interaction Networks and Their Functions in Breast Cancer

Lee

Kuo

Chen

et al. 2013

IJMS

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MicroRNAs, which are small endogenous RNA regulators, have been associated with various types of cancer. Breast cancer is a major health threat for women worldwide. Many miRNAs were reported to be associated with the progression and carcinogenesis of breast cancer. In this study, we aimed to discover novel breast cancer-related miRNAs and to elucidate their functions. First, we identified confident miRNA-target pairs by combining data from miRNA target prediction databases and expression profiles of miRNA and mRNA. Then, miRNA-regulated protein interaction networks (PINs) were constructed with confident pairs and known interaction data in the human protein reference database (HPRD). Finally, the functions of miRNA-regulated PINs were elucidated by functional enrichment analysis. From the results, we identified some previously reported breast cancer-related miRNAs and functions of the PINs, e.g., miR-125b, miR-125a, miR-21, and miR-497. Some novel miRNAs without known association to breast cancer were also found, and the putative functions of their PINs were also elucidated. These include miR-139 and miR-383. Furthermore, we validated our results by receiver operating characteristic (ROC) curve analysis using our miRNA expression profile data, gene expression-based outcome for breast cancer online (GOBO) survival analysis, and a literature search. Our results may provide new insights for research in breast cancer-associated miRNAs.

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Section: Resultssupporting

confidence: 61%

MicroRNA-Regulated Protein-Protein Interaction Networks and Their Functions in Breast Cancer

Lee

Kuo

Chen

et al. 2013

IJMS

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“…Several recent studies have demonstrated that the expression of miR-27a is up-regulated in several types of solid tumors, including colon, gastric, cervical and breast cancers [10], [12], [24], [26]. The widespread overexpression of miR-27a in cancer has led to the belief that miR-27a is an oncogenic microRNA.…”

Section: Discussionmentioning

confidence: 99%

MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival

et al. 2012

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BackgroundMicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients.MethodsThe expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization (ISH) and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index. The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation. The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ2 test, and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10.ResultsmiR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 (P<0.001). A reverse correlation between miR-27a and ZBTB10 was also observed in breast cancer tissue samples (rs = −0.478, P<0.001). Furthermore, the expression of miR-27a and ZBTB10 was significantly correlated with clinicopathological parameters, including tumor size, lymph node metastasis and distant metastasis (P<0.05), but not with receptor status. Patients with high miR-27a or low ZBTB10 expression tended to have significantly shorter disease-free survival times (57 months and 53 months, respectively, P <0.001) and overall survival times (58 months and 55 months, respectively, P <0.001). Univariate and multivariate analysis showed that both miR-27a and ZBTB10 were independent prognostic factors of disease-free survival in breast cancer patients (P <0.001), while only miR-27a was an independent predictor of overall survival (P <0.001).ConclusionsHigh miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression.

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“…The introduction of next generation sequencing modalities has rapidly identified several miRNAs, including miR-205, miR-125b, miR-145, and miR-21, which are differentially expressed in breast carcinomas vs. normal breast tissue [102-104]. Interestingly, miR-21 binds to the 3’ untranslated region of CCL20 mRNA initiating its degradation [105].…”

Section: Ccl20 and Breast Cancermentioning

confidence: 99%

Many Roles of CCL20: Emphasis on Breast Cancer

Osuala

Sloane

2014

PDJ

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CCL20 or MIP3α is a small ~8 kDa protein primarily expressed in the liver, colon, prostate, cervix, and skin. The cellular receptor for CCL20 is CCR6. CCl20 unlike many other cytokines only binds CCR6, making the CCL20/CCR6 pathway an attractive drug target. Since the initial discovery of CCL20 in the early 1990's, there has been an increase in the evidence implicating the chemokine and its receptor in a number of diseases, including rheumatoid arthritis and human immunodeficiency virus infection. CCL20 has also been linked to malignancies such as ovarian, colorectal and pancreatic cancers. CCL20 can also attract tumor-promoting immune-suppressive cells to the tumor microenvironment, which may contribute to the immune evasive potential of the tumor and tumor progression.

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High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

Cited by 26 publications

References 48 publications

MicroRNA-Regulated Protein-Protein Interaction Networks and Their Functions in Breast Cancer

MicroRNA-Regulated Protein-Protein Interaction Networks and Their Functions in Breast Cancer

MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival

Many Roles of CCL20: Emphasis on Breast Cancer

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