Abstract:Background
Compelling evidence has indicated a significant association between leukocyte mitochondrial DNA copy number (mtDNAcn) and prognosis of several malignancies in a cancer-specific manner. However, whether leukocyte mtDNAcn can predict the clinical outcome of breast cancer (BC) patients has not been well investigated.
Methods
The mtDNA copy number of peripheral blood leukocytes from 661 BC patients was measured using a Multiplex AccuCopy™Kit… Show more
“…Zhang et al. ( Zhang et al, 2023 ) investigated the correlation between leukocyte mtDNA copy number and clinical outcomes in breast cancer patients, revealing for the first time that high mtDNA copy numbers are associated with worse prognosis in hormone receptor-positive cases. And they proposed using mtDNA copy number as a biomarker to predict prognosis.…”
Section: Mtdna Mutations: a Trigger For Cancerogenesismentioning
“…Zhang et al. ( Zhang et al, 2023 ) investigated the correlation between leukocyte mtDNA copy number and clinical outcomes in breast cancer patients, revealing for the first time that high mtDNA copy numbers are associated with worse prognosis in hormone receptor-positive cases. And they proposed using mtDNA copy number as a biomarker to predict prognosis.…”
Section: Mtdna Mutations: a Trigger For Cancerogenesismentioning
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