Large volcanic eruptions can have major impacts on global climate, affecting both atmospheric and ocean circulation through changes in atmospheric chemical composition and optical properties. The residence time of volcanic aerosol from strong eruptions is roughly 2-3 y. Attention has consequently focused on their short-term impacts, whereas the long-term, ocean-mediated response has not been well studied. Most studies have focused on tropical eruptions; high-latitude eruptions have drawn less attention because their impacts are thought to be merely hemispheric rather than global. No study to date has investigated the long-term effects of high-latitude eruptions. Here, we use a climate model to show that large summer high-latitude eruptions in the Northern Hemisphere cause strong hemispheric cooling, which could induce an El Niño-like anomaly, in the equatorial Pacific during the first 8-9 mo after the start of the eruption. The hemispherically asymmetric cooling shifts the Intertropical Convergence Zone southward, triggering a weakening of the trade winds over the western and central equatorial Pacific that favors the development of an El Niño-like anomaly. In the model used here, the specified high-latitude eruption also leads to a strengthening of the Atlantic Meridional Overturning Circulation (AMOC) in the first 25 y after the eruption, followed by a weakening lasting at least 35 y. The long-lived changes in the AMOC strength also alter the variability of the El Niño-Southern Oscillation (ENSO).high-latitude volcanic eruptions | AMOC-ENSO interaction | volcanism P roxy data (1, 2) suggest that the strong reduction of surface insolation over the tropics associated with tropical volcanic eruptions may increase the likelihood of the El Niño-Southern Oscillation (ENSO) and a consequent reduction of the zonal sea surface temperature (SST) gradient along the equatorial Pacific. Modeling studies do not yield consistent results and show both an El Niño-like (3-5) or La Niña-like (6, 7) anomalies following a tropical eruption. Recent studies have also suggested that volcanic eruptions can have a large imprint on ocean circulation, affecting the strength of the Atlantic Meridional Overturning Circulation (AMOC) (8-12) on 5-to 20-y timescales and inducing ocean heat content (OHC) anomalies (13, 14) that may persist for decades. However, this slow recovery has been questioned and may be an artifact of experimental design (15). Furthermore, all previous work on the climate impact of volcanic eruptions has focused on tropical volcanoes; no studies have addressed the potential effects of high-latitude eruptions on ENSO. Here, we use a coupled atmospheric-ocean-aerosol model 17)] to identify the mechanisms by which high-latitude volcanic eruptions can impact ENSO behavior in both the short term (up to 2-3 y) and long term (approximately half-century), the latter being mediated by volcano-induced changes in ocean circulation.We simulate an extreme high-latitude multistage eruption starting on June 1st. We inject 100 Tg of SO...