High Ki67 Gene Expression Is Associated With Aggressive Phenotype in Hepatocellular Carcinoma
Vicente Ramos-Santillan,
Masanori Oshi,
Erek Nelson
et al.
Abstract:Background
Hepatocellular carcinoma (HCC) with high Ki67 protein expression, the most commonly used cell proliferation marker, is associated with an aggressive biologic phenotype; however, conventional immunostaining is hampered by variability in institutional protocol, specific antibody probe, and by assessor subjectivity. To this end, we hypothesized that Ki67 gene (
MKi67
) expression would identify highly proliferative HCC, and clarify its association with oncologic … Show more
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