High Ki67 Expression has Prognostic Value in Surgically-Resected T3 Gastric Adenocarcinoma

Huang, Guoliang; Chen, Shaoquan; Wang, Daiyong; Wang, Ruohan; Lin, Li‐Ying; Chen, Shuming; Wang, Lie; Huang, Qiuyuan

doi:10.7754/clin.lab.2015.150610

Cited by 18 publications

(23 citation statements)

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“…Some previous studies have reported that high Ki-67 expression was associated with poor OS in GC patients[ 14 , 16 , 22 , 24 , 26 , 32 ]. These original studies have revealed that high Ki-67 expression had a predictive value for prognosis of GC patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis

Luo

Zhang

et al. 2017

Oncotarget

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BackgroundThe prognostic value and clinicopathologic significance of Ki-67 expression in gastric cancer patients was controversial. This meta-analysis was performed to clarify the prognostic value and clinicopathologic significance of Ki-67 expression in gastric cancer patients.Materials and MethodsSeveral electronic databases were searched for eligible studies. The pooled odds ratio (OR), hazard ratios (HR) and 95% confidence interval(CI) were calculated to explore the prognostic value and clinicopathologic significance of Ki-67 expression for disease free survival and overall survival.ResultsTotally 5600 gastric cancer patients from 29 studies were included in this study. High Ki-67 expression was significantly related with Lauren's classification (OR = 1.70; P = 0.001; 95%CI: 1.40-2.06) and tumor size(OR = 1.54; P = 0.006; 95%CI: 1.14-2.09). However, high Ki-67 expression was not significantly associated with lymph node metastasis (OR = 1.37; P = 0.138; 95% CI: 0.90-2.08), tumor stage (OR = 1.31; P = 0.296; 95% CI: 0.79-2.16) and tumor differentiation (OR = 1.03; P = 0.839; 95% CI: 0.78-1.35). The pooled HRs were 1.87(P = 0.001; 95% CI 1.30-2.69) for disease free survival and 1.23(P = 0.005; 95% CI 1.06-1.42) for overall survival.ConclusionsHigh Ki-67 expression may serve as a predictive biomarker for poor prognosis in gastric cancer patients. Stratification by Ki-67 expression may be a consideration for selection of therapeutic regimen and integrated managements.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis

Luo

Zhang

et al. 2017

Oncotarget

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“…Ki-67 is a nuclear protein associated with proliferation that is an established prognostic biomarker in various human tumor types, including breast cancer, lymphoma and neuroendocrine neoplasia (33)(34)(35). Previously, a high Ki-67 index was reported to predict reduced disease-free and overall survival in intestinal-type gastric cancer (35) and advanced gastric cancer (33).…”

Section: Ihc Score (24) ---------------------------------------------mentioning

confidence: 99%

Differential expression of EphA5 protein in gastric carcinoma and its clinical significance

et al. 2019

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The aim of the present study was to evaluate ephrin type-A receptor 5 (EphA5) expression and its clinicopathological significance in gastric cancer. Gastric cancer tissues were analyzed by immunohistochemistry. The association between EphA5 expression and clinicopathological parameters, human epidermal growth factor receptor 2 (HER2) status and Ki-67 proliferation index was statistically analyzed. EphA5 expression was detected in all non-tumor gastric epithelia but was differentially expressed among gastric cancer samples. EphA5 was negatively expressed in 30/110 (27.3%) and positively expressed in 80/110 (72.3%) samples from patients with gastric cancer. EphA5 expression was significantly associated with Lauren classification (P= 0.032), lymph node metastasis (P<0.001), HER2 expression (P=0.020) and Ki-67 expression (P=0.005). No significant association was determined between EphA5 expression and age, sex, primary location, depth of invasion and Tumor-Node-Metastasis stage. The present data indicated that EphA5 is differentially expressed in gastric cancer. EphA5 may therefore be a potential therapeutic target and may have clinical utility as a marker for lymph node metastasis in gastric cancer.

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“…Gastric stem cells with LGR5 expression were only found in the antrum of adult mice, where they drive self-renewal in the stomach and can be used to build long-lived gastric units in vitro [ 40 , 45 ]. Ki67, a nuclear proliferation-associated antigen, is increased in many tumors and correlates with cell proliferation [ 18 ]. Studies have confirmed Ki67 expression in low grade adenoma, high grade adenoma and intestinal-type gastric adenocarcinoma [ 27 ], and its expression is increased in the transformation from GIM to GC [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…GIM patients may eventually progress into intestinal-type GC [ 3 , 13 ]; however, the incidence remains low [ 14 , 15 ], and direct evidence of gastric carcinogenesis from GIM remains elusive. Some proteins, including the gastric cancer stem cell biomarker CD24 [ 16 ], leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5) [ 16 , 17 ] and the cell proliferation biomarker Ki67 [ 18 ], have been reported to be expressed in GIM tissues, and they are postulated to be involved in the progression from GIM to GC [ 15 , 19 , 20 ]. However, no further research has been performed to investigate the relationship of these proteins to GIM.…”

Section: Introductionmentioning

confidence: 99%

Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia

et al. 2017

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Gastric intestinal metaplasia (GIM) is a precancerous gastric carcinoma (GC) lesion with pivotal roles in carcinogenesis. CD24, LGR5 and Ki67 are expressed in GIM; we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. Sixteen patients with intestinal-type GC were enrolled in this study. GIM was determined according to the updated Sydney system; GIM classification was determined via HID-AB staining, and AQP3, CD24, LGR5 and Ki67 expression were determined by immunohistochemistry. Type III GIM was more prevalent around the GC and displayed a positive association with GIM severity. CD24 was found in GIM, but LGR5 and Ki67 were found in tissues regardless of GIM. AQP3 expression showed significant correlation to type III GIM. CD24 expression was correlated with the marked GIM and incomplete GIM, while LGR5 expression decreased with GIM aggravation and did not have relationship with classification of GIM. However, Ki67 presented no association with GIM grade or classification. These observations identify AQP3 and CD24 as biomarkers for carcinogenesis of GIM, and may provide a precise strategy for screening at-risk candidates with GIM.

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High Ki67 Expression has Prognostic Value in Surgically-Resected T3 Gastric Adenocarcinoma

Cited by 18 publications

References 0 publications

Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis

Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis

Differential expression of EphA5 protein in gastric carcinoma and its clinical significance

Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia

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