High-k dielectric Al2O3 nanowire and nanoplate field effect sensors for improved pH sensing

Abstract

Over the last decade, field-effect transistors (FETs) with nanoscale dimensions have emerged as possible label-free biological and chemical sensors capable of highly sensitive detection of various entities and processes. While significant progress has been made towards improving their sensitivity, much is yet to be explored in the study of various critical parameters, such as the choice of a sensing dielectric, the choice of applied front and back gate biases, the design of the device dimensions, and many others. In this work, we present a process to fabricate nanowire and nanoplate FETs with Al2O3 gate dielectrics and we compare these devices with FETs with SiO2 gate dielectrics. The use of a high-k dielectric such as Al2O3 allows for the physical thickness of the gate dielectric to be thicker without losing sensitivity to charge, which then reduces leakage currents and results in devices that are highly robust in fluid. This optimized process results in devices stable for up to 8 h in fluidic environments. Using pH sensing as a benchmark, we show the importance of optimizing the device bias, particularly the back gate bias which modulates the effective channel thickness. We also demonstrate that devices with Al2O3 gate dielectrics exhibit superior sensitivity to pH when compared to devices with SiO2 gate dielectrics. Finally, we show that when the effective electrical silicon channel thickness is on the order of the Debye length, device response to pH is virtually independent of device width. These silicon FET sensors could become integral components of future silicon based Lab on Chip systems.

Silicon nanowire biosensor and its applications in disease diagnostics: A review

“…To produce nanowire structures, top-down technologies use nanofabrication tools such as e-beam lithography [10,13,22,29,[40][41][42][43][44][45][46][47][48], lithographically patterned NW electrodeposition (LPNE) [49], nano-stencil lithography [50], or nanoimprint lithography [51]. Various sizes of NWs have been produced by the e-beam lithography-based methods, with typical widths of 50 nm and lengths ranging from 20 m to 1 mm [10,22].…”

Ultralocalized thermal reactions in subnanoliter droplets-in-air

“…Further advances of these technologies require the ability to integrate additional elements, such as the miniaturized heating element described here, and the ability to integrate heating elements in a massively parallel format compatible with silicon technology (26). Notably, our miniaturized heaters could also function as dual heater/sensor elements, as these SOI nanowire or nanoribbon structures have been used to detect DNA, proteins, pH, and pyrophosphates (27)(28)(29)(30)(31).…”

Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices

“…Full details of the device response to pH and other surface modifications are described in previous publications from the Bashir group. 29 …”