High intracolonic acetaldehyde values produced by a bacteriocolonic pathway for ethanol oxidation in piglets.

High Salivary Acetaldehyde After a Moderate Dose of Alcohol in ALDH2‐Deficient Subjects: Strong Evidence for the Local Carcinogenic Action of Acetaldehyde

“…2 it also can be calculated that a systemic ethanol level of about 40 mM, which represents heavy alcohol intoxication, results in salivary acetaldehyde levels of about 90 M in nonflushers and 170 M in flushers. Earlier, we demonstrated similar or even higher acetaldehyde levels after a moderate dose of alcohol in the gastric juice of subjects with iatrogenic achlorhydria and gastric bacterial overgrowth (Väkeväinen et al, 1999), as well as in the colonic contents of pigs (Jokelainen et al, 1996). Accordingly, acetaldehyde produced locally in the digestive tract from either endogenous or ingested ethanol may be a general carcinogen in the gastrointestinal tract.…”

Ethanol-derived Microbial Production of Carcinogenic Acetaldehyde in Achlorhydric Atrophic Gastritis

“…The characteristics of microbially mediated acetaldehyde production from ethanol both in vitro and in vivo have been established in several studies (8,11,12,24,(35)(36)(37)(38)(39)(40)(41). In our very recent study, we were able to demonstrate that iatrogenic hypochlorhydri a in the stomach leads to intragastric microbial acetaldehyde production from ingested ethanol in healthy volunteers with an age range of 21-25 years (8).…”

Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism

“…The reduction of aerobic gastrointestinal flora with ciprofloxacin decreases total ethanol elimination by a rate of about 10% both in rats and in man [38][39][40]. This is associated with a significant decrease in the mean ADH activity of fecal samples, in almost total abolishment of the formation of endogenous ethanol in the colon, and in a remarkable reduction of the intracolonic AA production from ethanol [39,40].…”