High intracellular calcium amounts inhibit activation-induced proliferation of mouse T cells
Joel P Joseph,
Tanisha Kumar,
Kaushik Chatterjee
et al.
Abstract:Optimal T cell activation is critical to orchestrate adaptive immune responses. Calcium is critical for T cell activation and integrates signaling pathways necessary to activate key transcription factors. In fact, patients with calcium channelopathies are immunodeficient. Here, we investigated the effects of different concentrations of intracellular calcium on activation of mouse T cells. High intracellular calcium amounts inhibitedin vitroT cell proliferation as evidenced by a decreased cell cycling-to-hypodi… Show more
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