High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1

Kowalewska, Beata; Zorena, Katarzyna; Szmigiero-Kawko, Małgorzata; Wąż, Piotr; Myśliwiec, Małgorzata

doi:10.1155/2016/4685976

Cited by 7 publications

(8 citation statements)

References 46 publications

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“…Also, this higher growth may disrupt the ecological balance of intestinal flora, which occurs in type 1 DM [37]. Regarding the gastrointestinal colonization, Kowalewska et al [38] studied the serum levels of interleukin-12 (IL12) in relation to the percentage of yeast-like fungi colonies residing in the gastrointestinal tract in children and adolescents with DM type 1. Results showed that high IL12 levels can inhibit infection with yeast-like fungal colonizing the gastrointestinal tract in children and adolescents with type 1 DM.…”

Section: Introductionmentioning

confidence: 99%

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Candida sp. Infections in Patients with Diabetes Mellitus

Rodrigues

Henriques

2019

JCM

202

161

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Candidiasis has increased substantially worldwide over recent decades and is a significant cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus (DM) is a metabolic disorder that predisposes individuals to fungal infections, including those related to Candida sp., due to a immunosuppressive effect on the patient. This review aims to discuss the latest studies regarding the occurrence of candidiasis on DM patients and the pathophysiology and etiology associated with these co-morbidities. A comprehensive review of the literature was undertaken. PubMed, Scopus, Elsevier’s ScienceDirect, and Springer’s SpringerLink databases were searched using well-defined search terms. Predefined inclusion and exclusion criteria were applied to classify relevant manuscripts. Results of the review show that DM patients have an increased susceptibility to Candida sp. infections which aggravates in the cases of uncontrolled hyperglycemia. The conclusion is that, for these patients, the hospitalization periods have increased and are commonly associated with the prolonged use of indwelling medical devices, which also increase the costs associated with disease management.

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Section: Introductionmentioning

confidence: 99%

“…Results showed that high IL12 levels can inhibit infection with yeast-like fungal colonizing the gastrointestinal tract in children and adolescents with type 1 DM. However, further studies are needed to confirm the antifungal activity of IL12 [38].…”

Section: Introductionmentioning

confidence: 99%

Candida sp. Infections in Patients with Diabetes Mellitus

Rodrigues

Henriques

2019

JCM

202

161

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“…The levels of TNF-alpha were significantly higher in the young diabetic patients in the study compared to the control group. Some studies have also found an association between cytokine levels and the duration of type 1 diabetes [ 22 , 62 , 63 ]. In the Norwegian Atherosclerosis and Childhood Diabetes prospective study, the analysis of TNF-α and IL-18 levels, among others, showed that the early, low-grade inflammation present in young people with T1D five years after diagnosis persists through ten years of disease, with moderate changes in most inflammatory markers over time [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have shown a significant positive correlation between TNF-α and HbA 1c [ 65 ]. On the other hand, some studies have demonstrated a significant negative correlation between the levels of IL-12 [ 63 ], IL-35 [ 49 ], and HbA 1c levels. Similarly to our results, Al-Dubayee et al found no significant relationship between higher levels of HbA 1c and TNF-α IL-4 or IL-10 and the HbA 1c level [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes

Neubauer-Geryk,

Wielicka,

Myśliwiec

et al. 2024

IJMS

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Metabolic memory refers to the long-term effects of achieving early glycemic control and the adverse implications of high blood glucose levels, including the development and progression of diabetes complications. Our study aimed to investigate whether the phenomenon of metabolic memory plays a role in the immune profile of young patients with uncomplicated type 1 diabetes (T1D). The study group included 67 patients with uncomplicated type 1 diabetes with a mean age of 15.1 ± 2.3 years and a minimum disease duration of 1.2 years. The control group consisted of 27 healthy children and adolescents with a mean age of 15.1 ± 2.3 years. Patients were divided into three groups according to their HbA1c levels at the onset of T1D, and the average HbA1c levels after one and two years of disease duration. The subgroup A1 had the lowest initial HbA1c values, while the subgroup C had the highest initial HbA1c values. Cytokine levels (including TNF-α, IL-35, IL-4, IL-10, IL-18, and IL-12) were measured in all study participants. Our data analysis showed that subgroup A1 was characterized by significantly higher levels of IL-35 and IL-10 compared to all other groups, and significantly higher levels of IL-4 compared to group B. Additionally, a comparative analysis of cytokine levels between the groups of diabetic patients and healthy controls demonstrated that subgroup A1 had significantly higher levels of anti-inflammatory cytokines. The lipid profile was also significantly better in subgroup A1 compared to all other patient groups. Based on our findings, it appears that an inflammatory process, characterized by an imbalance between the pro- and anti-inflammatory cytokines, is associated with poor glycemic control at the onset of diabetes and during the first year of disease duration. These findings also suggest that both metabolic memory and inflammation contribute to the abnormal lipid profile in patients with type 1 diabetes.

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“…Pathogenesis: Candidal vaginitis is a generic term used for vaginal infections caused by Candida species. Candida albicans is responsible for 90% of vulvovaginal candidiasis; the remaining 10% corresponds to C. glabrata and C. Tropicalis 11 Candida albicans colonizes the genital tract of 10 -55% women in the childbearing age group. Most studies show increased rates of vaginal colonization in women infected with HIV.…”

Section: Chronic Vulvovaginal Candidiasismentioning

confidence: 99%

Untitled

2020

IJPSR

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The fungus candida with over 355 species is an anamorphic yeast. It consists of over 20 human pathogenic species which are the cause of candidiasis. Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systematic and potentially lifethreatening diseases. Candida species are opportunistic human pathogens which despite treatment with antifungal drugs can cause fatal infections in immune-compromised and immune-deficient patients. C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, together account for about 95% of identifiable Candida infections. C. albicans, considered to be the most serious cause of candidiasis, is a diploid, polymorphic yeast producing three morphologic forms: yeast cells, pseudohyphae, and true hyphae. This phenotypic switching plays a vital role in virulence. Since invasive yeast infections are associated with high levels of morbidity and mortality so rapid and accurate identification can contribute to successful therapy, earlier resolution of infections and subsequent reduction of moribund outcomes. CHROM agar candida, a type of chromogenic medium, based on speciesspecific enzyme activity, has been found to be a medium of choice for isolation and identification of candida species from clinical samples. This review is mainly focused on the diversity of candida, its polymorphism and various identification techniques used for proper diagnosis and prevention of candida infection, thus improving the prognosis for a wide range of patients. INTRODUCTION: Candida is the 6 th most common nosocomial (hospital-related) pathogen in the United States and the fourth most frequent cause of bloodstream infections. Infections due to candida and other yeast have increased dramatically in recent years and are of particular importance because of the rising number of immuno-compromised individuals and due to the countless medical advances available in medical sciences for QUICK RESPONSE CODE

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High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1

Cited by 7 publications

References 46 publications

Candida sp. Infections in Patients with Diabetes Mellitus

Candida sp. Infections in Patients with Diabetes Mellitus

The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes

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