High Intensity Treadmill Running Reduces Tumour Hypoxia in Mice.

Lønbro, Simon; Elming, P.B.; Wittenborn, Thomas; Horsman, Michael R.

doi:10.1249/01.mss.0000536854.65128.64

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite exercising for more than twice the amount of time (45 vs. 20 min), the mice in the experiment by Schadler et al [ 67 ] only exercised at half the intensity (10 vs. 20 m/min), which likely resulted in overall lower mean arterial pressure compared to the experiment by Miller et al [ 66 ] and therefore could have resulted in lower tumour perfusion pressure and hence lower tumour blood flow. Indeed, preliminary data from Lønbro et al [ 68 ] suggest that it is only high-intensity exercise and not low- or moderate-intensity exercise that results in decreased intratumoral hypoxia.…”

Section: Exercise Modulation Of Tumour Perfusion and Hypoxiamentioning

confidence: 99%

Exercise modulation of tumour perfusion and hypoxia to improve radiotherapy response in prostate cancer

Schumacher

Galvão

Taaffe

et al. 2020

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Background An increasing number of studies indicate that exercise plays an important role in the overall care of prostate cancer (PCa) patients before, during and after treatment. Historically, research has focused on exercise as a modulator of physical function, psychosocial well-being as well as a countermeasure to cancer-and treatment-related adverse effects. However, recent studies reveal that exercise may also directly influence tumour physiology that could beneficially affect the response to radiotherapy. Methods In this narrative review, we provide an overview of tumour vascular characteristics that limit the effect of radiation and establish a rationale for exercise as adjunct therapy during PCa radiotherapy. Further, we summarise the existing literature on exercise as a modulator of tumour perfusion and hypoxia and outline potential future research directions. Results Preclinical research has shown that exercise can reduce intratumoral hypoxia-a major limiting factor in radiotherapy-by improving tumour perfusion and vascularisation. In addition, preliminary evidence suggests that exercise training can improve radiotherapy treatment outcomes by increasing natural killer cell infiltration in a murine PCa model. Conclusions Exercise is a potentially promising adjunct therapy for men with PCa undergoing radiotherapy that may increase its effectiveness. However, exercise-induced tumour radiosensitisation remains to be confirmed in preclinical and clinical trials, as does the optimal exercise prescription to elicit such effects.

show abstract

Section: Exercise Modulation Of Tumour Perfusion and Hypoxiamentioning

confidence: 99%