High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice

Wang, Ningning; Liu, Yang; Ma, Yanan; Wen, Deliang

doi:10.1016/j.lfs.2017.08.023

Cited by 92 publications

(79 citation statements)

References 46 publications

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“…Indeed, in the present study, we found that 8 weeks of HIIT decreased fasting blood glucose and serum insulin concentrations in T2DM mice and improved glucose and insulin tolerance. These results are similar to the earlier finding that 8 weeks of HIIT improved glucose tolerance and reduced the systemic glucose and serum insulin concentrations of obese mice (26). Human studies also showed that glucose tolerance was significantly improved in 16 young men following sessions of HIIT, which each involved 4-6 thirty second sprint cycles (49).…”

Section: Discussionsupporting

confidence: 89%

“…Moreover, data from the present study revealed that the serum TG in T2DM-HIIT mice was significantly lower than that observed in T2DM-SED mice; however, HIIT did not affect TC, HDL-C, or LDL-C content. In contrast, Wang et al reported that HIIT lowered the levels of TG, TC and LDL-C in obese mice (26). This difference may be due to differences in the animal models used in the two studies.…”

Section: Discussionmentioning

confidence: 90%

“…Besides, regular exercise also has been used as an adjuvant therapy to reduce body weight and improve lipid metabolism in obese (52) and subjects with type 2 diabetes (4). Previous studies have shown that 8 weeks of HIIT reduced body weight and fat mass and increased lean mass in obese mice (26). Studies in humans have also revealed that HIIT significantly improved the body weight, fat percentage and BMI of persons with type 2 diabetes (53).…”

Section: Discussionmentioning

confidence: 98%

“…All mice in the T2DM-HIIT group performed the exercise training program on a mouse treadmill at 25 • inclination five times a week for 8 weeks, as described previously with little modification (26). The mice in the T2DM-HIIT group started with a warm-up at 5 m/min for 10 min, in which the HIIT consisted of 10 rounds of 4 min of high-intensity treadmill running interspersed with 2 min of complete rest.…”

Section: Exercise Protocolmentioning

confidence: 99%

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High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes

et al. 2020

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High-intensity interval training has been reported to lower fasting blood glucose and improve insulin resistance of type 2 diabetes without clear underlying mechanisms. The purpose of this study was to investigate the effect of high-intensity interval training on the glycolipid metabolism and mitochondrial dynamics in skeletal muscle of high-fat diet (HFD) and one-time 100 mg/kg streptozocin intraperitoneal injection-induced type 2 diabetes mellitus (T2DM) mice. Our results confirmed that high-intensity interval training reduced the body weight, fat mass, fasting blood glucose, and serum insulin of the T2DM mice. High-intensity interval training also improved glucose tolerance and insulin tolerance of the T2DM mice. Moreover, we found that high-intensity interval training also decreased lipid accumulation and increased glycogen synthesis in skeletal muscle of the T2DM mice. Ultrastructural analysis of the mitochondria showed that mitochondrial morphology and quantity were improved after 8 weeks of high-intensity interval training. Western blot analysis showed that the expression of mitochondrial biosynthesis related proteins and mitochondrial dynamics related proteins in high-intensity interval trained mice in skeletal muscle were enhanced. Taken together, these data suggest high-intensity interval training improved fasting blood glucose and glucose homeostasis possibly by ameliorating glycolipid metabolism and mitochondrial dynamics in skeletal muscle of the T2DM mice.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Exercise Protocolmentioning

confidence: 99%

See 2 more Smart Citations

High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes

et al. 2020

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“…Reduced adipocyte size and number with exercise training are expected to accompany weight loss [53] and concomitant increase in energy expenditure [54][55][56]. We found little change in body weight with exercise, although the histological changes within scWAT are indicative of a catabolic state.…”

Section: Discussionmentioning

confidence: 55%

The Impact of Moderate-Intensity Continuous or High-Intensity Interval Training on Adipogenesis and Browning of Subcutaneous Adipose Tissue in Obese Male Rats

et al. 2020

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This study compares the effect of two types of exercise training, i.e., moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) on the browning of subcutaneous white adipose tissue (scWAT) in obese male rats. Effects on fat composition, metabolites, and molecular markers of differentiation and energy expenditure were examined. Forty male Wistar rats were assigned to lean (n = 8) or obese (n = 32) groups and fed either a standard chow or high-fat obesogenic diet for 10 weeks. Eight lean and obese rats were then blood and tissue sampled, and the remaining obese animals were randomly allocated into sedentary, MICT, or HIIT (running on a treadmill 5 days/week) groups that were maintained for 12 weeks. Obesity increased plasma glucose and insulin and decreased irisin and FGF-21. In scWAT, this was accompanied with raised protein abundance of markers of adipocyte differentiation, i.e., C/EBP-α, C/EBP-β, and PPAR-γ, whereas brown fat-related genes, i.e., PRDM-16, AMPK/SIRT1/PGC-1α, were reduced as was UCP1 and markers of fatty acid transport, i.e., CD36 and CPT1. Exercise training increased protein expression of brown fat-related markers, i.e., PRDM-16, AMPK/SIRT1/PGC-1α, and UCP1, together with gene expression of fatty acid transport, i.e., CD36 and CPT1, but decreased markers of adipocyte differentiation, i.e., C/EBP-α, C/EBP-β, and plasma glucose. The majority of these adaptations were greater with HIIT compared to MICT. Our findings indicate that prolonged exercise training promotes the browning of white adipocytes, possibly through suppression of adipogenesis together with white to beige trans-differentiation and is dependent on the intensity of exercise.

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Role of peripheral myelin protein 22 in chronic exercise‐induced interactions of muscle and bone in mice

Kawaguchi

Kawao

Muratani

et al. 2022

Journal Cellular Physiology

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Exercise is important for the prevention and treatment of sarcopenia and osteoporosis.Although the interactions between skeletal muscles and bone have recently been reported, the myokines linking muscle to bone during exercise remain unknown. We previously revealed that chronic exercise using treadmill running blunts ovariectomyinduced osteopenia in mice. We herein performed an RNA sequence analysis of the gastrocnemius and soleus muscles of male mice with or without chronic exercise to |

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High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice

Cited by 92 publications

References 46 publications

High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes

High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes

The Impact of Moderate-Intensity Continuous or High-Intensity Interval Training on Adipogenesis and Browning of Subcutaneous Adipose Tissue in Obese Male Rats

Role of peripheral myelin protein 22 in chronic exercise‐induced interactions of muscle and bone in mice

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