High-intensity interval training relieves osteoarthritis-induced neuropathic pain through promoting the polarization of M1 to M2 in microglia via the Jak2/Stat3 pathway in rats
Abstract:Objective: Osteoarthritis (OA)-induced neuropathic pain is closely related to microglial polarization in the central nervous system. This study aimed to determine whether high-intensity interval training (HIIT) could relieve neuropathic pain and promote the polarization of M1 to M2 in microglia through the Jak2/Stat3 pathway in OA rats. Methods: Wistar rats received intra-articular injection of monosodium iodoacetate for an OA model. After four weeks, moderate-intensity continuous training (MICT) or HIIT was c… Show more
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