High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats

Khakdan, Soheyla; Delfan, Maryam; Meymeh, Maryam Heydarpour; Kazerouni, Faranak; Ghaedi, Hamid; Shanaki, Mehrnoosh; Kalaki-Jouybari, Fatemeh; Gorgani‐Firuzjaee, Sattar; Rahimipour, Ali

doi:10.1080/13813455.2018.1511599

Cited by 17 publications

(24 citation statements)

References 44 publications

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“…15 Also, Khakdan et al demonstrated that HIIT intervention effectively improved heart function in an miR195 dependent manner and alleviated high-fat, high-fructose diet-induced cardiomyopathy in diabetic rats. 13 The main finding of this study was that the HFD considerably increased M1 markers and exercise interventions reversed them. More importantly, HIIT intervention was more effective.…”

Section: Discussionmentioning

confidence: 60%

“…Today, new training protocols, such as high-intensity interval training (HIIT), have been developed for the management of metabolic diseases. 13 Ample evidence has revealed that an HIIT program has beneficial effects on the management of metabolic diseases, such as polycystic ovary syndrome, obesity, fatty liver, and DM. 14 Our previous studies focused on the underlying mechanism of the beneficial effect of continuous endurance training (CET) and HIIT on glycemic control and hypolipidemic impacts in HFD-induced diabetic rats by targeting microRNAs.…”

Section: Introductionmentioning

confidence: 99%

“…The results demonstrated that exercise intervention, especially HIIT, efficiently alleviated antidiabetic and hypolipidemic markers. 13,15 Recent evidence indicates that HIIT can improve insulin sensitivity and metabolic syndrome; however, the molecular mechanism of HIIT effects has not yet been well-defined. 16 Adipose-tissue inflammation is essential among several molecular mechanisms of the beneficial effects of training.…”

Section: Introductionmentioning

confidence: 99%

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<p>High-Intensity Interval Training Reversed High-Fat Diet–Induced M1-Macrophage Polarization in Rat Adipose Tissue via Inhibition of NOTCH Signaling</p>

Shanaki¹,

Khosravi²,

Khoshdooni-Farahani³

et al. 2020

JIR

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Introduction: There is accumulating evidence on the beneficial effect of exercise intervention in the management of metabolic disorders; however, the molecular mechanism is still unclear. Here, the current study aimed to compare the effect of high-intensity interval training (HIIT) and continuous endurance training (CET) on serum and adipose-tissue markers of M1/M2 macrophage polarization. Methods: A total of 45 healthy male Wistar rats were divided into groups of normal chow (n=10) and high-fat diet (HFD) (n=35). Then, rats receiving the HFD were randomly divided into four groups. Training programs were performed for 5 days/week over 10 weeks. The CET protocol included 30 minutes running at 50%-60% of VO 2max . The HIIT protocol consisted of five repeated intervals of 2-minute sprints on the treadmill at 80%-90% VO 2max workload with 1 minute's 30%-35% VO 2max interval for each rat. Then, biochemical parameters were assessed. Macrophage-polarization markers were assessed at mRNA and protein levels by real-time PCR and Western blotting, respectively. Results: Both exercise-training programs, especially HIIT, reversed increased serum biochemical parameters (glucose, triglycerides, cholesterol, Homeostatic Model Assessment of Insulin Resistance, and hsCRP), M1-polarization markers (circulating IL6, TNFα, and adipose-tissue mRNA expression of IL6, TNFα and iNOS), M2 markers (CD206, CD163, and IL10 expression), as well as pIκKB, pNFκB, and NICD expression in HFD-induced diabetes. Conclusion: Our findings suggest that despite devoting less time, the HIIT workout is a more effective intervention for diabetes management. Moreover, HIIT reverses HFD-induced macrophage polarization by targeting the NFκB and NOTCH signaling pathways.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>High-Intensity Interval Training Reversed High-Fat Diet–Induced M1-Macrophage Polarization in Rat Adipose Tissue via Inhibition of NOTCH Signaling</p>

Shanaki¹,

Khosravi²,

Khoshdooni-Farahani³

et al. 2020

JIR

Self Cite

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“…Kanter et al [92] reported the therapeutic effects of low-intensity exercise against apoptotic, biochemical, and morphological changes in cardiac tissues. Khakdan et al [93] showed that high-intensity interval training increased the expression of Sirtuin 1 (Sirt1) and BCL-2 and significantly improved the left ventricular ejection fraction (LVEF) and fractional shortening (FS). Furthermore, studies have revealed that exercise improves diabetes via inhibition of endoplasmic reticulum (ER) stress-induced apoptosis; however, the extent of such inhibition depends on the intensity of exercise [9].…”

Section: Apoptosis Of Cardiomyocytesmentioning

confidence: 99%

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Seo

Jang

et al. 2019

IJMS

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Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

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“…Kanter et al showed that low intensity exercise had a therapeutic effect on diabetes-induced morphological, biochemical, and apoptotic changes in the cardiac tissue of rats (51). Khakdan et al found that high intensity interval training effectively increased the expression of Sirtuin 1 (Sirt1) and B cell leukemia/lymphoma 2 (BCL-2) in diabetic rats, with improved left ventricular ejection fraction (LVEF%) and fractional shortening (FS%) (57). A recent study suggested that exercise appeared to ameliorate DCM by inhibiting endoplasmic reticulum stress-induced apoptosis in diabetic rats, which was in an intensity-dependent manner (52).…”

Section: Pre-clinical Experiments About Physical Exercise and Dcmmentioning

confidence: 99%

Physical Exercise and Its Protective Effects on Diabetic Cardiomyopathy: What Is the Evidence?

Zheng

Cheng²,

Zheng

et al. 2018

Front. Endocrinol.

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As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical exercise can delay or prevent the complications of diabetes. Current studies show that physical exercise has been regarded as an importantly non-pharmacological treatment for diabetes and DCM, with high efficacy and low adverse events. It can inhibit the pathological processes of myocardial apoptosis, myocardial fibrosis, and myocardial microvascular diseases through improving myocardial metabolism, enhancing the regulation of Ca2+, and protecting the function of mitochondria. Eventually, it can alleviate the occurrence and development of diabetic complications. Describing the mechanisms of physical exercise on DCM may provide a new theory for alleviating, or even reversing the development of DCM, and prevent it from developing to heart failure.

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High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats

Cited by 17 publications

References 44 publications

<p>High-Intensity Interval Training Reversed High-Fat Diet–Induced M1-Macrophage Polarization in Rat Adipose Tissue via Inhibition of NOTCH Signaling</p>

<p>High-Intensity Interval Training Reversed High-Fat Diet–Induced M1-Macrophage Polarization in Rat Adipose Tissue via Inhibition of NOTCH Signaling</p>

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Physical Exercise and Its Protective Effects on Diabetic Cardiomyopathy: What Is the Evidence?

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