High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial

Alizadeh, Ali Mohammad; Isanejad, Amin; Sadighi, Sanambar; Mardani, Mahta; Kalaghchi, Bita; Hassan, Zuhair Mohammad

doi:10.1007/s00432-019-02996-y

Cited by 32 publications

(87 citation statements)

References 52 publications

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“…Due to limitations in the accessibility of human samples, peripheral blood is often the only tissue compartment from which immune cells or inflammatory mediators are assessed in clinical studies. Over half (53%) of the studies evaluating a PA intervention in the post treatment period reported a reduction in at least one inflammatory cytokine (IL-6, IL-8, CRP, MIF, TNFα, and HMGB-1) in plasma or serum ( 61 , 62 , 65 , 66 , 68 , 70 , 73 , 74 , 78 , 79 ). However, no study measured all of these inflammatory mediators in the same patients and some studies found no effect of the PA intervention on one or more of these cytokines within the same study.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators

Rogers

2020

Front. Nutr.

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There is strong evidence that physical activity (PA) reduces risk, recurrence, and mortality from breast cancer. Emerging data suggest that PA induces changes in inflammatory and immune mediators that may contribute to beneficial effects on breast cancer outcomes. Thus, the goal of this review was to evaluate the evidence linking the protective benefit of PA to modulation of immune responses in breast cancer. A literature search was conducted to identify studies that evaluated the impact of PA on tumor and immune outcomes in breast cancer patients and in mammary tumor models. Nineteen studies investigated the effect of PA interventions on cancer immune outcomes using preclinical breast cancer models. Tumor growth was reduced in 11 studies, unchanged in three studies, and increased in one study. Spontaneous metastasis was reduced in two studies and survival was improved in four studies. Frequently assessed immune outcomes include splenic cell number and function, circulating inflammatory cytokines, and intratumoral immune cells and inflammatory markers. Circulating inflammatory cytokine responses were heterogeneous in preclinical models. Within the tumor microenvironment (TME), several studies documented a change in the infiltration of immune cells with an increase in effector cells and a reduction in immune suppressive cells. Twenty-three studies investigated the effect of PA interventions on immune outcomes in breast cancer patients. Thirteen studies used aerobic PA interventions and 10 studies used a combination of aerobic and resistance exercise interventions. Cycling and treadmill activities were the most commonly used PA modalities. Circulating immune cells and inflammatory cytokines were the most frequently assessed immune outcomes in the clinical studies. Among the 19 studies that evaluated a PA intervention during the post treatment period, 10 reported a reduction in the levels of at least one inflammatory cytokine. No inflammatory cytokines were quantified in the three studies that evaluated a PA intervention during treatment with chemotherapy. Immune outcomes within the tumor were assessed in only one study performing a PA intervention prior to surgery. Results from preclinical and clinical studies suggest that PA exerts heterogeneous effects on inflammatory cytokines, but may alter the gene expression profile and immune infiltrates in the tumor which may result in a reduction in immunosuppressive factors. However, additional studies are needed to better understand the effect of PA on immune outcomes in the TME.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators

Rogers

2020

Front. Nutr.

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“…Three of the 13 studies did not specify who supervised the intervention. In those that did specify, the supervisor was an exercise trainer [9][10][11][12], an exercise physiologist [13][14][15][16][17][18], or an oncology nurse [13][14][15][16]. In Mijwel et al, the intervention was supervised by an exercise physiologist or oncology nurse.…”

Section: Exercise Supervisionmentioning

confidence: 99%

“…These studies likely selected a cycle ergometer because they decided to use VO 2 max as an indicator of exercise intensity during training in order to evaluate safety and feasibility of HIIT during breast cancer treatment, and a cycle ergometer allows for quanti cation of work. The mode of training in studies in cancer survivors was a treadmill in 3 studies [17,18,22], cycling in 1 study [21], and outdoor walking in 1 study [20]. Almost all past studies of HIIT in subjects other than breast cancer survivors used equipment that allows for quanti cation of work (e.g., a cycle ergometer or treadmill) because VO 2 max was set as the indicator of exercise intensity.…”

Section: Type Of Exercisementioning

confidence: 99%

“…Mijwel et al, who investigated combination of HIIT plus resistance training or aerobic training, observed no change in fatigue evaluated by the PFS [13]. Alizadeh AM et al found that HIIT signi cantly reduced levels of interleukin (IL)-6 [18]. In summary, there is insu cient evidence regarding the effects of HIIT on HRQOL and fatigue.…”

Section: Cardiotoxicity and Cardiovascular Functionmentioning

confidence: 99%

“…For HIIT, participants performed 3 sets consisting of 3 min of exercise on a cycle ergometer at an intensity of 85% to 100% VO 2 max followed by 1 min of active rest. For resistance training, they performed 8 to 12 repetitions of resistance training exercises for major muscle groups at 60% to 80% 1RM.In the group of studies involving interventions after initial breast cancer treatment, Alizadeh AM et al and Alizadeh S had participants perform 4 sets consisting of 4 min of inclined running at an intensity of 90% to 95% HRmax followed by 3 min of passive rest, repeated 3 times weekly for 12 weeks[17,18]. Northey et al had participants perform 4 sets consisting of 30 s of maximum-intensity pedaling followed by 2 min of rest, repeated 3 times weekly for 12 weeks[21].…”

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confidence: 99%

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Exploration of High-Intensity Interval Training for Breast Cancer Survivors: Taking a Home-based Approach Toward New Normal

Tsuji¹,

Matsuoka²,

Ochi³

2020

Preprint

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BackgroundTo review the methods and outcomes of high-intensity interval training (HIIT) interventions for breast cancer survivors, and to explore the feasibility of prescribing exercise for breast cancer survivors.MethodsA systematic search of electronic databases was conducted for studies published up to May 31, 2020. Eligibility criteria included randomized controlled trials of HIIT intervention in breast cancer survivors. Studies were grouped by whether the intervention was conducted during or after breast cancer treatment, and intervention methods and outcomes were reviewed within each group.Results Twenty-six studies were identified, and 13 satisfied the inclusion criteria. Intervention was conducted during treatment in 8 studies, and after treatment in 5. Intervention duration ranged from 3 to 16 weeks, with 2 or 3 sessions per week, for a total of 9 to 36 sessions. All interventions were supervised; 12 were lab-based, and 1 was community-based. One of most promising outcomes was improvement of cardiorespiratory fitness by HIIT.ConclusionThis review found that most studies on HIIT for breast cancer survivors investigated lab-based, supervised interventions. HIIT is a time-efficient method for increasing cardiovascular function in breast cancer survivors, but further research is necessary to determine its effects on other outcomes.

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High‐intensity interval training in breast cancer patients: A systematic review and meta‐analysis

Chen,

Shi,

et al. 2023

Cancer Medicine

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BackgroundWomen with breast cancer and improved survival often experience treatment‐related impairments. High‐intensity interval training (HIIT) has emerged as a promising exercise therapy modality for adult cancer patients. However, the overall effects of HIIT in breast cancer patients remain scarce and controversial. Therefore, we conducted a systematic review and meta‐analysis to comprehensively evaluate the impact of HIIT on health‐related outcomes in breast cancer patients.MethodsWe searched the PubMed, Embase, and Web of Science from inception to November 7, 2022. Eligible studies included randomized controlled trials that compared HIIT interventions with usual care (UC) or MICT in breast cancer patients. The primary outcome assessed was physical fitness, and exploratory outcomes included body composition, blood‐borne biomarkers, and patient‐reported outcomes. Summary data were extracted, and standardized mean differences (SMD) were calculated for meta‐analysis. For outcomes that could not be pooled, a systematic review was conducted.ResultsOur analysis included 19 articles from 10 studies, encompassing 532 participants who met the inclusion criteria. Pooled results demonstrated that HIIT was superior to UC in improving peak oxygen uptake (VO2peak). The SMD for VO2peak (L/min) and VO2peak (mL/kg/min) was 0.79 (95% CI 0.13, 1.45) and 0.59 (95% CI 0.01, 1.16), respectively. No significant differences in VO2peak were found between the HIIT and MICT groups. Meta‐analyses on body composition and blood‐borne biomarkers showed no significant differences between HIIT and UC. Systematic review indicated favorable effects of HIIT on muscle strength, fatigue, and emotional well‐being.ConclusionsHIIT is a time‐efficient alternative to MICT for improving VO2peak and may also enhance muscle strength and alleviate fatigue and emotional symptoms in breast cancer patients. HIIT should be considered as an important component of exercise prescription in breast cancer care. Further studies with larger cohorts are needed to determine the clinical significance of HIIT‐induced changes in terms of other outcomes in women with breast cancer.

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High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial

Cited by 32 publications

References 52 publications

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators

Exploration of High-Intensity Interval Training for Breast Cancer Survivors: Taking a Home-based Approach Toward New Normal

High‐intensity interval training in breast cancer patients: A systematic review and meta‐analysis

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