High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males

Abstract

Introduction: Sleep deprivation can impair several physiological systems and recently, new evidence has pointed to the relationship between a lack of sleep and carbohydrate metabolism, consequently resulting in insulin resistance. To minimize this effect, High-Intensity Interval Training (HIIT) is emerging as a potential strategy.Objective: The aim of this study was to investigate the effects of HIIT on insulin resistance induced by sleep deprivation.Method: Eleven healthy male volunteers were recruited, aged 18–35 years, who declared taking 7–8 h sleep per night. All volunteers were submitted to four different conditions: a single night of regular sleep (RS condition), 24 h of total sleep deprivation (SD condition), HIIT training followed by regular sleep (HIIT+RS condition), and HIIT training followed by 24 h of total sleep deprivation (HIIT+SD condition). They performed six training sessions over 2 weeks and each session consisted of 8–12 × 60 s intervals at 100% of peak power output. In each experimental condition, tests for glucose, insulin, cortisol, free fatty acids, and insulin sensitivity, measured by oral glucose tolerance test (OGTT), were performed.Results: Sleep deprivation increased glycaemia and insulin levels, as well as the area under the curve. Furthermore, an increase in free fatty acids concentrations and basal metabolism was observed. There were no differences in the concentrations of cortisol. However, HIIT before 24 h of sleep deprivation attenuated the increase of glucose, insulin, and free fatty acids.Conclusion: Twenty-four hours of sleep deprivation resulted in acute insulin resistance. However, HIIT is an effective strategy to minimize the deleterious effects promoted by this condition.

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

“…14 Prior studies show improvements in work capacity and performance alike. 15,16 Sleep apnea (SA) is a respiratory disorder that occurs at night with symptoms that may be present during daytime as well. 17 Three forms of sleep apnea exist, including Obstructive Sleep Apnea (OSA), Central Sleep Apnea (CSA), and Mixed Sleep Apnea (MSA).…”

Impaired Insulin Profiles Following a Single Night of Sleep Restriction: The Impact of Acute Sprint Interval Exercise

“…Exercise appears to be a promising intervention to alleviate the impairment in insulin sensitivity following total sleep deprivation. Two weeks of high-intensity exercise training has been shown to attenuate the insulin response to an oral glucose tolerance test after one night of total sleep deprivation (de Souza et al, 2017). However, it remains unclear if a single bout of exercise performed after partial SR can produce similar outcomes.…”

The effects of partial sleep deprivation and the sub-maximal NDKS exercise testing protocol on S-Klotho and hemodynamic responses in women

“…Sleep deprivation (acute and/or chronic) is well documented as an influence of function and performance in both healthy and clinical populations, across sex and age to different extents. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The present study demonstrates a clear and significant influence of partial sleep deprivation on S-Klotho responses to the sub-maximal NDKS exercise test in young, healthy, and trained women, while compared to being non-sleep deprived. The data of this study suggest that partial sleep deprivation of 20hours, is a strong enough stressor, resulting in lower levels of S-Klotho immediate-post, and post-dynamic recovery, while compared to those of the non-sleep deprived state.…”

“…[10][11][12][13] On the other hand, exercise and adaptation to exercise of various exercise modalities such as aerobic training, and resistance training have been proven to negate part and/or all of the adverse effects of sleep deprivation in humans and rats. [14][15][16][17] S-Klotho is an enzyme that in humans is encoded by the KL gene. 18 S-klotho is a type I membrane protein first documented in 1997.…”