High intensity focused ultrasound (HIFU) ablation of porous liver: Numerical analysis of heat transfer and hemodynamics

Mohammadpour, M.; Firoozabadi, Bahar

doi:10.1016/j.applthermaleng.2020.115014

Cited by 13 publications

(5 citation statements)

References 48 publications

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“…Further, the increase in porosity in the LTNE model can result in the increase in the maximum temperature and in the drop in the percentage of effective treatment area, which is in accordance with the results discussed in [40]. The evaluation methods for equivalent thermal dose, CEM43 and CEM43-VTF, can lead to different necrosis doses, which has also been validated in previous works [13,26]. Nevertheless, previous reports did not compare different thermal dose evaluation methods by considering different bio-heat transfer models based on a real experimental image, which is the main contribution of this work.…”

Section: Influence Of Bio-tissue Porosity On Therapeutic Effectsupporting

confidence: 86%

“…The heat transfer for biological tissue is usually predicted by the classical Pennes bio-heat transfer (PBHT) equation due to its simplicity [9][10][11]. However, Pennes model ignores the large blood vessels with significant heat effect and the change of blood temperature, since it generally assumes a constant blood temperature and the thermal balance of surrounding tissue [12,13]. Contrary to the PBHT model, both bio-tissue and blood temperature are assumed to be different in local thermal nonequilibrium (LTNE) equation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of porous heat transfer model on different equivalent thermal dose methods considering an experiment-based nanoparticle distribution during magnetic hyperthermia

Tang

Wang

Flesch

et al. 2023

J. Phys. D: Appl. Phys.

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Magnetic fluid hyperthermia damages malignant cells by keeping the therapeutic temperature within a specific range after magnetic nanoparticles (MNPs) are exposed to an alternating magnetic field. The temperature distribution inside bio-tissue is usually predicted by a classic Pennes bio-heat transfer equation, which considers a heat source due to a homogeneous distribution for MNPs. Aiming at this problem, this study compares the Pennes model to a porous heat transfer model, named local thermal non-equilibrium equation, by considering an experiment-based MNPs distribution, and evaluates the thermal damage degree for malignant tissue by two different thermal dose methods. In addition, this study evaluates the effect of porosity and different blood perfusion rates on both effective treatment temperature and equivalent thermal dose. Simulation results demonstrate that different bio-heat transfer models can result in significant differences in both the treatment temperature profile and the thermal damage degree for tumor region under the same power dissipation of MNPs. Furthermore, scenarios considering a temperature-dependent blood perfusion rate or a lower porosity can have a positive effect on the temperature distribution inside tumor, while having a lower value in the maximum equivalent thermal dose in both thermal dose evaluation methods.

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Section: Influence Of Bio-tissue Porosity On Therapeutic Effectsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effect of porous heat transfer model on different equivalent thermal dose methods considering an experiment-based nanoparticle distribution during magnetic hyperthermia

Tang

Wang

Flesch

et al. 2023

J. Phys. D: Appl. Phys.

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“…Meanwhile, if a major blood vessel or artery is ruptured and the hemorrhage cannot be controlled, it is especially critical in closed procedures and may be life-threatening. Thus, this risk requires extensive investigation to better understand and improve the efficacy and safety of HIFU treatment [ 6 , 7 , 8 ]. In the published literature, there are discrepancies in such adverse effects observed in clinics.…”

Section: Introductionmentioning

confidence: 99%

Influence of High-Intensity Focused Ultrasound (HIFU) Ablation on Arteries: Ex Vivo Studies

Zhou

Lim

2021

Micromachines

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High-intensity focused ultrasound (HIFU) has been used to ablate solid tumors and cancers. Because of the hypervascular structure of the tumor and circulating blood inside it, the interaction between the HIFU burst and vessel is a critical issue in the clinical environment. Influences on lesion production and the potential of vessel rupture were investigated in this study for the efficiency and safety of clinical ablation. An extracted porcine artery was embedded in a transparent polyacrylamide gel phantom, with bovine serum albumin (BSA) as an indicator of the thermal lesion, and degassed water was driven through the artery sample. The HIFU focus was aligned to the anterior wall, middle of the artery, and posterior wall. After HIFU ablation, the produced lesion was photographically recorded, and then its size was quantified and compared with that in the gel phantom without artery. In addition, the bubble dynamics (i.e., generation, expansion, motion, and shrinkage of bubbles and their interaction with the artery) were captured using high-speed imaging. It was found that the presence of the artery resulted in a decrease in lesion size in both the axial and lateral directions. The characteristics of the lesion are dependent on the focus alignment. Acoustic and hydrodynamic cavitation play important roles in lesion production and interaction with the artery. Both thermal and mechanical effects were found on the surface of the artery wall after HIFU ablation. However, no vessel rupture was found in this ex vivo study.

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“…As hard tissue is significantly thicker than soft tissue, the radius of curvature of bone and skull tissue is larger than that of soft tissue. The absorbent layer's thickness is adjusted between 4 and 12 mm for a variety of tissues [39,40]. Nevertheless, the absorption capacity of bone and skull tissues is lower so that they are thicker than other tissues.…”

Section: Resultsmentioning

confidence: 99%

Non-Invasive Heat-Induced Numerous Tissue Ablation Simulation in a Medical Environment Using Different Focal Length High Intensity Focused Ultrasound Apparatus

Naziba¹,

Uddin

2022

AJSE

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In the field of biomedical, HIFU is a non-invasive therapeutic method that employs non-ionizing acoustic waves to increase the temperature. According to its high efficiency and cheap cost, it has been the main focus of this research. The key stages of this tumor ablation include mechanical and thermal effects. Simulations on tissue ablation with HIFU were implemented in this research to investigate how multiple tissue ablation works and how to enhance tumor ablation while avoiding injury to surrounding healthy tissue by altering the optimal intensity, power, focal length and lens radius of curvature. In order to find the optimal features of the proposed model, this analysis employs clinical applications. Numerous soft and hard tissues from the human body were chosen for this analysis. At a specified acoustic power and exposure period, each tissues optimal frequency (1.6 MHz to 3.5 MHz) and power (120 W to 140 W) were obtained for effective tissue ablation. This research performed all computations by changing the focal length from 55 mm to 65 mm. The outcomes of this therapy might require several weeks to comfortably remove tumor. This optimum result indicates that HIFU tumor ablation procedure has a high probability of success.

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High intensity focused ultrasound (HIFU) ablation of porous liver: Numerical analysis of heat transfer and hemodynamics

Cited by 13 publications

References 48 publications

Effect of porous heat transfer model on different equivalent thermal dose methods considering an experiment-based nanoparticle distribution during magnetic hyperthermia

Effect of porous heat transfer model on different equivalent thermal dose methods considering an experiment-based nanoparticle distribution during magnetic hyperthermia

Influence of High-Intensity Focused Ultrasound (HIFU) Ablation on Arteries: Ex Vivo Studies

Non-Invasive Heat-Induced Numerous Tissue Ablation Simulation in a Medical Environment Using Different Focal Length High Intensity Focused Ultrasound Apparatus

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