High-Intensity Focused Ultrasound (HIFU) for Specific Therapeutic Treatments: A Literature Review

Evans, Kevin D.; Weiss, Brandon; Knopp, Michael

doi:10.1177/8756479307307268

Cited by 38 publications

(22 citation statements)

References 27 publications

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“…In addition to the devices approved by the FDA for clinical use, there are several procedures that are being investigated for clinical application 36 . High‐intensity focused ultrasound application in therapy and treatment of disease is one of the more active areas of research and development among all of the nonionizing energy modalities such as radiofrequency, lasers, and microwaves.…”

Section: Therapeutic Applications Of Ultrasound Based On Heatingmentioning

confidence: 99%

Overview of Therapeutic Ultrasound Applications and Safety Considerations

Miller

Smith

Bailey

et al. 2012

Journal of Ultrasound in Medicine

536

380

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Summary Applications of ultrasound in medicine for therapeutic purposes have been an accepted and beneficial use of ultrasonic biological effects for many years. Low power ultrasound of about 1 MHz frequency has been widely applied since the 1950s for physical therapy in conditions such as tendinitis or bursitis. In the 1980s, high pressure-amplitude shockwaves came into use for mechanically resolving kidney stones, and “lithotripsy” rapidly replaced surgery as the most frequent treatment choice. The use of ultrasonic energy for therapy continues to expand, and approved applications now include uterine fibroid ablation, cataract removal (phacoemulsification), surgical tissue cutting and hemostasis, transdermal drug delivery, and bone fracture healing, among others. Undesirable bioeffects can occur including burns for thermal-based therapies and significant hemorrhage for mechanical-based therapies (e. g. lithotripsy). In all these therapeutic applications for bioeffects of ultrasound, standardization, ultrasound dosimetry, benefits assurance and side-effects risk minimization must be carefully considered in order to insure an optimal benefit to risk ratio for the patient. Therapeutic ultrasound typically has well-defined benefits and risks, and therefore presents a tractable safety problem to the clinician. However, safety information can be scattered, confusing or subject to commercial conflict of interest. Of paramount importance for managing this problem is the communication of practical safety information by authoritative groups, such as the AIUM, to the medical ultrasound community. In this overview, the Bioeffects Committee outlines the wide range of therapeutic ultrasound methods, which are in clinical use or under study, and provides general guidance for assuring therapeutic ultrasound safety.

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Section: Therapeutic Applications Of Ultrasound Based On Heatingmentioning

confidence: 99%

Overview of Therapeutic Ultrasound Applications and Safety Considerations

Miller

Smith

Bailey

et al. 2012

Journal of Ultrasound in Medicine

536

380

View full text Add to dashboard Cite

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“…HIFU has been described as a potentially effective nonionizing therapy for a variety of benign and malignant tumours (115,(117)(118)(119)(120)(121)(122)(123). However, to the best of our knowledge, no cases of the use of HIFU in the management of adrenal tumors have been reported yet (70).…”

Section: High Intensity Focused Ultrasound (Hifu)mentioning

confidence: 99%

Interventional radiology of the adrenal glands: current status

et al. 2018

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As more and more adrenal neoplasms are found incidentally or symptomatically, the need for interventional procedures has being increasing. In recent years these procedures registered continued steady expansion. Interventional radiology of the adrenal glands comprises angiographic and percutaneous procedures. They may be applied both in benign and in malignant pathologies. The present review reports the current status of indications, techniques results and complications of the image-guided procedures.

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“…High intensity focused ultrasound (HIFU) was recently approved by the FDA for ablative treatment of essential tremor in the USA [1,2]. Developing low intensity applications include opening of the blood-brain barrier (BBB) and direct ultrasonic neuromodulation and stimulation (UNMS).…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of simulated transcranial ultrasound fields to acoustic medium property maps

et al. 2017

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Abstract.High intensity transcranial focused ultrasound is an FDA approved treatment for essential tremor, while low-intensity applications such as neurostimulation and opening the blood brain barrier are under active research. Simulations of transcranial ultrasound propagation are used both for focusing through the skull, and predicting intracranial fields. Maps of the skull acoustic properties are necessary for accurate simulations, and can be derived from medical images using a variety of methods. The skull maps range from segmented, homogeneous models, to fully heterogeneous models derived from medical image intensity. In the present work, the impact of uncertainties in the skull properties is examined using a model of transcranial propagation from a single element focused transducer. The impact of changes in bone layer geometry and the sound speed, density, and acoustic absorption values is quantified through a numerical sensitivity analysis. Sound speed is shown to be the most influential acoustic property, and must be defined with less than 4% error to obtain acceptable accuracy in simulated focus pressure, position, and volume. Changes in the skull thickness of as little as 0.1 mm can cause an error in peak intracranial pressure of greater than 5%, while smoothing with a 1 mm 3 kernel to imitate the effect of obtaining skull maps from low resolution images causes an increase of over 50% in peak pressure. The numerical results are confirmed experimentally through comparison with sonications made through 3D printed and resin cast skull bone phantoms.

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High-Intensity Focused Ultrasound (HIFU) for Specific Therapeutic Treatments: A Literature Review

Cited by 38 publications

References 27 publications

Overview of Therapeutic Ultrasound Applications and Safety Considerations

Overview of Therapeutic Ultrasound Applications and Safety Considerations

Interventional radiology of the adrenal glands: current status

Sensitivity of simulated transcranial ultrasound fields to acoustic medium property maps

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