High Intensity Focused Ultrasound for Treatment of Bone Malignancies—20 Years of History

Yeo, Sin Yuin; Bratke, Grischa; Grüll, Holger

doi:10.3390/cancers15010108

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…The initial success of ultrasound in any disease management process was the non-invasiveness and better spatiotemporal resolution with deeper tissue penetration compared to other imaging or therapeutic technologies [ 69 ]. In the case of pain management due to cancer or any other ailments, the influence of ultrasound was significant and is considered the better alternative to analgesic medications, behavioral treatments, or other types of physical neurostimulation (magnetic or electrical) [ 8 ]. Based on our bibliometric analyses, the future of cancer management depends on ultrasound and its developments.…”

Section: Discussionmentioning

confidence: 99%

“…HIFU was utilized in several clinical studies involving the management of various complications during tumor/metastases conditions. The major success of HIFU was observed in the management of bone metastasis-induced pain by neuromodulation at the PNS level [ 7 , 8 ]. Reduction of pain sensation was reported after 3–14 days, and pain medication can be discontinued after the relief.…”

Section: Introductionmentioning

confidence: 99%

“…At the Central nervous system (CNS) level, clinical trials on HIFU-mediated medial or central lateral thalamotomies for neuropathic pain management were successfully conducted with long-term efficacies. Neuromodulation at the Peripheral nervous system (PNS) has given great success for the US-based management of cancer-induced pain [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Ultrasound in Cancer and Cancer-Related Pain—A Bibliometric Analysis and Future Perspectives

Sridharan,

Sharma,

Lim

2023

Sensors

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Ultrasound has a deep penetrating ability with minimal or no tissue injury, while cancer-mediated complications during diagnosis, therapy, and surgery have become a serious challenge for clinicians and lead to the severity of the primary condition (cancer). The current study highlights the importance of ultrasound imaging and focused ultrasound therapy during cancer diagnosis, pain reduction, guidance for surgical resection of cancer, and the effectiveness of chemotherapy. We performed the bibliometric analysis on research domains involving ultrasound, cancer management, pain, and other challenges (chemotherapy, surgical guidance, and postoperative care), to observe the trend by which the research field has grown over the years and propose a possible future trend. The data was obtained from the Web of Science, processed, and exported as plain text files for analysis in the Bibliometrix R web interface using the Biblioshiny package. A total of 3248 documents were identified from 1100 journal sources. A total of 390 articles were published in 2022, with almost a 100% growth rate from previous years. Based on the various network analysis, we conclude that the outcome of the constant research in this domain will result in better patient care during the management of various diseases, including cancer and other co-morbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Ultrasound in Cancer and Cancer-Related Pain—A Bibliometric Analysis and Future Perspectives

Sridharan,

Sharma,

Lim

2023

Sensors

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“…Chemotherapy [8], immunotherapy [9], inhibitory therapy [10], and surgery [11] are the standard treatments for OS. Without proper treatments, OS diseases will progress to malignant tumours [12]. Over the course of five years, the overall and event-free survival Disclaimer/Publisher's Note: The statements, opinions, and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

Zaidi¹,

Haque²,

Miskon³

2023

Preprint

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There has been no significant efficacy in treatment for osteosarcoma (OS) metastasis after nearly four decades of trials. This motivates us to elucidate OS therapies according to their four bidirectional mutation stages. To refresh the OS therapy status quo, the historical developments and clinical advancements are briefly described. However, the main issue of metastasis remains unresolved, accounting for 90% of pulmonary metastasis deaths. Thus, this metastasis problem is related to immune evasion and chemoresistance that are being induced after long-term treatment by the use of immunotherapy for tumorigenesis. Therefore, it is rationale to discuss the relationship cycles of mutation stages including tumorigenesis, metastasis, immune evasion, and chemoresistance. Even though many combinational and targeted therapies have been developed to intensify these mutation treatments, successful clinical translations with higher cure rates are still rare. Through this review, an in-depth understanding of the bidirectional relationship between the four OS mutation stages and their respective therapies is provided. Herein, we summarise the medicines used to treat tumorigenesis, including COLGALT2 inhibitors, Tra2B, and AGAP1, miR-148a and miR-21-5p EVs, and the lncRNA LIFR-AS1. Following the medicines used to treat metastasis are AXL, miR-135a-5p, mRNA BCL6, TGFβ1, Tim-3, SOCS5, CASC15, KLF3-AS1, PDCD4, ATG5, and Rab22a-NeoF1. Then the medicines used to treat immune evasion are N-cadherin, anti-IL-9, USP12 inhibitor, IgG-4+ B-cells, LAP inhibitor, anti-Wnt2 mAb, anti-αvβ8 integrin, HK2-mediated IκBα, IDO inhibitor with NO, and TGF-βRII with anti-IgG1. Finally, the medicines used to treat chemoresistance are DHFR, FPGS, HSP-90AA1, XCT-790, ATKI, and IGF1. As a result, this contribution is expected to serve as a reference and guide for scientists and clinicians.

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Update on musculoskeletal applications of magnetic resonance-guided focused ultrasound

McGill,

Baal,

Bucknor

2024

Skeletal Radiol

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Magnetic resonance-guided focused ultrasound (MRgFUS) is a noninvasive, incisionless, radiation-free technology used to ablate tissue deep within the body. This technique has gained increased popularity following FDA approval for treatment of pain related to bone metastases and limited approval for treatment of osteoid osteoma. MRgFUS delivers superior visualization of soft tissue targets in unlimited imaging planes and precision in targeting and delivery of thermal dose which is all provided during real-time monitoring using MR thermometry. This paper provides an overview of the common musculoskeletal applications of MRgFUS along with updates on clinical outcomes and discussion of future applications.

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High Intensity Focused Ultrasound for Treatment of Bone Malignancies—20 Years of History

Cited by 4 publications

References 52 publications

The Role of Ultrasound in Cancer and Cancer-Related Pain—A Bibliometric Analysis and Future Perspectives

The Role of Ultrasound in Cancer and Cancer-Related Pain—A Bibliometric Analysis and Future Perspectives

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

Update on musculoskeletal applications of magnetic resonance-guided focused ultrasound

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