High-Intensity Focused Ultrasound Ablation for Postoperative Recurrent Desmoid Tumors: Preliminary Results

Mo, Shaojiang; Chen, Jinyun; Zhang, Rong; Yang, Chao; Wang, Ting; Chen, Li; Chen, Wenzhi

doi:10.1016/j.ultrasmedbio.2021.12.002

Cited by 5 publications

(9 citation statements)

References 32 publications

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“…The mean days of hospitalization ranged from 0.12 to 7.0, and the mean follow-up after treatment ranged from 3.8 to 53.8 months. A total of 21 studies ( 12 - 14 , 18 - 32 , 34 , 36 , 37 ) reported the locations of ablated DF tumors, of which 12 studies used cryoablation, 8 studies used HIFU, and 1 study used MWA. In terms of location, 425 (72.6%) tumors were located in the extra-abdominal area, 69 (11.8%) tumors were located in the intra-abdominal area, and 91 (15.6%) tumors were located at chest wall or abdominal wall.…”

Section: Resultsmentioning

confidence: 99%

“…The mean diameter of tumors ablated with cryoablation was 7.61 cm (95% CI: 6.62–8.74), the mean diameter of tumors ablated with HIFU was 10.29 cm (95% CI: 9.11–11.63), and the mean diameter of the tumors ablated with MWA was 10.90 cm ( 14 ). A total of 14 studies ( 12 - 14 , 22 , 24 - 27 , 29 - 31 , 34 , 36 , 37 ) reported the mean volume of the ablated DF tumors. The mean volume of the tumors ablated with cryoablation was 189.54 cm 3 (95% CI: 111.76–321.45), the mean diameter of the tumors ablated with HIFU was 211.47 cm 3 (95% CI: 92.66–482.63), and the mean diameter of the tumors ablated with MWA was 212.7 cm 3 ( 14 ).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and safety of different thermal ablative therapies for desmoid-type fibromatosis: a systematic review and meta-analysis

Huang,

Hong,

Luo

et al. 2023

Quant Imaging Med Surg

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Background Desmoid-type fibromatosis (DF) is a locally aggressive tumor characterized by peripheral infiltration of neoplastic cells and remote metastasis disability. This systematic review examined the efficacy and safety of thermal ablative therapy for DF tumors. Methods A literature search was conducted using PubMed, Web of Science, Cochrane Library, and Embase from January 1, 2000, to November 12, 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used to guide literature selection. The inclusion criteria were the following: (I) the patients were diagnosed with aggressive fibromatosis pathologically, (II) the patients were treated by thermal ablations, and (III) a focus on treatment efficacy and safety. Meanwhile, the exclusion criteria were the following: (I) cohorts of patients with hypertrophic scar, Gardner fibroma, or nodular fasciitis; (II) conference abstracts, reviews, case reports, letters to editors, comments, or editorials; (III) number of patients <5; (IV) in vitro or animal experiments; and (V) non-English language articles. The inverse variance method with a random effects model was used to obtain the pooled data. Subgroup analyses were performed to identify treatment factors. Egger test was conducted to assess the risk of publication bias. Results After literature selection, 694 DF tumors were identified in 23 studies. In terms of modality, 13 studies used cryoablation, 9 studies used high-intensity focused ultrasound (HIFU), and 1 study used microwave ablation (MWA). The pooled symptom relief rate was 90% [95% confidence interval (CI): 80–97%], with that for HIFU being 100% (95% CI: 85–100%), that for cryoablation being 87% (95% CI: 74–97%), and that MWA being 89% (95% CI). The pooled major complication rate was 3% (95% CI: 1–7%), and that for each modality was as follows: HIFU =2% (95% CI: 0–6%), cryoablation =4% (95% CI: 1–8%), MWA =11%, ultrasound =6% (95% CI: 1–13%), computed tomography (CT) =2% (95% CI: 0–7%), and magnetic resonance imaging (MRI) =3% (95% CI: 0–14%). The pooled nonperfused volume rate (NPVR) was 76% (95% CI: 71–81%), and that for each modality was as follows: HIFU =77% (95% CI: 71–85%), cryoablation =74% (95% CI: 69–79%), ultrasound =75% (95% CI: 67–83%), CT =76% (95% CI: 67–87%), and MRI =78% (95% CI: 70–87%). The pooled local control rate was 88% (95% CI: 79–94%) and that for each modality was as follows: HIFU =99% (95% CI: 96–100%), cryoablation =80% (95% CI: 68–90%), and MWA =78%. The differences in major complication rate (P=0.77) and NPVR between imaging-guided modalities (P=0.40) were not significant, nor were the differences in symptom relief rate (P=0.32) and major complication rate (P=0.61) between ablative techniques; however, the differences in local control rate (P=0.01) were significant between ablative techniques. Conclusions Imaging-guided thermal ablative therapies contribute t...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of different thermal ablative therapies for desmoid-type fibromatosis: a systematic review and meta-analysis

Huang,

Hong,

Luo

et al. 2023

Quant Imaging Med Surg

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“…Significant coagulative necrosis was observed in all patients with greater than fifty percent reduction of tumor volume and no major complications. Since then, multiple additional case series have been published with similar results for both extra and intra-abdominal desmoid tumors treated with ultrasound guided High intensity focused ultrasound [ 44 , 45 , 46 ].…”

Section: Ablationmentioning

confidence: 99%

Role of the Interventional Radiologist in the Treatment of Desmoid Tumors

Goldberg

Woodhead

Hannallah

et al. 2023

Life

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Desmoid tumors are locally aggressive soft tissue tumors with variable clinical presentation. As is the case with most relatively rare tumors, a multidisciplinary team approach is required to best manage these patients. Surgical resection, systemic therapy, and radiation therapy have classically been mainstays of treatment for desmoid tumors; however, a more conservative “wait-and-see” approach has been adopted given their high recurrence rates and significant morbidity associated with the aforementioned therapies. Given the challenges of classical treatment methods, interventional radiologists have begun to play a significant role in minimally invasive interventions for desmoid tumors. Herein, the authors review imaging characteristics of desmoid tumors, current management recommendations, and minimally invasive therapeutic intervention options.

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“…Aggressive chemotherapy should be avoided because it is associated with significant morbidities. However, cytotoxic chemotherapy, non-cytotoxic systemic therapy and targeted therapy have been revealed as part of different treatment regimens [ 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. Cytotoxic chemotherapy is usually the first treatment option for rapidly growing and symptomatic unresectable or advanced diseases.…”

Section: Clinical Presentation and Treatmentmentioning

confidence: 99%

“…Recent progress regarding DT biology and molecular pathways has led to the development of promising novel biological agents. In any case, a multidisciplinary approach is required and is gradually employed, especially in intra-abdominal DTs [ 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. In addition, recent studies in the literature have shown that EADTs, following a correct surgical excision of the lesion with undamaged surgical margins, have a low rate of local recurrence and distant metastasis.…”

Section: Clinical Presentation and Treatmentmentioning

confidence: 99%

Multimodality Imaging Assessment of Desmoid Tumors: The Great Mime in the Era of Multidisciplinary Teams

Simonetti

Bruno

Fusco

et al. 2022

JPM

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Desmoid tumors (DTs), also known as desmoid fibromatosis or aggressive fibromatosis, are rare, locally invasive, non-metastatic soft tissue tumors. Although histological results represent the gold standard diagnosis, imaging represents the fundamental tool for the diagnosis of these tumors. Although histological analysis represents the gold standard for diagnosis, imaging represents the fundamental tool for the diagnosis of these tumors. DTs represent a challenge for the radiologist, being able to mimic different pathological conditions. A proper diagnosis is required to establish an adequate therapeutic approach. Multimodality imaging, including ultrasound (US), computed tomography (CT) and Magnetic Resonance Imaging (MRI), should be preferred. Different imaging techniques can also guide minimally invasive treatments and monitor their effectiveness. The purpose of this review is to describe the state-of-the-art multidisciplinary imaging of DTs; and its role in patient management.

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High-Intensity Focused Ultrasound Ablation for Postoperative Recurrent Desmoid Tumors: Preliminary Results

Cited by 5 publications

References 32 publications

Efficacy and safety of different thermal ablative therapies for desmoid-type fibromatosis: a systematic review and meta-analysis

Efficacy and safety of different thermal ablative therapies for desmoid-type fibromatosis: a systematic review and meta-analysis

Role of the Interventional Radiologist in the Treatment of Desmoid Tumors

Multimodality Imaging Assessment of Desmoid Tumors: The Great Mime in the Era of Multidisciplinary Teams

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