High-intensity focused ultrasound ablation assisted using color Doppler imaging for the treatment of hepatocellular carcinomas

Abstract

PurposeWe evaluated the usefulness of color Doppler flow imaging to compensate for the inadequate resolution of the ultrasound (US) monitoring during high-intensity focused ultrasound (HIFU) for the treatment of hepatocellular carcinoma (HCC).Materials and methodsUS-guided HIFU ablation assisted using color Doppler flow imaging was performed in 11 patients with small HCC (<3 lesions, <3 cm in diameter). The HIFU system (Chongqing Haifu Tech) was used under US guidance. Color Doppler sonographic studies were performed using an HIFU 6150S US imaging unit system and a 2.7-MHz electronic convex probe.ResultsThe color Doppler images were used because of the influence of multi-reflections and the emergence of hyperecho. In 1 of the 11 patients, multi-reflections were responsible for the poor visualization of the tumor. In 10 cases, the tumor was poorly visualized because of the emergence of a hyperecho. In these cases, the ability to identify the original tumor location on the monitor by referencing the color Doppler images of the portal vein and the hepatic vein was very useful. HIFU treatments were successfully performed in all 11 patients with the assistance of color Doppler imaging.ConclusionColor Doppler imaging is useful for the treatment of HCC using HIFU, compensating for the occasionally poor visualization provided by B-mode conventional US imaging.

Destructive effect of HIFU on rabbit embedded endometrial carcinoma tissues and their vascularities

“…Ultrasonic CDFI detected blood stream imagine of uterine tumor vasculature before and after HIFU ablation when needed. The imaging of uterine tumor vasculature detected by ultrasonic CDFI was in agreement with microvessel density count of UEA I label, both methods confirmed HIFU ablation effect to uterine tumor vasculature [ 18 ].…”

“…Tumor vascular perfusion and microcirculation could be detected by contrast agents in vivo . The latter was especially important in research of antiangiogenic treatment [ 18 ].…”

High intensity focused ultrasound (HIFU) applied to hepato-bilio-pancreatic and the digestive system—current state of the art and future perspectives

“…A total of 67 articles were identified and were included for data extraction. From this pool, 46 were included for quantitative analysis and the remaining for qualitative analysis (Figure 1).…”

Advances in equipment for tumor sonodynamic therapy

“…Vaezy等人 [30] 通过二者的同步触发解决了 这一问题, 形成了HIFU治疗期间的实时成像引导系 统. Jeong等人 [22] [36] . 因此 也有研究团队 [37] [38] . 而声辐射力 弹性成像则是通过体外用于治疗的聚焦超声束产生 的声辐射力使组织发生微小位移或变形, 并利用超 声弹性成像的原理获得组织的应变分布 [38] .…”