High intensity focused ultrasound ablation of kidney guided by MRI

Damianou, Christakis; Pavlou, Menelaos; Velev, O; Kyriakou, K; Trimikliniotis, Michael

doi:10.1016/j.ultrasmedbio.2003.10.018

Cited by 61 publications

(31 citation statements)

References 44 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, cavitation activity is better detected by T2-weighted FSE, while T1-weighted FSE produces a poor contrast between air and necrotic tissues Damianou 2004). Damianou et al (2004) found that there is a significant difference in signal intensity between air spaces (cavitation bubble) and necrosis tissues, and water-filled air spaces appear brighter than thermal lesions using T2-weighted FSE. Figure 7.45 shows various MR images in a pig kidney with T2-weighted FSE using different ablation exposures.…”

Section: Magnetic Resonance Cavitation Imagingmentioning

confidence: 99%

Cavitation Imaging in Tissues

Zhong

Chen

et al. 2015

Cavitation in Biomedicine

View full text Add to dashboard Cite

Section: Magnetic Resonance Cavitation Imagingmentioning

confidence: 99%

Cavitation Imaging in Tissues

Zhong

Chen

et al. 2015

Cavitation in Biomedicine

View full text Add to dashboard Cite

“…The bioeffects harnessed to ablate the target tissue vary, with their individual dominance depending on the temporal focal intensity and pulsing scheme. For instance, using a continuous wave at an intensity of less than 1 kW/cm 2 , localized thermal ablation of target tissues occurs, arising from accumulated heat in the focal zone and corresponding local temperature elevation of 13 C or more (Clarke and Haar, 1997;Uchida et al, 1998;Blana et al, 2004;Damianou et al, 2004;Orvieto et al, 2009). At higher intensities, destructive effects derive from clouds of micron-sized cavitating bubbles inside the tissue (Xu et al, 2007a;Xu et al, 2007b;Wang et al, 2010), or from transient boiling (in milliseconds) (Canney et al, 2010;Maxwell et al, 2012), depending upon the specific pulsing scheme.…”

Section: Introductionmentioning

confidence: 99%

Dependence of ablative ability of high-intensity focused ultrasound cavitation-based histotripsy on mechanical properties of agar

Bigelow

Davis

et al. 2014

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Cavitation-based histotripsy uses high-intensity focused ultrasound at low duty factor to create bubble clouds inside tissue to liquefy a region, and provides better fidelity to planned lesion coordinates and the ability to perform real-time monitoring. The goal of this study was to identify the most important mechanical properties for predicting lesion dimensions, among these three: Young's modulus, bending strength, and fracture toughness. Lesions were generated inside tissue-mimicking agar, and correlations were examined between the mechanical properties and the lesion dimensions, quantified by lesion volume and by the width and length of the equivalent bubble cluster. Histotripsy was applied to agar samples with varied properties. A cuboid of 4.5mm width (lateral to focal plane) and 6mm depth (along beam axis) was scanned in a raster pattern with respective step sizes of 0.75 and 3mm. The exposure at each treatment location was either 15, 30, or 60s. Results showed that only Young's modulus influenced histotripsy's ablative ability and was significantly correlated with lesion volume and bubble cluster dimensions. The other two properties had negligible effects on lesion formation. Also, exposure time differentially affected the width and depth of the bubble cluster volume. KeywordsMechanical Engineering, algae, bending strength, cavitation, elastic moduli, fracture, polysaccharides, tissue, ultrasonics, bubble clusters, high intensity focused ultrasound, lesion formation, real time monitoring, Young's Modulus, biomechanics Disciplines Electrical and Computer Engineering | Mechanical Engineering CommentsThe following article appeared in Journal of the Acoustical Society of America 136 (2014) Cavitation-based histotripsy uses high-intensity focused ultrasound at low duty factor to create bubble clouds inside tissue to liquefy a region, and provides better fidelity to planned lesion coordinates and the ability to perform real-time monitoring. The goal of this study was to identify the most important mechanical properties for predicting lesion dimensions, among these three: Young's modulus, bending strength, and fracture toughness. Lesions were generated inside tissue-mimicking agar, and correlations were examined between the mechanical properties and the lesion dimensions, quantified by lesion volume and by the width and length of the equivalent bubble cluster. Histotripsy was applied to agar samples with varied properties. A cuboid of 4.5 mm width (lateral to focal plane) and 6 mm depth (along beam axis) was scanned in a raster pattern with respective step sizes of 0.75 and 3 mm. The exposure at each treatment location was either 15, 30, or 60 s. Results showed that only Young's modulus influenced histotripsy's ablative ability and was significantly correlated with lesion volume and bubble cluster dimensions. The other two properties had negligible effects on lesion formation. Also, exposure time differentially affected the width and depth of the bubble cluster volume.

show abstract

“…High-intensity focused ultrasound (HIFU) has been investigated as a therapeutic modality for various medical applications [1][2][3][4]. Ultrasound (US) beams can be focused and transmitted through solid tissue within the body; therefore, the use of an external source of US to destroy non-superficial tumors is feasible.…”

Section: Introductionmentioning

confidence: 99%