High-Intensity Extended Swimming Exercise Reduces Pain-Related Behavior in Mice: Involvement of Endogenous Opioids and the Serotonergic System

Mazzardo-Martins, Leidiane; Martins, Daniel Fernandes; Marcon, Rodrigo; Santos, Ubirajara Duarte dos; Speckhann, Breno; Gadotti, Vinícius M.; Sigwalt, André Roberto; Guglielmo, Luiz Guilherme Antonacci; Santos, Adair Roberto Soares

doi:10.1016/j.jpain.2010.03.015

Cited by 74 publications

(58 citation statements)

References 57 publications

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“…In uninjured animals there are increases in withdrawal thresholds to noxious stimuli with a single swimming exercise task at either a low intensity or high intensity (4), 3 wk of running wheel activity (28,36,38), or a 12-wk resistance strengthening exercise program (39). In contrast, we show that neither 5 days nor 8 wk of running wheel activity changes withdrawal thresh- .…”

Section: Exercise Effects In Uninjured Animalscontrasting

confidence: 57%

“…In comparison, prior studies show that 5-9 days of swimming at moderate intensity prevented spontaneous behaviors to acute intraperitoneal acetic acid injection (39) and by intraplantar formalin injection (34). It is possible that the acute inflammatory muscle hyperalgesia is more difficult to overcome since it is more robust and longer lasting than the spontaneous pain produced by acetic acid and formalin injections.…”

Section: Exercise Effects In Animal Models Of Painmentioning

confidence: 90%

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Regular physical activity prevents development of chronic pain and activation of central neurons

Sluka

O’Donnell

Danielson

et al. 2013

Journal of Applied Physiology

162

168

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Section: Exercise Effects In Uninjured Animalscontrasting

confidence: 57%

Section: Exercise Effects In Animal Models Of Painmentioning

confidence: 90%

Regular physical activity prevents development of chronic pain and activation of central neurons

Sluka

O’Donnell

Danielson

et al. 2013

Journal of Applied Physiology

162

168

View full text Add to dashboard Cite

show abstract

“…The authors highlight that the analgesic effect was reverted with systemic administration of naloxone. Mazzardo-Martins et al 17 evaluated the use of swimming in mice during 30 minutes for five days, with decrease of the number of abdominal contortion caused by acetic acid. Since there was reversion of the effect with the use of naloxone, chlorophenilalanine and bilateral adrenalectomia, swimming produced hyponociception via opioid and serotoninergic systems.…”

Section: Local Pressure (G) Local Pressure (G) Discussionmentioning

confidence: 99%

Uso do exercício resistido antagonizado por naloxone como fator de analgesia em sinovite aguda de joelho de ratos Wistar

Bertolini

Rosa

Silva

et al. 2012

Rev Bras Med Esporte

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Analgesia arising from exercising can occur via release of endogenous opioids in the central nervous system and periphery. However, the literature remains controversial about exercise ways and actions in pain. Thus, the aim of this study was to evaluate whether resistance exercise produces changes on the nociception and suffers interference by applying an opioid inhibitor. 18 rats divided into three groups were used: G1 -hyperalgesia on right knee and untreated; G2 -hyperalgesia and treated with jump sin water; G3-hyperalgesia with previous injection of naloxone and subsequent jumps. To produce hyperalgesia,100µl of 5% formalin was injected in the tibio femoral joint space. Pain was assessed using a digital von Frey filament on the right medial tibiofemoral joint. The evaluation periods were: pre-injury (EV1) after 15 minutes (EV2) and 30 minutes (EV3) and one hour (EV4). The applied exercise was jumpingin water and it occurred after EV2. The animal performed 4 sets of 5 jumps, with an interval of 3 minutes and overload of 50% of body weight. In G1, nociceptive increase was observed, with significant decrease and return to initial baseline values in AV4; G2 showed threshold restoration after exercise and return to baseline; G3 reduced thresholds, without restoration or significant increase in them. We concluded that there was analgesia withuse of exercise and that it was altered by blocking beta-endorphin.

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“…Several physiological mechanisms have been suggested to explain the beneficial effects of imipramine and physical exercise on anxiety [40,45]. Although, it has been shown that imipramine and physical exercise can regulate signal transduction pathways in several regions of the brain and alter the function of several neurotransmitter systems [46], recent neurochemical and behavioral data concerning a neuroprotective role for imipramine and physical exercise [47], its primary effects on anxiety and memory in general are debatable. Animal studies also suggest that imipramine may improve memory deficits induced by environmental stressors or neuropathological insult, but whether imipramine is effective in altering learning combined with physical exercise is unknown.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Imipramine Combined With Swimming Exercise on Memory in Mice

Lm¹

2012

iosrphr

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Abstract--The aim of this study was to investigate in mice the possible effects of imipramine treatment and/or swimming exercise in the animal's models of anxiety and memory. The results suggest that imipramine treatment and/or swimming exercise induces an anxiolytic-like effect in mice in the elevated plus-maze and open-field tests. In addition, comparison within each group during the five days of Morris water maze test, showed a decrease of latency time us groups imipramine from the second day the testing, with increased in exploration ratio in both short and long-term object recognition memory. However, the mice previously exposed to swimming exercise did not differ from saline controls in the memory tests. The results provide evidence that swimming exercise prevents the increased in learning and memory improvement induced by imipramine treatment, while not influencing their anxiotytic effects; a fact that should be relevant to a better understanding of the combination of behavioral and pharmacological therapy.

show abstract

High-Intensity Extended Swimming Exercise Reduces Pain-Related Behavior in Mice: Involvement of Endogenous Opioids and the Serotonergic System

Cited by 74 publications

References 57 publications

Regular physical activity prevents development of chronic pain and activation of central neurons

Regular physical activity prevents development of chronic pain and activation of central neurons

Uso do exercício resistido antagonizado por naloxone como fator de analgesia em sinovite aguda de joelho de ratos Wistar

Effects of Chronic Imipramine Combined With Swimming Exercise on Memory in Mice

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