High-intensity exercise offers no additional benefit to moderate-intensity exercise in reducing liver fat in patients with non-alcoholic fatty liver disease

Cuthbertson, Daniel J.; Sprung, Victoria S.

doi:10.1136/ebmed-2016-110579

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…S1). There were no signi cant difference in basic anthropometric data among three groups (Table S1); after 6 month exercise training, main clinical characteristics changed (Table S2), particularly, IHTG content were signi cant decreased (by 5.0% in the vigorous exercise, P < 0.001; 4.2% in the moderate exercise, P < 0.001), but high-intensity exercise offered no additional bene t to moderate intensity exercise in decreasing IHTG (P = 0.45) 5,10 .…”

Section: Subjects Characteristicsmentioning

confidence: 99%

Dimethylguanidino valeric acid is independently associated with intrahepatic triglyceride content in patients with nonalcoholic fatty liver disease (NAFLD) and decreased after long-term exercise

Huang²,

Huang

et al. 2020

Preprint

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Backgrounds: Dimethylguanidino valeric acid (DMGV) is closely associated with nonalcoholic fatty liver disease (NAFLD), the most recommended therapy of NAFLD is Exercise. Our aim was to investigate the correlation between DMGV concentrations and clinical characters in patients with NAFLD, and assessed the effect on DMGV concentrations changes after 6 month exercise training.Methods: NAFLD individuals (n = 220) were selected and randomly divided into control group (n = 74), moderate exercise group (n = 73) and vigorous exercise group (n = 73) with 6 month followed-up. Clinical characteristics were obtained from our previous clinical trial, serum DMGV levels were determined by a validated ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method.Results: On baseline, DMGV levels were positive associated with age, visceral fat and intrahepatic triglyceride (IHTG) content, and inversely associated with fasting blood glucose and diastolic blood pressure. In addition, the association between DMGV levels and IHTG content remained significant after adjusting other main clinical characters (β coefficient = 0.174, P = 0.018). After 6 month exercise training, IHTG was decreased by both exercise intensities without a significant difference (P = 0.45), however, moderate exercise was more efficient on DMGV decreasing than vigorous exercise (-9.96 to 2.27 ng/ml, P < 0.001 for moderate exercise; -4.53 to 4.56 ng/ml, P = 0.762 for vigorous exercise) with a significant difference (P = 0.047).Conclusions: DMGV was a potential indicator during development and progression of NAFLD, and moderate exercise was more efficient on metabolic changes than vigorous exercise with equal IHTG improvement, suggesting a priority of exercise intensity during NAFLD treatment.ClinicalTrials.gov Identifier: NCT01418027, August 16, 2011

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Section: Subjects Characteristicsmentioning

confidence: 99%

Dimethylguanidino valeric acid is independently associated with intrahepatic triglyceride content in patients with nonalcoholic fatty liver disease (NAFLD) and decreased after long-term exercise

Huang²,

Huang

et al. 2020

Preprint

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“…Various exercise intensities impacted plasma metabolic pro le differently [15][16][17], for now, there were fewer studies that examined the circulating AAs alteration after exercise training [18][19][20][21][22], and the relationship between AAs metabolism and exercise intensity was little known. Our previous clinic trial demonstrated that intrahepatic triglyceride (IHTG) content in NAFLD patients were decreased signi cantly by both 6 month vigorous and moderate exercise training, and high intensity exercise offers no additional bene t to moderate intensity exercise in reducing liver fat [4,23], although vigorous exercise was more effective on weight, waist circumference, body fat and visceral fat. However, the metabolic pro le of plasma AAs in these NAFLD subjects were unknown, and whether AAs concentrations altered after different exercise intensity training were still unclear [24].…”

Section: Introductionmentioning

confidence: 99%

Moderate, Rather Than Vigorous Exercise Benefits Plasma Amino Acids Profile in Patients With Nonalcoholic Fatty Liver Disease

Li¹,

Shi²,

Huang³

et al. 2020

Preprint

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Backgrounds: Exercise benefits nonalcoholic fatty liver disease (NAFLD), and amino acids (AAs) are close associated with the development and progression of NAFLD. However, it is unclear whether AAs profile changes following long term exercise training.Methods: NAFLD participants (n=220) were recruited and randomly assigned to control group, moderate exercise group, and vigorous exercise group with a 6-month followed-up. Clinical characteristics were carefully calculated and plasma AAs concentrations were determined using a validated ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method. Results: At baseline, AAs concentrations were close associated with clinical characteristics in NAFLD, particularly, the sum of branched chain amino acids (BCAAs) were positively associated with intrahepatic triglyceride (IHTG) content (r=0.18, P=0.007). After 6 month exercise intervention, IHTG content was reduced by both exercise intensities without a significant difference (P=0.45). Compared to control, several AAs concentrations altered, and different exercise intensity showed inversely impact on histidine, serine, glutamine, valine, tyrosine and tryptophan concentrations changes, particularly, moderate exercise was much more efficient on BCAAs decreasing than vigorous exercise with a significant difference (P=0.0008). Conclusions: Several AAs were close associated with IHTG content in NAFLD patients, and 6 month moderate exercise was more efficient on AAs concentrations alteration, especially BCAAs decreasing than vigorous exercise. Trial registration number: NCT01418027

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High-intensity exercise offers no additional benefit to moderate-intensity exercise in reducing liver fat in patients with non-alcoholic fatty liver disease

Cited by 2 publications

References 3 publications

Dimethylguanidino valeric acid is independently associated with intrahepatic triglyceride content in patients with nonalcoholic fatty liver disease (NAFLD) and decreased after long-term exercise

Dimethylguanidino valeric acid is independently associated with intrahepatic triglyceride content in patients with nonalcoholic fatty liver disease (NAFLD) and decreased after long-term exercise

Moderate, Rather Than Vigorous Exercise Benefits Plasma Amino Acids Profile in Patients With Nonalcoholic Fatty Liver Disease

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