High intensity aerobic exercise does not prime the brain for anodal transcranial direct current stimulation

Hendy, Ashlee M.; Macpherson, Helen; Nuzum, Nathan D.; Gatta, Paul A. Della; Alexander, Sarah E.; Hoy, Kate Elizabeth; Enticott, Peter G.; Teo, Wei‐Peng

doi:10.1016/j.brs.2019.04.007

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…Although the non-significant effects of a-tDCS and highintensity interval exercise on motor learning were unexpected in the current study, it is notable that two recent studies investigating the combination of a-tDCS and aerobic exercise on executive functions also reported no significant benefit on cognitive performance (Hendy et al, 2019;Thomas et al, 2020). While these studies had differences in protocol, including difference in cognitive tasks and stimulated regions, making them not directly comparable, these non-significant findings also reflect the ongoing difficulty in replicability of results using tDCS (Horvath et al, 2014), and to a more limited extent, aerobic exercise (Mellow et al, 2020).…”

Section: Discussioncontrasting

confidence: 76%

“…While these studies had differences in protocol, including difference in cognitive tasks and stimulated regions, making them not directly comparable, these non-significant findings also reflect the ongoing difficulty in replicability of results using tDCS ( Horvath et al, 2014 ), and to a more limited extent, aerobic exercise ( Mellow et al, 2020 ). Individual differences in the response to tDCS have been observed ( Filmer et al, 2019 ), and it may be that exercise induces individualized responses too ( Hendy et al, 2019 ). These differences have been shown to include response modulation from base levels of gamma-aminobutyric acid and glutamate, known to relate to neurochemical excitability ( Filmer et al, 2019 ), and the direction of response achieved (excitatory or inhibitory) ( Wiethoff et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

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A Short-Term Intervention of High-Intensity Exercise and Anodal-tDCS on Motor Learning in Middle-Aged Adults: An RCT

Quinlan

Rattray

Pryor

et al. 2021

Front. Hum. Neurosci.

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High-intensity exercise has enhanced motor learning in healthy young adults. Anodal-transcranial direct current stimulation (a-tDCS) may optimize these effects. This study aimed to determine the effects of a short-term high-intensity interval exercise intervention either with or without a-tDCS on the learning and retention of a novel motor task in middle-aged adults. Forty-two healthy middle-aged adults (age = 44.6 ± 6.3, female = 76%) were randomized into three groups: exercise and active a-tDCS, exercise and sham a-tDCS, and a non-exercise and sham a-tDCS control. Participants completed a baseline testing session, followed by three intervention sessions 48-h apart. The exercise groups completed 20-min of high-intensity exercise followed by a novel sequential visual isometric pinch task (SVIPT) while receiving 20-min of 1.5 mA a-tDCS, or sham tDCS. The control group completed 20-min of reading before receiving sham a-tDCS during the SVIPT. Learning was assessed by skill change within and between intervention sessions. Participants returned 5–7 days after the final intervention session and performed the SVIPT task to assess retention. All three groups showed evidence of learning on the SVIPT task. Neither group displayed enhanced overall learning or retention when compared to the control group. High-intensity exercise with or without a-tDCS did not improve learning or retention of a novel motor task in middle-aged adults. The methodological framework provides direction for future research to investigate the potential of differing exercise intensity effects on learning and retention.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

A Short-Term Intervention of High-Intensity Exercise and Anodal-tDCS on Motor Learning in Middle-Aged Adults: An RCT

Quinlan

Rattray

Pryor

et al. 2021

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Here, we used a design where exercise preceded tDCS, which was presented while participants performed cognitive tasks. Alternatively, both tDCS could have been administered during the treadmill activity or simultaneous exercise and neurostimulation, or tDCS could have preceded the exercise activity [93]. Both alternatives are worthy of additional investigation to gain a deeper understanding of the interactive effects of each enhancement technique.…”

Section: Future Directionsmentioning

confidence: 99%

Combined and Isolated Effects of Acute Exercise and Brain Stimulation on Executive Function in Healthy Young Adults

Hussey

Fontes

Ward

et al. 2020

JCM

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Acute cognitive enhancement has been sought by healthy young individuals to improve academic and professional performance. Among several methods, physical exercise interventions and transcranial direct current brain stimulation (tDCS) have shown promise in impacting executive functions. Here, we observed a set of new findings about the causal effect of acute aerobic exercise and tDCS across three facets of executive function: Inhibition (as measured by a flanker task) was selectively impacted by acute aerobic exercise but not tDCS, whereas working memory (as measured by an n-back task) was impacted by both acute aerobic exercise and tDCS, with effects emerging on distinct processing components for each manipulation. Sustained attention (as measured by the Mackworth clock task), on the other hand, was not impacted by acute aerobic exercise or tDCS. Interestingly, no effects of combining acute aerobic exercise and tDCS emerged. We argue that understanding the unique and combined contributions of these cognitive enhancement techniques can not only contribute to a deeper mechanistic explanation in healthy individuals but also inform future research with clinical and aging populations.

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Effects of high-intensity interval training combined with dual-site transcranial direct current stimulation on inhibitory control and working memory in healthy adults

Yue,

Liu,

Nitsche

et al. 2024

Human Movement Science

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High intensity aerobic exercise does not prime the brain for anodal transcranial direct current stimulation

Cited by 6 publications

References 9 publications

A Short-Term Intervention of High-Intensity Exercise and Anodal-tDCS on Motor Learning in Middle-Aged Adults: An RCT

A Short-Term Intervention of High-Intensity Exercise and Anodal-tDCS on Motor Learning in Middle-Aged Adults: An RCT

Combined and Isolated Effects of Acute Exercise and Brain Stimulation on Executive Function in Healthy Young Adults

Effects of high-intensity interval training combined with dual-site transcranial direct current stimulation on inhibitory control and working memory in healthy adults

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