High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: No role for serum level of homocysteine

Haghdoost-Yazdi, Hashem; Fraidouni, Negin; Faraji, Ayda; Jahanihashemi, Hassan; Sarookhani, Mohammad Reza

doi:10.1016/j.bbr.2012.05.011

Cited by 22 publications

(25 citation statements)

References 57 publications

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“…Thus, a reduced prevalence of this enterotype would be in line with decreased levels of these vitamins in PD patients . Supplementation of these vitamins and short chain fatty acids may have therapeutic potential in PD . Decreased Prevotellaceae abundance also fits well with observations of increased gut permeability in PD because low Prevotella levels may indicate decreased mucin synthesis, which is associated with increased gut permeability .…”

Section: Discussionsupporting

confidence: 57%

Gut microbiota are related to Parkinson's disease and clinical phenotype

et al. 2014

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In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently affected by alpha-synuclein pathology. Accordingly, gastrointestinal dysfunction, in particular constipation, is an important non-motor symptom in PD and often precedes the onset of motor symptoms by years. Recent research has shown that intestinal microbiota interact with the autonomic and central nervous system via diverse pathways including the ENS and vagal nerve. The gut microbiome in PD has not been previously investigated. We compared the fecal microbiomes of 72 PD patients and 72 control subjects by pyrosequencing the V1-V3 regions of the bacterial 16S ribosomal RNA gene. Associations between clinical parameters and microbiota were analyzed using generalized linear models, taking into account potential confounders. On average, the abundance of Prevotellaceae in feces of PD patients was reduced by 77.6% as compared with controls. Relative abundance of Prevotellaceae of 6.5% or less had 86.1% sensitivity and 38.9% specificity for PD. A logistic regression classifier based on the abundance of four bacterial families and the severity of constipation identified PD patients with 66.7% sensitivity and 90.3% specificity. The relative abundance of Enterobacteriaceae was positively associated with the severity of postural instability and gait difficulty. These findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype. Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and PD and the suitability of the microbiome as a biomarker.

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Section: Discussionsupporting

confidence: 57%

Gut microbiota are related to Parkinson's disease and clinical phenotype

et al. 2014

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“…High folic acid concentrations have been found with tomato and mixture extracts, up to 1.5 and 1.3 µg mL -1 , respectively. In tomato extract, high intake of folic acid increases plasma Hcy, which is completely correlated with Haghdoost-Yazdi et al [23]; while Chmurzynska [12] found that mean serum Hcy levels for the dietary groups ranged from 5.6-7.6 nmoL mL -1 . with hemolytic anemia, who may have episodes when excessive red blood cell destruction takes place, increasing bilirubin levels.…”

Section: Resultsmentioning

confidence: 70%

Hypo-Homocysteinemia Effect for Some Ethanolic Plant Extracts

Shaker¹,

Manaa²,

Mubarak³

et al. 2013

J Nutr Food Sci

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Recently, elevated plasma homocysteine (Hcy) levels have been impilicated as a risk factor for atherosclerosis, resulting in coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Elevation of plasma homocysteine has been gradually induced subcutenous s.c. for male albino rats, beginning from the 5 th day, and up to three weeks. Oxidative stress is known as one of the mechanisms in injury for Hcy induction. Fruits and vegetables have been proved in lowering the Hcy effects. Fourty two male rats were divided individually into 7 groups as followed: control, Hcy group, Hcy administration with avocado, broccoli, lettuce, tomato and mixture ethanolic extracts (50 gm 100 ml -1 ).Hcy gradually administrated for groups 2-7 (0.3, 0.4, and 0.6 µmoL g -1 body weight), beginning from 5 th day for one week, second and third week, respectively. In the first two weeks, groups 3-7 were fed on basal diet with 0.1 ml oral inj. (per rat weighted 150 gm) avocado, broccoli, lettuce, tomato and mixture extracts.HPLC results showed remarkable Hcy concentrations with avocado, mixture and lettuce extracts; 1.8 and 2.8 and 2.9 µg mL -1 , respectively. By the end of the experiment, mixture and broccoli significant decreased total billirubin (0.42 mg dL -1 35%, 0.44 mg dL -1 32%, respectively), and GPT (29.55,29.63 units mL -1 , respectively). LDL/HDL or risk factor has been declined significantly with broccoli extract (91%-0.04 mg dL -1 ). Creatinine (0.29 mg dL -1 , 50%) and urea (29.63 mg dL -1 , 29%) showed significant improvement with tomato extract comparing to infected group. Avocado showed significant antioxidative activity or reduction in MDA (7.13 nmol mL -1 , 50%).

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“…Previously, authors reported that B com has neuroprotective effect against 6-OHDA-induced neurotoxicity (24). Also, biochemical analysis showed that neuroprotective effect of B com was not mediated by lowering plasma homocysteine.…”

Section: Discussionmentioning

confidence: 97%

“…Additional B vitamins were dissolved in drinking water as described before (24). Ethanol, Glib and flu were daily administrated, intraperitoneally.…”

Section: Animals and Experimental Groupsmentioning

confidence: 99%

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Synergistic Antiparkinsonian Effect of Flunarizine, Glibenclamide and B Vitamins in a Rat 6-Hydroxydopamine Model; The Role of Malondialdehyde

Sarookhani¹,

Haghdoost-Yazdi²,

Piri³

et al. 2016

Biotech Health Sci

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Background: The current study evaluated the effects of a combination of flunarizine (flu) a calcium channel blocker, glibenclamide (Glib), a KATP channels blocker and B vitamins (B com) on the behavioral symptoms of 6-hydroxydopamine (6-OHDA)-induced model of Parkinson disease to examine the synergistic antiparkinsonian effects of the drugs and supplements. Also the level of malondialdehyde (MDA) was measured in blood and brain suspensions to find probable neuroprotective mechanism of these materials.

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High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: No role for serum level of homocysteine

Cited by 22 publications

References 57 publications

Gut microbiota are related to Parkinson's disease and clinical phenotype

Gut microbiota are related to Parkinson's disease and clinical phenotype

Hypo-Homocysteinemia Effect for Some Ethanolic Plant Extracts

Synergistic Antiparkinsonian Effect of Flunarizine, Glibenclamide and B Vitamins in a Rat 6-Hydroxydopamine Model; The Role of Malondialdehyde

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