High Inflammatory Burden: A Potential Cause of Myocardial Injury in Critically Ill Patients With COVID-19

Song, Yanjun; Gao, Peng; Tian, Rong; Qian, Hai; Guo, Fan; Chang, Long; Wu, Wei; Zhang, Shuyang

doi:10.3389/fcvm.2020.00128

Cited by 24 publications

(27 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, a high systemic inflammatory burden was demonstrated to be positively associated with myocardial injury in critically ill patients with COVID-19. 22 In this study, anti-inflammation therapies such as glucocorticoids or tocilizumab were used in some patients, and we found that inflammatory cytokine levels were decreased. However, related clinical investigations were not performed in this study.…”

Section: Discussionmentioning

confidence: 68%

Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: A Retrospective in-ICU Study

Qian

Gao

Tian

et al. 2021

Journal of Cardiothoracic and Vascular Anesthesia

Self Cite

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 68%

Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: A Retrospective in-ICU Study

Qian

Gao

Tian

et al. 2021

Journal of Cardiothoracic and Vascular Anesthesia

Self Cite

View full text Add to dashboard Cite

show abstract

“…There have been plenty of studies indicating that serum levels of cytokines are significantly increased in COVID-19 patients ( 3 , 4 ). Moreover, cytokine levels were associated with disease mortality and the incidence of myocardial injury ( 2 , 25 , 26 ), indicating the contributing role of cytokine storm in COVID-19 associated myocardial injury. In our population, compared with patients without myocardial injury, IL-6 levels were significantly higher in myocardial injury patients, implying the possible pathogenic role of the cytokine storm in the development of myocardial injury.…”

Section: Discussionmentioning

confidence: 99%

Pre-existing Health Conditions and Epicardial Adipose Tissue Volume: Potential Risk Factors for Myocardial Injury in COVID-19 Patients

Wei

Chen

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Myocardial injury is a life-threatening complication of coronavirus disease 2019 (COVID-19). Pre-existing health conditions and early morphological alterations may precipitate cardiac injury and dysfunction after contracting the virus. The current study aimed at assessing potential risk factors for COVID-19 cardiac complications in patients with pre-existing conditions and imaging predictors.Methods and Results: The multi-center, retrospective cohort study consecutively enrolled 400 patients with lab-confirmed COVID-19 in six Chinese hospitals remote to the Wuhan epicenter. Patients were diagnosed with or without the complication of myocardial injury by history and cardiac biomarker Troponin I/T (TnI/T) elevation above the 99th percentile upper reference limit. The majority of COVID-19 patients with myocardial injury exhibited pre-existing health conditions, such as hypertension, diabetes, hypercholesterolemia, and coronary disease. They had increased levels of the inflammatory cytokine interleukin-6 and more in-hospital adverse events (admission to an intensive care unit, invasive mechanical ventilation, or death). Chest CT scan on admission demonstrated that COVID-19 patients with myocardial injury had higher epicardial adipose tissue volume ([EATV] 139.1 (83.8–195.9) vs. 92.6 (76.2–134.4) cm2; P = 0.036). The optimal EATV cut-off value (137.1 cm2) served as a useful factor for assessing myocardial injury, which yielded sensitivity and specificity of 55.0% (95%CI, 32.0–76.2%) and 77.4% (95%CI, 71.6–82.3%) in adverse cardiac events, respectively. Multivariate logistic regression analysis showed that EATV over 137.1 cm2 was a strong independent predictor for myocardial injury in patients with COVID-19 [OR 3.058, (95%CI, 1.032–9.063); P = 0.044].Conclusions: Augmented EATV on admission chest CT scan, together with the pre-existing health conditions (hypertension, diabetes, and hyperlipidemia) and inflammatory cytokine production, is associated with increased myocardial injury and mortality in COVID-19 patients. Assessment of pre-existing conditions and chest CT scan EATV on admission may provide a threshold point potentially useful for predicting cardiovascular complications of COVID-19.

show abstract

“…10 SARS-CoV-2 infection mainly affects the respiratory tract 11 but recently has been associated with significant multiple organ dysfunction syndrome. 12 One of the most common critical complications during COVID-19 is myocardial injury, 13,14 especially in patients with a higher inflammatory profile. 13 As the pandemic is still ongoing, it is impossible to precise the impact of SARS-CoV-2 infection in the overall population, but to the moment, COVID-19 has caused almost 1 million deaths worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…12 One of the most common critical complications during COVID-19 is myocardial injury, 13,14 especially in patients with a higher inflammatory profile. 13 As the pandemic is still ongoing, it is impossible to precise the impact of SARS-CoV-2 infection in the overall population, but to the moment, COVID-19 has caused almost 1 million deaths worldwide. Although CD affects millions, to the moment, there is no report of CD and COVID-19 coinfection in the literature.…”

Section: Introductionmentioning

confidence: 99%

Case Report: COVID-19 and Chagas Disease in Two Coinfected Patients

Alberca

Yendo

Ramos

et al. 2020

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

American trypanosomiasis, also named Chagas disease (CD), is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi. The disease affects millions of people worldwide, leading yearly to approximately 50,000 deaths. COVID-19, generated by SARS-CoV-2, can lead to lymphopenia and death. We hereby describe the first report of two patients with CD and COVID-19 coinfection, from hospitalization until patients' death.

show abstract

High Inflammatory Burden: A Potential Cause of Myocardial Injury in Critically Ill Patients With COVID-19

Cited by 24 publications

References 43 publications

Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: A Retrospective in-ICU Study

Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: A Retrospective in-ICU Study

Pre-existing Health Conditions and Epicardial Adipose Tissue Volume: Potential Risk Factors for Myocardial Injury in COVID-19 Patients

Case Report: COVID-19 and Chagas Disease in Two Coinfected Patients

Contact Info

Product

Resources

About