High infiltration of tumor‐associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer

Sugimura, Keijiro; Miyata, Hiroshi; Tanaka, Koji; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Yamasaki, Makoto; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro

doi:10.1002/jso.23881

Cited by 116 publications

(90 citation statements)

References 39 publications

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“…Thirteen articles evaluated patients’ OS [11, 12, 24, 28, 30-33, 35, 37-40]. The pooled results showed that patients with high level of CD8 + TILs had better OS (pooled HR = 0.68; 95% CI = 0.56-0.84; P < 0.001) (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Zheng¹,

Song

Shao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Several studies have verified the correlation between tumor-infiltrating lymphocytes (TILs) and survival of patients with esophagus cancer (EC). However, the prognostic role of TILs is still controversial. Therefore, we performed this meta-analysis. Methods: We searched PubMed, Embase and the Cochrane Library (last update by August 30, 2017) to identify studies assessing the effect of TILs on survival of patients with EC. Pooled hazard ratios (HRs) for overall survival (OS), disease-free survival (DFS) and cancer specific survival (CSS) were estimated using fixed-effects models or random-effects models, which depends on the heterogeneity. Results: Data from 22 observational studies including 2909 patients were summarized. Pooled analysis indicated that generalized TILs were favorable prognostic markers for OS in patients with EC (pooled HR = 0.48; 95% CI = 0.38-0.61; P < 0.001). For TIL subsets, CD8⁺ TILs were associated with improved OS (pooled HR = 0.68; 95% CI = 0.58–0.84; P < 0.001) and DFS (pooled HR = 0.90; 95% CI = 0.85-0.95; P < 0.001); FoxP3⁺ TILs were associated with patients’ DFS (pooled HR = 0.88; 95% CI = 0.81-0.96; P = 0.003). High CD57⁺ TILs indicated a better OS in patients with EC (pooled HR = 0.50; 95% CI = 0.35-0.72; P < 0.001). In addition, the pooled results showed that other TIL subsets including CD3⁺, CD4⁺ and CD45RO⁺ TILs were not associated with patients’ survival (P > 0.05). Conclusions: For patients with EC, some TIL subsets could serve as prognostic biomarkers. The application of TILs in the immunotherapy of EC needs to be verified through a large amount of clinical research.

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Section: Resultsmentioning

confidence: 99%

“…A total of 16 articles, including 2121 patients, investigated the prognostic value of CD8 + TILs in patients with EC [11-14, 24, 25, 28, 30-33, 35, 37-40]. Thirteen articles evaluated patients’ OS [11, 12, 24, 28, 30-33, 35, 37-40].…”

Section: Resultsmentioning

confidence: 99%

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Zheng¹,

Song

Shao

et al. 2018

Cell Physiol Biochem

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“…The initiation and progression of esophageal cancer is a complicated process that results from the loss of the normal regulatory pathways controlling cell proliferation, differentiation and apoptosis. However, present therapeutic strategies, including chemotherapy, are characterized by low efficacies (4). Drug resistance and side effects of chemotherapy drugs are major barriers to the success of chemotherapy (5).…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells

2017

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Abstract. Epigallocatechin-3-gallate (EGCG) is a component of green tea with anticancer effects that have been demonstrated in multiple types of cancer, but few reports exist concerning its effect in esophageal squamous cell carcinoma cells. The present study investigated apoptosis induced by EGCG treatment and the underlying molecular mechanisms in Eca109 and Ec9706 human esophageal squamous cell carcinoma cells. The apoptosis rate following treatment with various concentration of EGCG for 24 h was detected by flow cytometry. The effect of EGCG on esophageal cancer cell viability was detected via MTT assay. Mitochondrial membrane potential and caspase-3 protein expression was detected in Eca109 and Ec9706 cells following treatment with EGCG by flow cytometry. The telomerase activity of Eca109 and Ec9706 cells following treatment with EGCG was assayed using the polymerase chain reaction-telomeric repeat amplification protocol (PCR-TRAP) argentation method. EGCG was demonstrated to inhibit the viability of Eca109 and Ec9706 cells in a dose-and time-dependent manner. The flow cytometry results revealed that EGCG treatment induced apoptosis, decreased the mitochondrial membrane potential and increased caspase-3 protein expression levels. PCR-TRAP argentation analysis revealed that EGCG inhibited telomerase activity. The results of the present study suggested that EGCG functions as an antitumor agent in esophageal cancer cells. The induction of apoptosis may be a viable method for treating esophageal cancer. It is possible to induce apoptosis by modulating the expression level of telomerase activity, mitochondrial membrane potential and caspase-3 protein expression levels.

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“…Tumor-associated macrophages are associated with the EC response to chemotherapy [3]. Sugimura et al [3] have found that filtration of CD68(+) macrophages and CD163(+) macrophages was significantly associated with tumor depth, lymphatic invasion and venous invasion of EC.…”

mentioning

confidence: 99%

“…Sugimura et al [3] have found that filtration of CD68(+) macrophages and CD163(+) macrophages was significantly associated with tumor depth, lymphatic invasion and venous invasion of EC. High infiltration of CD68(+) macrophages and CD163(+) macrophages was significantly associated with poor response to chemotherapy for EC patients undergoing neoadjuvant chemotherapy.…”

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confidence: 99%

Prognostic markers in esophageal cancer: from basic research to clinical use

Hong¹,

Han²,

Zhang³

et al. 2015

Expert Review of Gastroenterology & Hepatology

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High infiltration of tumor‐associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer

Abstract: Infiltration of TAMs, especially M2 macrophages, is associated with a poor response to chemotherapy and poor prognosis of patients with esophageal cancer.

Cited by 116 publications

References 39 publications

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells

Prognostic markers in esophageal cancer: from basic research to clinical use

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