High Incidence of Internal Malignancy in Papuloerythroderma of Ofuji: A Case Series from Japan

Abstract

Background: Although it has been reported that papuloerythroderma of Ofuji (PEO) often occurs in association with internal malignancy, the true incidence of malignancy in patients with PEO is unknown. Objective and Methods: To ascertain the incidence of and relationship with internal malignancy in patients with PEO, 11 patients with PEO diagnosed at our dermatology clinic between September 2005 and June 2011 were retrospectively reviewed. Results: Internal malignancy was found in 6 (54.5%) of the 11 PEO patients, and 5 cases were idiopathic PEO. In the 6 cases with associated malignancy, PEO preceded the malignancies, and the diagnosis of malignancy was made just before or shortly after the diagnosis of PEO, but the malignant process and PEO did not always run a parallel course. Conclusions: Although the limitations of this study included a relatively small sample size, the present findings show a high incidence of internal malignancy in patients with PEO.

Skin-Homing Th2/Th22 Cells in Papuloerythroderma of Ofuji

“…PEO is characterized by pruritic, erythroderma-like lesions formed by the coalescence of solid, red to brown papules with sparing of the skin folds (the so-called deck-chair sign) [1,2,3]. This condition primarily occurs in elderly men and its course is chronic.…”

“…This condition primarily occurs in elderly men and its course is chronic. PEO may be associated with underlying conditions such as malignancy [2,3], infection [2] and drug ingestion [4]; however, its pathogenesis remains unclear. Peripheral blood eosinophilia and increased serum IgE levels are observed in most patients with PEO [2,3].…”

“…PEO may be associated with underlying conditions such as malignancy [2,3], infection [2] and drug ingestion [4]; however, its pathogenesis remains unclear. Peripheral blood eosinophilia and increased serum IgE levels are observed in most patients with PEO [2,3]. The histopathology of PEO skin lesions exhibits epidermal acanthosis, occasional spongiosis and inflammatory dermal infiltrates primarily composed of lymphocytes and eosinophils.…”

Papuloerythroderma of Ofuji: clinical case

“…Одновременно наблюдаются дискретные папулы на сгибательных поверхностях конечностей и вокруг эритродермических участков. Возможен зуд, невыраженная полиаденопатия [1,18,19].…”

“…Злокачественный тип ПО с признаками Т-клеточных лимфом выявляется уже при первом обращении за медицинской помощью либо он раз-вивается после различного по длительности периода трансформации [13,17,18].…”