High Incidence of Familial Gastric Cancer in Tuscany, a Region in Italy

Roviello, Franco; Corso, Giovanni; Pedrazzani, Corrado; Marrelli, Daniele; Falco, Giulia De; Suriano, Gianpaolo; Vindigni, Carla; Berardi, Anna; Garosi, Lorenzo; Stefano, Alfonso De; Leoncini, Lorenzo; Seruca, Raquel; Pinto, Enrico

doi:10.1159/000113015

Cited by 23 publications

(22 citation statements)

References 53 publications

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“…20 It is well known that the prevalence of H. pylori infection in the general population is higher in countries with a higher incidence of gastric cancer 21 ; in Tuscany, the incidence of gastric cancer is very high compared with other regions of Italy. 22 Epidemiologic factors and the sensitivity of the methods used could explain the high rates of H. pylori positivity reported in the current series.…”

Section: Discussionmentioning

confidence: 75%

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Marrelli

Pedrazzani

Berardi

et al. 2009

Cancer

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119

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NELL‐1 (Nel‐like molecule‐1) is a secreted osteogenic growth factor first identified in human craniosynostosis (CS) patients. NELL‐1 protein has been observed to promote bone and cartilage differentiation and to suppress adipogenesis in both in vitro and in vivo models. Despite these findings, the cell surface receptors of NELL‐1 have remained unknown. In this study, we observed for the first time that NELL‐1 promotes cell adherence in multiple cell lines, including ST2, C3H10T1/2, M2‐10B4, ATDC5, and MC3T3 cells. Additionally, we found that NELL‐1 binds to extracellular Integrinβ1 and induces cell focal adhesion. By utilizing siRNA methods, we determined that NELL‐1 cell surface binding and enhanced cell attachment were dependent on Integrinβ1 expression. Finally, we observed that pre‐coating of culture dishes or PLGA (polylactic‐co‐glycolic acid) scaffold with NELL‐1 resulted in a significant increase in both cell attachment and osteogenic differentiation. Our results identify for the first time a cell surface target of NELL‐1, Integrinβ1, and elucidate new functions of NELL‐1 in promoting cell adherence and osteogenic differentiation. J. Cell. Biochem. 113: 3620–3628, 2012. © 2012 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 75%

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Marrelli

Pedrazzani

Berardi

et al. 2009

Cancer

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119

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“…Japanese studies [4,7] reported that the undifferentiated histological type was dominant in FGC, and there was a predisposition to the intestinal type when both parents suffered from GCs while to the diffuse type when both parents suffered from non-GCs. The dominance of the intestinal type and the diffuse type was reported in Italy and Poland, respectively [13,16,20] . These variations indicate that familial predisposition to GC may be a multifactor disease.…”

Section: Discussionmentioning

confidence: 94%

“…However, the frequency of non-GC in family members differed from the results in other reports. For example, colorectal, lung, and uterine cancers were the highest in ranking in a Japanese report [9] , while colorectal, breast, and lung cancer were prevalent in an Italian report [20] , lung/larynx cancer, gastrointestinal cancer, and leukemia/lymphoma were most frequent in a study from Turkey [18] , and colorectal and lung cancer were most common in a report from Taiwan [6] . In general, the overall ranking of associated non-GCs in family histories of GC varied from region to region, but the preceding tumors were usually the most frequent ones occurring in that general population.…”

Section: Discussionmentioning

confidence: 97%

“…Family history of GC has previously been studied in many regions, including eastern Asian [2][3][4][5][6][7][8][9] , North American [10][11][12] , northern European [13][14][15] , and Mediterranean countries [16][17][18][19][20][21] . A much higher incidence of familial GC (FGC) was reported from Mediterranean countries [19] , while a relatively low occurrence was noted in northern European countries [14] .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of patients by family history with gastric and non-gastric cancer

Zhou¹,

He²,

Song³

et al. 2009

WJG

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AIM:To compare the gastric cancer (GC) patients by their family history with gastric and non-GC. METHODS:Positive family histories within seconddegree relatives and clinicopathological features were obtained for 256 patients. RESULTS:Of the 256 probands, 112 (76 male, 36 female) were incorporated into familial GC (FGC) group: at least two GC members; 144 (98 male, 46 female) were included in the non-FGC group (relatives only affected with non-GCs). Of 399 tumors in relatives (181 from FGC against 212 from non-FGC), GC was the most frequent, followed by esophageal, hepatocellular, and colorectal cancer. Nasopharyngeal cancer was next to lung cancer but prior to breast and urogenital cancers. Most affected members aggregated within first-degree relatives (FGC: 66 siblings, 48 fathers, 31 mothers, four offspring; non-FGC: 56 fathers, 55 siblings, 43 mothers, and 15 offspring). The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a slight risk for GC in males (OR = 1.19, 95% CI: 0.53-2.69), while risk of GC by maternal history of nonGCs was increased in females (OR = 0.46, 95% CI: 0.22-0.97). Diffuse-GC was the major histological type in all subgroups. Difference in tumor sites between the two groups was derived from an excess of upper sites in non-FGC female probands. CONCLUSION:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families, and a certain subtype may be inherited in a female-influenced fashion.

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“…Furthermore, in Tuscany there are some areas, such as the Mugello in the Florence district, with high GC incidence and mortality rates in comparison to the national rates, where previous epidemiological studies have identified many familial groups with a high rate of GC among first-degree relatives [4]. A recent study has also shown a high prevalence of familial hereditary diffuse GC in Tuscany [5]. …”

Section: Introductionmentioning

confidence: 99%

Gastric Cancer Surveillance in a High-Risk Population in Tuscany (Central Italy): Preliminary Results

Filomena¹,

Saieva

Lucchetti³

et al. 2011

Digestion

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Background/Aims: The surveillance of subjects at high risk for developing gastric cancer (GC) may represent an effective strategy for reducing specific morbidity and mortality. The aim of this study was to identify GC at its initial phase and to identify precancerous lesions in a group of GC high-risk subjects. Methods: We enrolled first-degree relatives of patients affected by GC who resided in a GC high-risk area (Tuscany, Central Italy). The study’s protocol included the collection of several individual measurements, including a blood sample for the determination of specific biomarkers, an upper digestive tract endoscopy with detailed gastric biopsies and Helicobacter pylori (Hp) treatment followed by a specific check. Results: We enrolled 167 subjects who were members of 128 different familial groups with GC history. We identified 1 case of initial-phase GC, 1 gastric dysplasia type II, 32 intestinal metaplasia, 10 gastric atrophy, and 21 atrophic chronic gastritis. 81 subjects were Hp-positive and underwent eradication therapy. Conclusion: This study of a GC high-risk Italian population reveals positive results in terms of population compliance, the identification of specific gastric lesions requiring close follow-up and successful therapy for Hp infection. To define future surveillance strategies, a longer follow-up of these patients is necessary.

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High Incidence of Familial Gastric Cancer in Tuscany, a Region in Italy

Cited by 23 publications

References 53 publications

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Comparison of patients by family history with gastric and non-gastric cancer

Gastric Cancer Surveillance in a High-Risk Population in Tuscany (Central Italy): Preliminary Results

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