High incidence of epilepsy related to onchocerciasis in West Uganda

Kaiser, C; Asaba, George; Leichsenring, Michael; Kabagambe, G.

doi:10.1016/s0920-1211(98)00007-2

Cited by 73 publications

(62 citation statements)

References 15 publications

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“…(1) The age distribution of epilepsy prevalence and incidence is very similar between the various onchocerciasis foci where this was investigated, but it is very unusual if compared with other areas in developing as well as industrialized countries. 3,9,19,20 This age distribution would also be consistent with the buildup of onchocerciasis infection in the population.…”

Section: Discussionsupporting

confidence: 73%

Association Between Onchocerciasis and Epilepsy in the Itwara Hyperendemic Focus, West Uganda: Controlling for Time and Intensity of Exposure

Kaiser¹,

Rubaale²,

Tukesiga³

et al. 2011

The American Journal of Tropical Medicine and Hygiene

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Section: Discussionsupporting

confidence: 73%

Association Between Onchocerciasis and Epilepsy in the Itwara Hyperendemic Focus, West Uganda: Controlling for Time and Intensity of Exposure

Kaiser¹,

Rubaale²,

Tukesiga³

et al. 2011

The American Journal of Tropical Medicine and Hygiene

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“…Incidence in Uganda is higher than that reported in Ethiopia (215 new cases per 100,000 population versus 64 new cases per 100,000 populations versus) Tekle-Haimanot, 1997; Kaiser et al, 1998;.…”

Section: Epidemiology Of Epilepsy and Parasitic Infections In Sub-sahmentioning

confidence: 72%

“…In Uganda, Ovuga et al (1992) reported a high prevalence of epilepsy in an area with high transmission of onchorcerciasis. Another study comparing the prevalence of epilepsy in areas with different transmission intensity of onchorcerciasis, observed a high prevalence of epilepsy in hyperendemic areas of onchorcerciasis, as compared to hypoendemic areas (Kaiser et al, 1996;Kaiser et al, 1998). Equally, case-control studies support the existence of a link between onchorcerciasis and epilepsy (Boussinesq, 2002).…”

Section: Onchocerca Volvulus and Onchorcerciasismentioning

confidence: 98%

Epilepsy and tropical parasitic infections in Sub-Saharan Africa: a review

Mazigo

Morona

Kweka

et al. 2013

Tanzania J Hlth Res

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Several reports have suggested that the high prevalence of epilepsy in sub-Saharan Africa is associated with the high prevalence of parasitic infections affecting the central nervous system. Though epidemiological evidence suggests an association between parasitic infections and epilepsy, the biological causal relationship has not been fully demonstrated for many of these infections. The objective of this paper is to review the available epidemiological evidence on the links between parasitic infections and epilepsy, the pathogenesis and the current gap of knowledge indicating the areas requiring further research. Data for this review were identified and collected using manual and electronic search strategies of published and unpublished sources. In Sub-Saharan Africa, the epidemiology of epilepsy remains unclear and given the differing study designs, the results of available epidemiological studies are difficult to interpret and compare. Evidence from surveys reported a median prevalence of 1.5%. Co-infection of parasitic infections and epilepsy in sub-Saharan Africa are common, particularly in areas characterized by poor hygiene standards. There is an epidemiological link on the association between epilepsy and various parasitic infections. However, the biological causal relationship requires further investigation in adequately designed studies. In conclusion, although several epidemiological and case control studies indicate a relationship between parasitic agents and epilepsy in sub-Saharan Africa, there is a considerable gap of knowledge on the cause and magnitude of the association. Thus, there is an urgent need for systematic epidemiological studies to understand the burden of epilepsy in areas endemic due to preventable parasitic infections, to prove a causal relationship, and to understand the impact of controlling these parasitic diseases on reduction of the burden of epilepsy.___________________________________________________________________________________

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“…11 This parish of 4,743 inhabitants is situated in the Itwara onchocerciasis focus, with a prevalence of microfilaria (mf) carriers ranging from 15% to 85% in the 10-20 years age group of its 13 villages in 1994. 11 A detailed description of the epidemiology of onchocerciasis and epilepsy in Kabende parish can be found in our previous publications, [11][12][13][14] and detailed maps of the entire Itwara focus are presented by Garms and others. 15 All patients who were registered in the survey underwent a thorough clinical assessment.…”

Section: Case Reportmentioning

confidence: 99%

Nodding Syndrome, Western Uganda, 1994

Kaiser¹,

Rubaale²,

Tukesiga³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Nodding syndrome (NS) is a poorly understood condition, which was delineated in 2008 as a new epilepsy syndrome. So far, confirmed cases of NS have been observed in three circumscribed African areas: southern Tanzania, southern Sudan, and northern Uganda. Case-control studies have provided evidence of an association between NS and infection with Onchocerca volvulus, but the causation of NS is still not fully clarified. We report a case of a 15-year old boy with head nodding seizures and other characteristic features of NS from an onchocerciasis endemic area in western Uganda, with no contiguity to the hitherto known areas. We suggest that the existence of NS should be systematically investigated in other areas.

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High incidence of epilepsy related to onchocerciasis in West Uganda

Cited by 73 publications

References 15 publications

Association Between Onchocerciasis and Epilepsy in the Itwara Hyperendemic Focus, West Uganda: Controlling for Time and Intensity of Exposure

Association Between Onchocerciasis and Epilepsy in the Itwara Hyperendemic Focus, West Uganda: Controlling for Time and Intensity of Exposure

Epilepsy and tropical parasitic infections in Sub-Saharan Africa: a review

Nodding Syndrome, Western Uganda, 1994

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