High incidence of demodicidosis in eyelid basal cell carcinomas

Erbağcı, Zülal; Erbağcı, İbrahim; Erkılıç, Suna

doi:10.1046/j.1365-4362.2003.01928.x

Cited by 54 publications

(45 citation statements)

References 22 publications

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“…Some studies have suggested a direct, significant correlation between the likelihood of mite infestation and age (29,30). All our patient groups were comparable with the controls in terms of age.…”

Section: Discussionmentioning

confidence: 99%

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Talghini

Fouladi²,

Babaeinejad³

et al. 2015

TurkiyeParazitolDerg

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Objective: To examine the possible associations between Demodex folliculorum and a number of skin diseases. Methods: Standardized skin surface biopsy samples were obtained from the cheeks of 144 patients with histopathologically proven basal cell carcinoma (BCC, n=27), squamous cell carcinoma (SCC, n=28), melanoma (n=23), discoid lupus erythematosus (DLE, n=32), and rosacea (n=34). Thirty-four sex-and age-matched healthy volunteers served as controls. Mite density (per cm 2 ) and infestation (density≥5) were compared between the controls and patients. Results: Mite infestation rates (%) did not differ significantly between the controls (20.6) and patients with BCC (22.2, p=0.88), SCC (17.9, p=0.79), melanoma (4.3, p=0.08), and DLE (21.9, p=0.90). Compared with the controls, the mite infestation rate was significantly higher in patients with rosacea (47.1, p=0.02, odds ratio: 3.43, 95% confidence interval: 1.18-9.99). The mean mite density did not differ significantly between the controls (4.11±2.17) and patients with BCC (5.34±2.35, p=0.75), SCC (3.57±2.01, p=0.38), and DLE (3.56±1.34, p=0.83), whereas it was significantly higher in patients with rosacea (8.78±3.58, p=0.02) and lower in patients with melanoma (1.89±0.69, p=0.02). Conclusions: D. folliculorum may be associated with rosacea and melanoma but not with BCC, SCC, or DLE. Metot: Standardize yüzeyel deri biyopsisi örnekleri; bazal hücreli karsinom (BCC, n=27), skuamöz hücreli karsinom (SCC, n=28), melanom (n=23), diskoid lupus eritematozus (DLE, n=32), ve rozasea (n=34) tanıları histopatolojik olarak kanıtlanmış 144 hastanın yanaklarından alındı. Cinsiyet ve yaşı eşleştirilmiş 34 sağlıklı gönüllü kontrol grubunu oluşturdu. Akar dansitesi (cm 2 başına) ve enfestasyon (dansite≥5) hasta ve kontrol grubu arasında karşılaştırıldı. Bulgular: Akar enfestasyon hızları (%) kontrol grubu (20,6) ile BCC (22,2, p=0,88), SCC (17,9, p=0,79), melanom (4,3, p=0,08), ve DLE (21,9, p=0,90) hastaları arasında anlamlı bir farklılık göstermedi. Kontrol grubuna kıyasla, akar enfestasyon hızı, rozasea olanlarda anlamlı olarak yüksekti (47,1, p=0,02; odds oranı: 3,43, %95 güven aralığı: 1,18-9,99). Ortalama akar dansitesi kontrol grubu (4,11±2,17) ile BCC (5,34±2,35, p=0,75), SCC (3,57±2,01, p=0,38), ve DLE (3,56±1,34, p=0,83) hasta grupları arasında anlamlı bir fark göstermezken, kontrol grubuna kıyasla

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Section: Discussionmentioning

confidence: 99%

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Talghini

Fouladi²,

Babaeinejad³

et al. 2015

TurkiyeParazitolDerg

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“…They have been reported to be involved in pityriasis folliculorum (Ayres, 1930), rosacea (Ayres and Ayres, 1961;Bonnar et al, 1993;Forton and Seys, 1993), pustular folliculitis (Dong and Duncan, 2006), papulopustular scalp eruptions (Purcell et al, 1986), perioral dermatitis (Hsu et al, 2009), and blepharitis (Post and Juhlin, 1963;Divani et al, 2009;Zhao et al, 2012). It is also suspected that Demodex infestation may be one of the triggering factors of carcinogenesis in eyelid basal cell carcinomas (Erbagci et al, 2003) and sebaceous adenoma (Dhingra et al, 2009). Moreover, the infestation rate in the immunocompromised population with leucocythemia (Damian and Rogers, 2003) or acquired immune deficiency syndrome (AIDS) (Clyti et al, 2005) is remarkably high and pustular eruption or seborrheic dermatitis becomes even more conspicuous.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of association between acne vulgaris and Demodex infestation

Zhao

et al. 2012

J. Zhejiang Univ. Sci. B

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Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants including students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34-3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.

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“…The symptoms can disappear under acaricidal therapy, and the skin conditions can heal. Moreover, it is also suspected that Demodex infestation may be one of the triggering factors of carcinogenesis in eyelid basal cell carcinomas (Erbagci et al, 2003) and sebaceous adenoma (Dhingra et al, 2009). The infestation of Demodex has therefore been recognized by many researchers as one of the important causes of skin diseases and has increasingly become a public health concern.…”

Section: Introductionmentioning

confidence: 99%

Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae)

Zhao

Guo

Meng

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:To identify sociodemographic characteristics and risk factor of Demodex infestation, 756 students aged 13-22 years in Xi'an, China were sampled for the school-based cross-sectional study. Demodex was examined using the cellophane tape method (CTP). The results showed that the total detection rate of Demodex was 67.6%. Logistic regression analysis revealed that five variables (gender, residence, sharing sanitary ware, frequency of face-wash per day, and use of facial cleanser) were found to be uncorrelated with Demodex infestation, whereas three variables (age, skin type, and skin disease) were found to be independent correlates. Students aged over 18 years had 22.1 times higher odds of Demodex infestation compared to those under 16 years and students aged 16-18 years also had 2.1 times higher odds compared to those aged 13-15 years. Odds of having a Demodex infestation for oily or mixed skin were 2.1 times those for dry or neutral skin. Students with a facial skin disease had 3.0 times higher odds of being infested with Demodex compared to those without. The inception rate of students with facial dermatoses increased in parallel with increasing mite count. The inception rates were 21.3%, 40.7%, 59.2%, and 67.7% in the negative, mild, moderate, and severe infestation groups, respectively (χ 2 =60.6, P<0.001). Specifically, the amount of infested mites and inception rate of acne vulgaris were positively correlated (R 2 =0.57, moderate infestation odds ratio (OR)=7.1, severe infestation OR=10.3). It was concluded that Demodex prevalence increases with age, and Demodex presents in nearly all adult human. Sebaceous hyperplasia with oily or mixed skin seems to favour Demodex proliferation. Demodex infestation could be associated with acne vulgaris. The CTP is a good sampling method for studies of Demodex prevalence.

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High incidence of demodicidosis in eyelid basal cell carcinomas

Abstract: Demodicidosis may be one of the triggering factors of carcinogenesis in eyelid BCCs in otherwise predisposed people due to its traumatic/irritating effect or chronic inflammation.

Cited by 54 publications

References 22 publications

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

A meta-analysis of association between acne vulgaris and Demodex infestation

Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae)

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