High Incidence of Atypical Forms of Coeliac Disease in a Pediatric Case Study

A simple, rapid, highly reproducible enzyme-linked immunosorbent assay detecting anti-gliadin antibodies in serum to screen for coeliac disease (CD) is described. By combining the results of anti-gliadin IgA and IgG determinations the overall sensitivity of the assay was found to be 100% and the specificity 96% for children and 99% for adults. Significantly elevated antigliadin IgA and IgG antibodies were detected in all 20 children and all 25 adults with untreated CD. False positive results were found in 1/79 histologically normal control and 5/86 disease control children, while for adults false positive rates were 0/74 and 1/34 for the healthy and disease control groups, respectively. Anti-gliadin IgA and IgG was measured in serum samples from 52 coeliac patients (11 children and 41 adults) treated with a gluten-free diet (GFD). Each of the children and 28 of the adults who followed a strict GFD had significantly lower IgA and IgG levels than untreated CD patients. The serum anti-gliadin IgA and IgG levels of the 13 adults not complying with a GFD were similar to those found for untreated CD patients. This assay is recommended as a screening test for CD as well as a tool for follow-up of treated patients.

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A reliable screening test for coeliac disease: enzyme‐linked immunosorbent assay to detect anti‐gliadin antibodies in serum

Gonczi

Skerritt

Mitchell

1991

Australian and New Zealand Journal of Medicine

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High Incidence of Atypical Forms of Coeliac Disease in a Pediatric Case Study

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A reliable screening test for coeliac disease: enzyme‐linked immunosorbent assay to detect anti‐gliadin antibodies in serum

A reliable screening test for coeliac disease: enzyme‐linked immunosorbent assay to detect anti‐gliadin antibodies in serum

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