High in vivo expression of interleukin‐17 receptor in synovial endothelial cells and chondrocytes from arthritis patients

Honorati, Maria Cristina; Melicòni, Riccardo; Pulsatelli, Lia; Canè, Stefania; Frizziero, L; Facchini, Andrea

doi:10.1093/rheumatology/40.5.522

Cited by 98 publications

(75 citation statements)

References 31 publications

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“…IL-17F was reported to employ IL-17R for signaling and IL-17F and IL-17A could induce IL-17R ubiquitination and DN-TRAF6, a dominant-negative mutant, could block IL-17F but not IL-17A triggered ubiquitination of IL-17R [46]. The IL-17R is ubiquitously expressed in virtually all cells and tissue and its expression was shown on synoviocytes, chondrocytes and synovial endothelial cells [47][48][49]. Expression of different IL-17 homologs (IL-17A, C, E and F) was detected in synovial fluid mononuclear cells from RA patients and different IL-17R (IL-17RA, IL-17RB, C and D) expression was noted in fibroblast-like synoviocytes of RA patients [50].…”

Section: What Is the Most Physiologically Relevant Target Of Il-17a Imentioning

confidence: 99%

IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?

Lubberts¹

2008

Cytokine

269

230

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Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel cytokine family in the pathogenesis of chronic destructive joint inflammation. Whether the successful anti-IL-17A cytokine therapy in murine arthritis can be effectively translated to human arthritis need to be tested in clinical trials in humans. Interestingly, IL-17A and IL-17F are secreted by the novel T helper subset named Th17. This novel pathogenic T cell population induces autoimmune inflammation in mice and is far more efficient at inducing Th1-mediated autoimmune inflammation in mice than classical Th1 cells (IFN-c). In addition to IL-17A and IL-17F, Th17 cells are characterized by expression of IL-6, TNF, GM-CSF, IL-21, IL-22 and IL-26. Th17 cells have been established as a separate lineage of T helper cells in mice distinct from conventional Th1 and Th2 cells. Whether this also applies to human Th17 and whether RA is a Th1 or a Th17 mediated disease is still not clear. This review summarizes the findings about the role of IL-17 in arthritis and discusses the impact of the discovery of the novel Th17 cells for arthritis. Further studies are needed to unravel the role of Th17 cells and the interplay of IL-17 and other Th17 cytokines in the pathogenesis of arthritis and whether regulating Th17 cell activity will have additional value compared to neutralizing IL-17A activity alone. This might help to reach the ultimate goal not only to treat RA patients but to prevent the development of this crippling disease.

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Section: What Is the Most Physiologically Relevant Target Of Il-17a Imentioning

confidence: 99%

IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?

Lubberts¹

2008

Cytokine

269

230

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“…Although IL-17 plays a protective role in host defense against extracellular pathogens, excessive activation of this pathway contributes to autoimmunity process [25]. Th17 cells and IL-17 levels are elevated in both human and mouse models of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis [25,[27][28][29][30]. However, the exact role of Th17 cells in the development of type 1 diabetes remains controversial [31,32].…”

Section: Type 1 Diabetes and Th17 Cell Subsetmentioning

confidence: 99%

Th17 cell-Mediated Responses in Type 1 Diabetes Pathogenesis

J.N.U¹

2013

J Clin Cell Immunol

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Type 1 diabetes (T1D) is an autoimmune disease characterized by a selective destruction of insulin-producing pancreatic beta cells. In general, Th1 cytokines are involved in the development of autoimmune diseases, whereas Th2 and regulatory cytokines result in disease prevention. More recently, a new population of IL-17-producing CD4+ T cells has been proposed to represent a distinct T helper cell lineage, named Th17 cells. Th17 cells are critically involved in the development of many autoimmune diseases; however, the exact role of this T cell subset in T1D pathogenesis remains controversial. Here, we review the conflicting evidences about a possible participation of Th17 cells in T1D development and progression, both in diabetic patients and experimental diabetes models.

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“…The products of TH17 cells, such as IL-17 and IL-23, are present in the serum, synovial fluid and synovial tissue of the majority of patients with RA, while they are absent in osteoarthritis (39)(40)(41). Under normal conditions, IL-17 is undetectable or detected at very low levels in the serum of healthy controls.…”

Section: Th17 Cells In Human Autoimmune Diseasesmentioning

confidence: 99%

Autoimmune diseases in the TH17 era

Mesquita

Cruvinel

Câmara

et al. 2009

Braz J Med Biol Res

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A new subtype of CD4 + T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases, the fine balance between the proportion and degree of activation of the various T lymphocyte subsets can contribute to persistent undesirable inflammatory responses and tissue replacement by fibrosis. This review highlights the importance of TH17 cells in this process by providing an update on the biology of these cells and focusing on their biology and differentiation processes in the context of immune-mediated chronic inflammatory diseases.

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High in vivo expression of interleukin‐17 receptor in synovial endothelial cells and chondrocytes from arthritis patients

Cited by 98 publications

References 31 publications

IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?

IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?

Th17 cell-Mediated Responses in Type 1 Diabetes Pathogenesis

Autoimmune diseases in the TH17 era

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