High iliac calcium score is associated with increased severity and complexity of peripheral arterial disease and predicts global atherosclerotic burden

Abstract

Increased values of ICS, a new CTA marker of vascular calcification, are associated with a higher severity and complexity of PAD and a more depressed left ventricular function. High ICS values are also associated with increased i-IMT. Both can represent new surrogate markers of an increased atherosclerotic burden.

Calcium Score Predicts Mortality After Revascularization in Critical Limb Ischemia

“…Also, the CS is probably collinear to most of the comorbidities evaluated, as they are associated with atherosclerosis and that involves vascular calcifications. 5,17,18 By increasing the casuistic in a prospective study carried out by more institutions, more significant observations can be achieved.…”

“…Also, the CS is probably collinear to most of the comorbidities evaluated, as they are associated with atherosclerosis and that involves vascular calcifications. 5,17,18…”

“…3 Few published studies have assessed CLLA and its relation with cardiovascular morbidity and mortality in patients with PAD. [4][5][6] Calcification in the lower limb arteries was recognized as an independent risk factor for amputation and clinical worsening of PAD. 6 However, only 1 study evaluated the relationship between CLLA and surgical outcomes.…”

Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease (2020 edition)

“…Dual-energy CTA can improve the sensitivity and specificity of PAD diagnosis in diabetic patients, reaching 100% and 93.1% after multilevel reconstruction and 99% and 91.8% after maximum intensity projection, respectively [ 29 ]. A single-center, nonrandom observational prospective study showed that CTA can effectively determine lower limb ischemia and suggest left heart dysfunction ( r = −0.54; p <0.0001) [ 30 ]. A retrospective study also concluded that CTA is similar to DSA in treatment guidance, such as intravascular and open surgery rates (intravascular and open surgery rates p = 0.305) and reintervention rates (21% CTA and 16% DSA; p = 0.517).…”

Intermittent Administration of Nitroglycerin Sublingual Powder Compared with Placebo in Outpatients with Peripheral Artery Disease: Results of a Randomised Proof of Concept Study

“…The possibility that patients with a high atherosclerotic burden (coronary artery disease, carotid artery stenosis) 13,14 may have an increased benefit from GTN treatment was also explored. Indeed, these patients demonstrated a more pronounced increase of ICD and ACD in the GTN group compared with the placebo group at end of treatment visit (visit 7, W12; ICD: 65.0% vs. 9.2%; difference: þ55.8%).…”