High IL-13 production by human neonatal T cells: neonate immune system regulator?

Ribeiro-do-Couto, Laura M.; Boeije, L. C. M.; Kroon, Jojanneke S.; Hooibrink, Berend; Breur-Vriesendorp, Birgitta S.; Aarden, Lucien A.; Boog, Claire J. P.

doi:10.1002/1521-4141(200111)31:11<3394::aid-immu3394>3.0.co;2-b

Cited by 60 publications

(27 citation statements)

References 46 publications

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“…IL-13 stimulates human B cells to synthesize IgE (7), a key effector in Th2-mediated disease, while suppressing the expression of CD14 (8), a molecule involved in protection from atopy (9). IL13 is expressed in the placenta (10) and is actively secreted by T cells in the neonatal period (11), a time critical for susceptibility to allergic disease.…”

Section: Th2 Cell-selective Enhancement Of Human Il13 Transcription Bmentioning

confidence: 99%

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation

Cameron

Webster

Strempel

et al. 2006

The Journal of Immunology

110

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IL-13 is a central mediator of allergic inflammation. The single nucleotide polymorphism IL13-1112C>T (rs1800925) is associated with allergic phenotypes in ethnically distinct populations, but the underlying mechanism(s) remain unknown. Using in vivo, in vitro, and in silico analysis, we show that the IL13-1112T allele enhanced IL13 promoter activity in primary human and murine CD4+ Th2 lymphocytes. Increased expression of IL13-1112T in Th2 cells was associated with the creation of a Yin-Yang 1 binding site that overlapped a STAT motif involved in negative regulation of IL13 expression and attenuated STAT6-mediated transcriptional repression. Because IL-13 secretion was increased in IL13-1112TT homozygotes, we propose that increased expression of IL13-1112T in vivo may underlie its association with susceptibility to allergic inflammation. Interestingly, IL13-1112T had opposite transcriptional effects in nonpolarized CD4+ T cells, paralleled by distinct patterns of DNA-protein interactions at the IL13 promoter. Our findings suggest the nuclear milieu dictates the functional outcome of genetic variation.

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Section: Th2 Cell-selective Enhancement Of Human Il13 Transcription Bmentioning

confidence: 99%

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation

Cameron

Webster

Strempel

et al. 2006

The Journal of Immunology

110

View full text Add to dashboard Cite

show abstract

“…The IgG subclass pattern observed after early life immunization of mice is, nevertheless, characterized by a relatively high IgG1/IgG2a ratio [29,30]. This pattern reflects the Th2-biased conditions of the immune system in the newborn, shown by low production of IFN-c, but relatively high production of IL-4, IL-5 and IL-13 after immunization with TD antigens under neutral conditions [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Early life T cell responses to pneumococcal conjugates increase with age and determine the polysaccharide‐specific antibody response and protective efficacy

et al. 2006

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Immunization with a tetanus-protein (TT) pneumococcal polysaccharide (PPS) conjugate vaccine (Pnc1-TT) induces protective immunity against lethal pneumococcal infections in neonatal and infant mice, but anti-PPS IgG response and protective efficacy is lower than in adult mice. Here, we show that reduced antibody (Ab) response and protection against infections is directly related to impaired T cell response to the carrier. Whereas spleen cells from adult mice immunized with Pnc1-TT responded with proliferation and IFN-gamma secretion to in vitro stimulation with TT, spleen cells from neonatal and infant mice did not. However, significant, but age dependent, Th2-cytokine responses were observed in mice immunized with Pnc1-TT. Impaired IFN-gamma production upon TT-stimulation in vitro was also reflected in reduced IFN-gamma/IL-5 ratio. The IL--5 response correlated with IgG anti-PPS titers, and the lack of PPS Ab in the majority of neonatal mice was clearly associated with absence of carrier-specific IL-5 production. These results show that immunization with Pnc1-TT induces carrier-specific T cell responses that increase with age and determine the levels of PPS-specific Ab elicited. Whereas a weak and Th2-biased response was observed in neonatal mice, infant mice showed a mixed Th1-Th2 response as observed in adults

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“…Ex utero, the diminished IFN-g /IL-12 production by neonatal cells may result from the abundance of Th2 cytokines that suppress synthesis of IFN-g. This possibility is supported by the observation that cord blood T cells produce significantly higher amount of IL-13 than T cells from adults [23].…”

mentioning

confidence: 99%

Down-regulation of Th1 responses in human neonates

Maródi

2002

Clinical and Experimental Immunology

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High IL-13 production by human neonatal T cells: neonate immune system regulator?

Cited by 60 publications

References 46 publications

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation

Early life T cell responses to pneumococcal conjugates increase with age and determine the polysaccharide‐specific antibody response and protective efficacy

Down-regulation of Th1 responses in human neonates

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High IL-13 production by human neonatal T cells: neonate immune system regulator?

Cited by 60 publications

References 46 publications

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C&gt;T, a Polymorphism Associated with Allergic Inflammation

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C&gt;T, a Polymorphism Associated with Allergic Inflammation

Early life T cell responses to pneumococcal conjugates increase with age and determine the polysaccharide‐specific antibody response and protective efficacy

Down-regulation of Th1 responses in human neonates

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Product

Resources

About

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation