High hydrostatic pressure encapsulation of doxorubicin in ferritin nanocages with enhanced efficiency

Qi, Wang; Zhang, Chun; Liu, Liping; Li, Zenglan; Guo, Fangxia; Li, Xiunan; Luo, Jian; De, Zhao; Liu, Yongdong; Su, Zhiguo

doi:10.1016/j.jbiotec.2017.05.025

Cited by 30 publications

(28 citation statements)

References 41 publications

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“…High hydrostatic pressure (HHP) has drawn considerable attention because it could reversibly change protein conformation in the scope of 200-300 MPa by impairing hydrophobic interactions and increasing protein solubility [77]. Previous studies by our research group have shown that HHP treatment had little effect on the primary and secondary structure of soybean seed ferritin (SSF), but greatly changed its tertiary and quaternary structure [78].…”

Section: Expansion Of Ferritin Channels By Different Methods For Encamentioning

confidence: 99%

“…Previous studies by our research group have shown that HHP treatment had little effect on the primary and secondary structure of soybean seed ferritin (SSF), but greatly changed its tertiary and quaternary structure [78]. Recently, HHP has been used to encapsulate DOX into HuHF instead of using pH or urea to disassemble the protein cage [77]. After varying experimental conditions such as pH, pressure, concentration, additives, and post-treatment protocols, the optimal treatment conditions were obtained with the greatest encapsulation efficiency [79].…”

Section: Expansion Of Ferritin Channels By Different Methods For Encamentioning

confidence: 99%

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Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine

Zhang

Zhao

2020

Nanomaterials

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Compared with other nanocarriers such as liposomes, mesoporous silica, and cyclodextrin, ferritin as a typical protein nanocage has received considerable attention in the field of food, nutrition, and medicine owing to its inherent cavity size, excellent water solubility, and biocompatibility. Additionally, ferritin nanocage also serves as a versatile bio-template for the synthesis of a variety of nanoparticles. Recently, scientists have explored the ferritin nanocage structure for encapsulation and delivery of guest molecules such as nutrients, bioactive molecules, anticancer drugs, and mineral metal ions by taking advantage of its unique reversible disassembly and reassembly property and biomineralization. In this review, we mainly focus on the preparation and structure of ferritin-based nanocarriers, and regulation of their self-assembly. Moreover, the recent advances of their applications in food nutrient delivery and medical diagnostics are highlighted. Finally, the main challenges and future development in ferritin-directed nanoparticles’ synthesis and multifunctional applications are discussed.

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Section: Expansion Of Ferritin Channels By Different Methods For Encamentioning

confidence: 99%

Section: Expansion Of Ferritin Channels By Different Methods For Encamentioning

confidence: 99%

Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine

Zhang

Zhao

2020

Nanomaterials

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“…Its loading capacity depends on several factors, including MW of the drug, the encapsulation strategy, and choice of co-solvent for entrapping drugs. Metal salts achieve the highest encapsulation efficiency with nearly 5000 particles of AgNO 3 fitting in a single cage, whereas small, hydrophobic molecules – including many chemotherapeutics, exhibit lower loading efficiency [ 510 , 511 ].…”

Section: Applications In Drug Deliverymentioning

confidence: 99%

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

Varanko

Saha

Chilkoti

2020

Advanced Drug Delivery Reviews

186

110

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Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials —naturally derived, chemically synthesized and recombinant— with a focus on the molecular features that modulate their structure-function relationships for drug delivery.

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“…Through this method a DOX final load of 121 molecules per PNPs was achieved which remained stable in neutral pH for over 25 h [30]. In another drug-loading method, Wang et al [86] tested high hydrostatic pressure (500 MPa) at a pH of 5.5 to disassemble ferritin and to increase protein conformation recovery. Following disassembly at high pressure, a gradual decompression was used to induce gently ferritin reassembly and DOX encapsulation.…”

Section: The Application Of Pnps As Ndds For Cancer Therapeutics Amentioning

confidence: 99%

Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

et al. 2019

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In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.

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High hydrostatic pressure encapsulation of doxorubicin in ferritin nanocages with enhanced efficiency

Cited by 30 publications

References 41 publications

Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine

Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

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