High Heritability of Telomere Length In Families With Bipolar Disorder

Martínez, Daniela; Millischer, Vincent; Michelon, Leandro; Camilo, Caroline; Brentani, Helena; Esteban, Nubia; Krieger, José Eduardo; Pereira, A. S.; Lavebratt, Catharina; Schalling, Martin; Vallada, Homero

doi:10.1016/j.euroneuro.2016.09.421

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“…Previous studies have suggested that the unaffected relatives of patients with BD have an increased risk of experiencing affective disturbances than relatives of healthy controls [2,3,4]. Although genetic factors strongly influence the development of BD [5,6,7], most relatives of patients with BD (approximately 60%) who have similar genotypes will not manifest the disorder [8]. An alternative method of examining disease expression of BD is comparing the phenotypes unique to BD patients with those of unaffected relatives and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network

Teng

et al. 2019

Brain Sciences

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Bipolar disorder (BD) is a genetically and phenotypically complex psychiatric disease. Although previous studies have suggested that the relatives of BD patients have an increased risk of experiencing affective disturbances, most relatives who have similar genotypes may not manifest the disorder. We aim to identify the neuroimaging alterations—specifically, the cortical folding structures of the anterior limbic network (ALN)—in BD patients and their siblings, compared to healthy controls. The shared alterations in patients and their siblings may indicate the hereditary predisposition of BD, and the altered cortical structures unique to BD patients may be a probe of BD expression. High-resolution, T1-weighted magnetic resonance images for 17 euthymic patients with BD, 17 unaffected siblings of BD patients, and 22 healthy controls were acquired. We categorized the cortical regions within the ALN into sulcal and gyral areas, based on the shape index, followed by the measurement of the folding degree, using the curvedness. Our results revealed that the changes in cortical folding in the orbitofrontal and temporal regions were associated with a hereditary predisposition to BD. Cortical folding structures in multiple regions of the ALN, particularly in the striatal–thalamic circuit and anterior cingulate cortex, could be used to differentiate BD patients from healthy controls and unaffected siblings. We concluded that the cortical folding structures of ALN can provide potential biomarkers for clinical diagnosis of BD and differentiation from the unaffected siblings.

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Section: Introductionmentioning

confidence: 99%

Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network

Teng

et al. 2019

Brain Sciences

View full text Add to dashboard Cite

show abstract

High Heritability of Telomere Length In Families With Bipolar Disorder

Cited by 1 publication

References 0 publications

Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network

Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network

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