High hepatitis C virus (HCV) prevalence among men who have sex with men (MSM) in Vietnam and associated risk factors: 2010 Vietnam Integrated Behavioural and Biologic Cross-Sectional Survey

Nadol, Patrick; O’Connor, Siobhán; Duong, Hao T.; Mixson‐Hayden, Tonya; Tram, Tran Hong; Xia, Guoliang; Kaldor, John; Law, Matthew; Nguyen, Tuan Anh

doi:10.1136/sextrans-2015-052518

Cited by 14 publications

(13 citation statements)

References 20 publications

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“…Vietnam is among the 20 countries with the highest burden of chronic HCV infection in the world and PWID are the most affected population. HCV antibody prevalence among the general population in Vietnam ranged from 0.2-3.3% [4], but it is substantially higher among PWID (74-87%) [5], HIV-infected individuals (22.9-89.0%) [6], HIV-infected MSM (83.1-100%) and HIV-uninfected MSM (8.9-28.2%) [7], and multi-transfused and dialysis patients (6-26.6%) [8,9]. A modelling exercise conducted by the Vietnam Ministry of Health and World Health Organization (WHO) in 2017 estimated that there were nearly one million people with chronic HCV infection in Vietnam.…”

Section: Introductionmentioning

confidence: 99%

Acceptability and Usability of HCV Self-Testing in High Risk Populations in Vietnam

Nguyen

Nguyen²,

et al. 2021

Diagnostics

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HIV self-testing has emerged as a safe and effective approach to increase the access to and uptake of HIV testing and treatment, especially for key populations. Applying self-testing to hepatitis C virus (HCV) may also offer an additional way to address low coverage of HCV testing and to accelerate elimination efforts. To understand the potential for HCV self-testing (HCVST), an observational study was conducted to assess the acceptability and usability of the OraQuick® HCV Self-Test (prototype) among people who inject drugs (PWID) and men who have sex with men (MSM) in Thai Nguyen, a province in northern Vietnam. A total of 105 PWID and 104 MSM were eligible and agreed to participate in the study. Acceptability, defined as the proportion of participants among eligible subjects who agreed to participate in the study, was 92.9% in PWID and 98.6% in MSM. Compared to MSM, PWID were older (median age: 45 vs. 22 years; p < 0.0001) and had a lower education level (high school and college: 38.1% vs. 100%; p < 0.0001). HCVST usability was high among MSM with fewer observed mistakes, difficulties, or participants requiring assistance (33.7%, 28.8%, and 17.3%, respectively) compared to PWID (62.9%, 53.3%, and 66.7%, respectively; all p < 0.0001)). Inter-reader and inter-operator agreement were good in both groups (Kappa coefficient range: 0.61–0.99). However, the concordance between HCVST and study staff -read or performed HCV testing was lower among PWID than MSM (inter-reader concordance 88.6% vs. 99.0% and inter-operator concordance 81.9% vs. 99%). Overall, HCVST was highly acceptable with moderate to high usability among PWID and MSM in Thai Nguyen. Efforts to provide support and assistance may be needed to optimize performance, particularly for PWID populations and for those who are older and with lower literacy or education levels.

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Section: Introductionmentioning

confidence: 99%

Acceptability and Usability of HCV Self-Testing in High Risk Populations in Vietnam

Nguyen

Nguyen²,

et al. 2021

Diagnostics

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“…Recent studies in different cities in China have not shown increased or increasing HCV incidences among MSM . Needle‐sharing among injection drug users (IDUs) rather than male‐to‐male sex remains the most common cause of HCV spread in China and Vietnam . Nevertheless, HCV incidences among HIV–positive non‐IDU patients have reportedly increased in studies in Hong Kong (from 0.13 before 2002 to 0.47 per 100 person‐years in 2008‐2013), Taiwan (from 0 in 1994‐2000 to 1.01 per 100 person‐years in 2006‐2010), and Japan (from 0 in 2005‐2006 to 2.49 per 100 person‐years in 2011‐2012) .…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of acute HCV infection in HIV–positive patients from Hong Kong, Taipei, Tokyo

Sun

Uemura

Wong

et al. 2019

Liver International

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Background: Acute hepatitis C virus (HCV) infections have been increasingly reported among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the Asia-Pacific region. It remains unknown whether international network of HCV transmission has occurred in this region. Methods: HIV-positive patients with acute HCV infection, defined as HCV seroconversion within a year or documented acute hepatitis with seroconversion, diagnosed in Hong Kong, Taipei and Tokyo during 2010-2016 were included in this molecular epidemiology study. The NS5B region of the HCV genome (365 bp) was amplified using nested polymerase chain reaction and sequenced. Results: Of 234 HIV-positive patients with acute HCV infection, all were male with 94% being MSM. At the diagnosis of acute HCV infection, 73.5% had concurrent sexually transmitted diseases and 88.0% were receiving combination antiretroviral therapy. The most prevalent HCV genotype was 3a, 2a and 1b in Hong Kong, Taipei and Tokyo respectively. Nine independent clusters belonging to five genotypes (1b, 2a, 2c, 3a and 6a) were identified, each of which occurred in one city without overlapping except for one 3a sequence from Taipei that was closely related genetically to the Hong Kong cluster. Conclusions: No international network of HCV transmission was identified among HIV-positive patients in the three Asia-Pacific cities. The transmission dynamics of

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“…The WHO recommends all persons at increased risk of infection receive HBV surface antigen and HCV antibody testing [3]. This recommendation includes men who have sex with men (MSM), a group with higher prevalence of HBV and HCV compared to the general population in both high-income countries and LMICs [4], [5], [6], [7], [8].…”

Section: Introductionmentioning

confidence: 99%

A crowdsourced intervention to promote hepatitis B and C testing among men who have sex with men in China: A nationwide online randomized controlled trial

et al. 2019

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BackgroundCrowdsourcing may be an effective strategy to develop test promotion materials. We conducted an online randomized controlled trial (RCT) to evaluate a crowdsourced intervention to promote hepatitis B virus (HBV) and hepatitis C virus (HCV) testing among men who have sex with men (MSM) in China.MethodsMSM never previously tested for hepatitis were recruited through social media. Eligible men were randomized to receive an online crowdsourced intervention or no testing promotion materials. Outcomes including self-reported and confirmed HBV and HCV test uptake were assessed after four weeks. Odds ratios (OR) with 95% confidence intervals (95% CI) of men achieving primary and secondary outcomes between the intervention and control arms were calculated.Findings556 eligible men were enrolled. Overall, 17•4% (97/556) of men self-reported HBV and HCV testing and 7•9% (44/556) confirmed HBV and HCV test uptake. The intervention was seen by 72•1% and 29•0% of men in the intervention and control arms, respectively. In intention-to-treat analysis, confirmed HBV and HCV test uptake was similar between the two arms, both when using a missing=failure approach (OR 0•98, 95% CI 0•53–1•82) or multiple imputation (OR 1•46, 95% CI 0•72–2•95).InterpretationThis RCT extends the literature by developing and evaluating an intervention to spur hepatitis testing in a middle-income country with a high burden of hepatitis. Overall test uptake among MSM in China was similar to previous interventions promoting hepatitis testing in high-income countries. We found frequent intervention sharing, complicating interpretation of the results, and the role of crowdsourcing to promote hepatitis testing remains unclear.

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High hepatitis C virus (HCV) prevalence among men who have sex with men (MSM) in Vietnam and associated risk factors: 2010 Vietnam Integrated Behavioural and Biologic Cross-Sectional Survey

Cited by 14 publications

References 20 publications

Acceptability and Usability of HCV Self-Testing in High Risk Populations in Vietnam

Acceptability and Usability of HCV Self-Testing in High Risk Populations in Vietnam

Molecular epidemiology of acute HCV infection in HIV–positive patients from Hong Kong, Taipei, Tokyo

A crowdsourced intervention to promote hepatitis B and C testing among men who have sex with men in China: A nationwide online randomized controlled trial

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