High harmonic exploring on different materials in dynamic atomic force microscopy

Zheng, Zhiyue; Xu, Rui; Ye, Shili; Hussain, Sabir; Ji, Wei; Cheng, Peng; Li, Yanjun; Sugawara, Yasuhiro; Cheng, Zhihai

doi:10.1007/s11431-017-9161-4

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…AM-FM offers nanomechanical information of the specimen such as Young's modulus and contact stiffness [38] and has several advantages including fast scanning, high spatial resolution, and low forces applied to the sample. Although these modes are quite new, they have been used for investigating several biological samples, including proteins; small biological fibrils, like amyloid fibrils; lipid membranes; and viruses [39–42]. Also, it has been demonstrated that malign and benign cell lines present significant differences in their viscoelastic response [43].…”

Section: Atomic Force Microscopy: Imaging Modesmentioning

confidence: 99%

Atomic Force Microscopy on Biological Materials Related to Pathological Conditions

et al. 2019

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Atomic force microscopy (AFM) is an easy-to-use, powerful, high-resolution microscope that allows the user to image any surface and under any aqueous condition. AFM has been used in the investigation of the structural and mechanical properties of a wide range of biological matters including biomolecules, biomaterials, cells, and tissues. It provides the capacity to acquire high-resolution images of biosamples at the nanoscale and allows at readily carrying out mechanical characterization. The capacity of AFM to image and interact with surfaces, under physiologically relevant conditions, is of great importance for realistic and accurate medical and pharmaceutical applications. The aim of this paper is to review recent trends of the use of AFM on biological materials related to health and sickness. First, we present AFM components and its different imaging modes and we continue with combined imaging and coupled AFM systems. Then, we discuss the use of AFM to nanocharacterize collagen, the major fibrous protein of the human body, which has been correlated with many pathological conditions. In the next section, AFM nanolevel surface characterization as a tool to detect possible pathological conditions such as osteoarthritis and cancer is presented. Finally, we demonstrate the use of AFM for studying other pathological conditions, such as Alzheimer’s disease and human immunodeficiency virus (HIV), through the investigation of amyloid fibrils and viruses, respectively. Consequently, AFM stands out as the ideal research instrument for exploring the detection of pathological conditions even at very early stages, making it very attractive in the area of bio- and nanomedicine.

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Section: Atomic Force Microscopy: Imaging Modesmentioning

confidence: 99%

Atomic Force Microscopy on Biological Materials Related to Pathological Conditions

et al. 2019

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“…An advanced AFM technique, namely, the contact resonance (CR) mode 41 (Figures 4d and S9), was used to directly characterize the out-of-plane modulus by recording the shift of the resonance frequency of the probe−sample system (see details in the Supporting Information). Based on the simple model explained in the Supporting Information, we can approximately estimate the ratio of the elastic modulus of KR and that of the ZR region to be ∼1.002.…”

Section: Resultsmentioning

confidence: 99%

Atomically Asymmetric Inversion Scales up to Mesoscopic Single-Crystal Monolayer Flakes

Pang

Pan

et al. 2020

ACS Nano

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Symmetry is highly relevant with various quantities and phenomena in physics. While the translational symmetry breaks at the edges of two-dimensional hexagonal crystalline flakes, it is usually associated with the breaking of central inversion symmetry that is yet to be observed in terms of physical properties. Here, we report an experiment–theory joint study on in-plane compressed single-crystal monolayer WS2 flakes. Although the flakes show a hexagonal appearance with a C6 symmetry, our density functional theory calculations predict that their in-plane strain, geometric structure, work-function, energy bandgap, and mechanical modulus are nonequivalent among the triangular regions with different edge terminations at the atomic scale, and the flakes exhibit self-patterns with a C3 symmetry. Such nonequivalence of physical properties and concomitant self-patterns persist even in a 50 μm-sized monolayer WS2, observed using atomic force microscopy. This indicates that the symmetry arising from the atomic geometry could preserve up to tens of microns for both geometric and properties of the flake, regardless of its mesoscopic geometry, i.e., C6 here. Such a detectable mesoscopic scale and symmetric nano- to mesoscale patterns provide promising building blocks for 2D materials and devices and also allow edge terminations of 2D flakes to be directly distinguished.

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“…The exhaustive list of AFM imaging modes is very long. Many of the recently developed modes are used for studying a number of biological samples, including proteins; small biological fibrils, like lipid membranes; amyloid fibrils; and viruses with the microcantilever as the sensing element [ 121 , 122 ]. Moreover, it has been demonstrated that malign and benign cell lines present significant differences in their viscoelastic response using MMM [ 123 ].…”

Section: Modes Of Operations Of Cantilever-based Afmmentioning

confidence: 99%

Review: Cantilever-Based Sensors for High Speed Atomic Force Microscopy

Alunda¹,

Lee

2020

Sensors

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This review critically summarizes the recent advances of the microcantilever-based force sensors for atomic force microscope (AFM) applications. They are one the most common mechanical spring–mass systems and are extremely sensitive to changes in the resonant frequency, thus finding numerous applications especially for molecular sensing. Specifically, we comment on the latest progress in research on the deflection detection systems, fabrication, coating and functionalization of the microcantilevers and their application as bio- and chemical sensors. A trend on the recent breakthroughs on the study of biological samples using high-speed atomic force microscope is also reported in this review.

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High harmonic exploring on different materials in dynamic atomic force microscopy

Cited by 10 publications

References 25 publications

Atomic Force Microscopy on Biological Materials Related to Pathological Conditions

Atomic Force Microscopy on Biological Materials Related to Pathological Conditions

Atomically Asymmetric Inversion Scales up to Mesoscopic Single-Crystal Monolayer Flakes

Review: Cantilever-Based Sensors for High Speed Atomic Force Microscopy

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