High-grade vaginal intraepithelial neoplasia and recurrence risk: analysis of an Italian regional referral center series

Monti, Ermelinda; Libutti, Giada; Loreto, Eugenia Di; Boero, Veronica; Barbara, Giussy; Cetera, Giulia Emily; Cipriani, Sonia; Parazzini, Fabio

doi:10.1007/s00404-022-06886-6

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…The literature reports a range of HPV infection rates in VAIN, varying from 85-98%. Among the different types of HPV infections in VAIN, HPV16 is the most common [14][15] . However, there are variations in the results, which could be attributed to differences in sample size or testing methods among different ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical characteristics and risk factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia

he,

Jiang

2023

Preprint

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Objective: This study aims to explore the clinical characteristics and risk factors of cervical intraepithelial neoplasia (CIN) complicated with vaginal intraepithelial neoplasia (VaIN) Methods: A total of 229 patients diagnosed with CIN complicated with VAIN, who received treatment at the Gynecology Department of the Third Xiangya Hospital of Central South University between January 2013 and January 2023, were included in this study. Additionally, 458 CIN patients treated during the same period were randomly selected as a control group. The clinical characteristics of both groups were compared and analyzed to identify risk factors for CIN complicated with VAIN. Results: The mean age of patients in the CIN complicated with VAIN group was 49.84±14.03 years, with 55.5% being postmenopausal. In the CIN group, the mean age was 45.79±11.41 years, with 31.4% being postmenopausal. The difference between the two groups was statistically significant (p < 0.05). Among the CIN complicated with VAIN group, 97.4% of patients had HPV infection, with 46.7% being infected with multiple HPVs and 20.1% being infected with three or more HPVs. The infection rate was significantly higher than that in the CIN group (91.0%, 29.5%, 10.5%). There was a significant positive correlation between the grade of CIN and VAIN (Kappa=0.274, p < 0.05), indicating that as the grade of cervical lesions increased, so did the degree of vaginal lesions. Multifactor analysis revealed that menopause (OR=2.522), multiple HPV infections (OR=1.491), and three or more categories of HPV infections (OR=1.529) were independent risk factors for CIN complicated with VAIN (p < 0.05). Conclusion: In order to provide early intervention and avoid missed diagnosis and treatment, it is important to pay attention to vaginal examination during colposcopy for postmenopausal and CIN patients with multiple HPV infections. This will help in timely detection of vaginal lesions.

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Section: Discussionmentioning

confidence: 99%

Analysis of clinical characteristics and risk factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia

he,

Jiang

2023

Preprint

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“…While most patients with VaIN II and III can be cured after treatment, a small number may experience relapse or progression to invasive cancer, necessitating long-term follow-up. A study by Monti et al found that the recurrence rate of vaginal HSIL after treatment was 17%, with a 5-year cumulative recurrence rate of 30.4% and a median recurrence time of 15.5 months [ 66 ]. VaIN after hysterectomy still has a high risk of recurrence and progression after initial treatment.…”

Section: Recurrence and Follow-upmentioning

confidence: 99%

Comprehensive evaluation of vaginal intraepithelial neoplasia development after hysterectomy: insights into diagnosis and treatment strategies

Wei,

2024

Arch Gynecol Obstet

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Vaginal intraepithelial neoplasia (VaIN), a precancerous lesion associated with human papillomavirus (HPV), impacts women’s health and quality of life. However, the natural progression of VaIN after hysterectomy remains uncertain, due to its low incidence. The existing literature predominantly consists of single-center retrospective studies lacking robust evidence-based medicine. The management of VaIN after hysterectomy is diverse and controversial, lacking a consensus on the optimal approach. Therefore, it is imperative to investigate the development of VaIN after hysterectomy, emphasizing the importance of accurate diagnosis and effective management strategies.

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High-grade vaginal intraepithelial neoplasia and recurrence risk: analysis of an Italian regional referral center series

Cited by 2 publications

References 27 publications

Analysis of clinical characteristics and risk factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia

Analysis of clinical characteristics and risk factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia

Comprehensive evaluation of vaginal intraepithelial neoplasia development after hysterectomy: insights into diagnosis and treatment strategies

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