High-grade prostatic intraepithelial neoplasia

Bostwick, David G.; Qian, Junqi

doi:10.1038/modpathol.3800053

Cited by 224 publications

(139 citation statements)

References 177 publications

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“…This indicates that the prostate cancer risk is increased with the increase in the number of specimens found to have HGPIN on the 1 st biopsy. Our result also agreed with that of Bostwick et al [2], Abdel-khalek et al [23] and Rosser et al [27], However, it disagreed with studies that revealed lower prostate detection rate (De Nunzio et al [22], Kamoi et al [28] and Epstein & Herawi [29]) and other studies with higher prostate detection rate (Keetch et al [30] and Borboroglu et al [25]). …”

Section: Discussionsupporting

confidence: 37%

Is High Grade Prostatic Intraepithelial Neoplasia a Risk Factor for Prostate Cancer?—A Local Study

Al-Dabbagh¹,

Mohammad²,

Jaffal³

2018

OJU

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Objective: To determine the consequence of recognizing high grade prostatic intraepithelial neoplasia (HGPIN) & its extent on initial sextant prostatic biopsy then identifying its associated risk of finding prostate cancer on subsequent biopsy. Patients and methods: Seventy-one men were subjected to transrectal ultrasound guided sextant prostate biopsy due to elevated serum prostate specific antigen (S.PSA) > 4 ng /ml, an abnormal digital rectal examination (DRE) and/or transrectal ultrasound (TRUS) findings. The number, percentage, as well as bilateral and multifocal involvement of specimens positive for HGPIN were recorded in every patient. The percentage of cancer detected in these patients on repeat biopsy within 1 year of the initial biopsy was also recorded. Results: The mean age and mean S.PSA level of our patients was 59.9 years and 7.9 ng/ml respectively. Of the 71 patients studied, initial biopsy revealed that (32.4%) had benign prostatic hyperplasia (BPH), (36.62%) had carcinoma, (25.35%) had HGPIN and (5.63%) had chronic prostatitis. On repeat biopsy within 1 year of initial biopsy cancer of the prostate was detected in 33.3% of our patients who were diagnosed with HGPIN on 1 st biopsy. All of them had multifocal involvement on the initial biopsy. Conclusion: Recognizing HGPIN on 1 st biopsy (particularly multifocal involvement) is associated with great risk of prostate cancer development on subsequent biopsy, thus comprehensive follow-up of these patients is necessary.

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Section: Discussionsupporting

confidence: 37%

Is High Grade Prostatic Intraepithelial Neoplasia a Risk Factor for Prostate Cancer?—A Local Study

Al-Dabbagh¹,

Mohammad²,

Jaffal³

2018

OJU

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“…The American Cancer Society National Prostate Cancer Detection Project identified prostatic intraepithelial neoplasia (PIN) and cancer in 17 (5.2%) and 58 (15.8%) men, respectively, from a series of 330 biopsies from men participating in an early detection project. 1 Other studies have found high-grade PIN in up to 16.5% of contemporary needle biopsy specimens in urology office practice. [2][3][4] The diagnosis of HGPIN is predictive of subsequent cancer detection in 2.3-100% of patients.…”

mentioning

confidence: 99%

Bicalutamide 50 mg monotherapy in patients with isolated high-grade PIN: findings in repeat biopsies at 6 months

et al. 2006

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“…For the genetic and molecular evidence, HGPIN and prostate cancer have both raised rates of cell proliferation and cell death [18,19] and raised rate of neovascularization [1] compared with those in normal prostate. They are also phenotypically and morphometrically similar [1] and they share common molecular and genetic alterations [20], although the basal cell layer is disrupted in HGPIN and absent in prostate cancer [21]. …”

Section: Discussionmentioning

confidence: 99%

Concomitant High-Grade Prostatic Intraepithelial Neoplasia Is Associated with Good Prognosis Factors and Oncologic Outcome after Radical Prostatectomy

Ingels

Ploussard²,

Allory³

et al. 2013

Urol Int

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Objectives: To assess correlations between concomitant high-grade prostatic intraepithelial neoplasia (HGPIN), pathological features and oncologic outcomes after radical prostatectomy (RP). Material and Methods: We prospectively collected a single-institution database of 2,351 patients who underwent RP between 1998 and 2011. Results: 1,272 (54.1%) patients had HGPIN on specimens. The mean follow-up was 28 months. Presence of HGPIN was significantly associated with a favorable preoperative risk status and with pathological factors of poor prognosis in RP specimens. Patients without HGPIN had a worse biochemical recurrence-free survival compared with those with HGPIN in RP specimen (log-rank test: p = 0.015). The 3-year RFS rate was 73.9% for the HGPIN group versus 67.2%. The absence of HGPIN was also significantly correlated with the use of androgen deprivation treatment during the follow-up (p < 0.001). In Cox multivariate analysis, taking into account the other prognostic pathological factors, HGPIN was not an independent predictive factor for PSA failure (p = 0.868). Conclusion: HGPIN is associated with factors of good prognosis but fails to show independent significance when classical pathological prognostic factors are taken into account.

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High-grade prostatic intraepithelial neoplasia

Cited by 224 publications

References 177 publications

Is High Grade Prostatic Intraepithelial Neoplasia a Risk Factor for Prostate Cancer?—A Local Study

Is High Grade Prostatic Intraepithelial Neoplasia a Risk Factor for Prostate Cancer?—A Local Study

Bicalutamide 50 mg monotherapy in patients with isolated high-grade PIN: findings in repeat biopsies at 6 months

Concomitant High-Grade Prostatic Intraepithelial Neoplasia Is Associated with Good Prognosis Factors and Oncologic Outcome after Radical Prostatectomy

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